Owa T - Search Results

1

Selective degradation of splicing factor CAPERα by anticancer sulfonamides.

Uehara T, Minoshima Y, Sagane K, Sugi NH, Mitsuhashi KO, Yamamoto N, Kamiyama H, Takahashi K, Kotake Y, Uesugi M, Yokoi A, Inoue A, Yoshida T, Mabuchi M, Tanaka A, Owa T. Uehara T, et al. Among authors: owa t. Nat Chem Biol. 2017 Jun;13(6):675-680. doi: 10.1038/nchembio.2363. Epub 2017 Apr 24. Nat Chem Biol. 2017. PMID: 28437394

2

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

Kotake Y, Sagane K, Owa T, Mimori-Kiyosue Y, Shimizu H, Uesugi M, Ishihama Y, Iwata M, Mizui Y. Kotake Y, et al. Among authors: owa t. Nat Chem Biol. 2007 Sep;3(9):570-5. doi: 10.1038/nchembio.2007.16. Epub 2007 Jul 22. Nat Chem Biol. 2007. PMID: 17643112

3

Profiling novel sulfonamide antitumor agents with cell-based phenotypic screens and array-based gene expression analysis.

Yokoi A, Kuromitsu J, Kawai T, Nagasu T, Sugi NH, Yoshimatsu K, Yoshino H, Owa T. Yokoi A, et al. Among authors: owa t. Mol Cancer Ther. 2002 Feb;1(4):275-86. Mol Cancer Ther. 2002. PMID: 12467223

4

Therapeutic potential and molecular mechanism of a novel sulfonamide anticancer drug, indisulam (E7070) in combination with CPT-11 for cancer treatment.

Ozawa Y, Kusano K, Owa T, Yokoi A, Asada M, Yoshimatsu K. Ozawa Y, et al. Among authors: owa t. Cancer Chemother Pharmacol. 2012 May;69(5):1353-62. doi: 10.1007/s00280-012-1844-8. Epub 2012 Feb 17. Cancer Chemother Pharmacol. 2012. PMID: 22349812

5

Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide.

Owa T, Yokoi A, Yamazaki K, Yoshimatsu K, Yamori T, Nagasu T. Owa T, et al. J Med Chem. 2002 Oct 24;45(22):4913-22. doi: 10.1021/jm0201060. J Med Chem. 2002. PMID: 12383017

6

E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling.

Yamada K, Hori Y, Inoue S, Yamamoto Y, Iso K, Kamiyama H, Yamaguchi A, Kimura T, Uesugi M, Ito J, Matsuki M, Nakamoto K, Harada H, Yoneda N, Takemura A, Kushida I, Wakayama N, Kubara K, Kato Y, Semba T, Yokoi A, Matsukura M, Odagami T, Iwata M, Tsuruoka A, Uenaka T, Matsui J, Matsushima T, Nomoto K, Kouji H, Owa T, Funahashi Y, Ozawa Y. Yamada K, et al. Among authors: owa t. Cancer Res. 2021 Feb 15;81(4):1052-1062. doi: 10.1158/0008-5472.CAN-20-0782. Epub 2021 Jan 6. Cancer Res. 2021. PMID: 33408116

7

Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle.

Owa T, Yoshino H, Okauchi T, Yoshimatsu K, Ozawa Y, Sugi NH, Nagasu T, Koyanagi N, Kitoh K. Owa T, et al. J Med Chem. 1999 Sep 23;42(19):3789-99. doi: 10.1021/jm9902638. J Med Chem. 1999. PMID: 10508428

8

Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium.

Funahashi Y, Sugi NH, Semba T, Yamamoto Y, Hamaoka S, Tsukahara-Tamai N, Ozawa Y, Tsuruoka A, Nara K, Takahashi K, Okabe T, Kamata J, Owa T, Ueda N, Haneda T, Yonaga M, Yoshimatsu K, Wakabayashi T. Funahashi Y, et al. Among authors: owa t. Cancer Res. 2002 Nov 1;62(21):6116-23. Cancer Res. 2002. PMID: 12414636

9

Final results of a phase 2, open-label study of indisulam, idarubicin, and cytarabine in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome.

Assi R, Kantarjian HM, Kadia TM, Pemmaraju N, Jabbour E, Jain N, Daver N, Estrov Z, Uehara T, Owa T, Cortes JE, Borthakur G. Assi R, et al. Among authors: owa t. Cancer. 2018 Jul 1;124(13):2758-2765. doi: 10.1002/cncr.31398. Epub 2018 Apr 16. Cancer. 2018. PMID: 29660836 Free PMC article. Clinical Trial.

10

E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo.

Ozawa Y, Sugi NH, Nagasu T, Owa T, Watanabe T, Koyanagi N, Yoshino H, Kitoh K, Yoshimatsu K. Ozawa Y, et al. Among authors: owa t. Eur J Cancer. 2001 Nov;37(17):2275-82. doi: 10.1016/s0959-8049(01)00275-1. Eur J Cancer. 2001. PMID: 11677118

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