Pál G - Search Results

1

Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.

Nagy ZA, Héja D, Bencze D, Kiss B, Boros E, Szakács D, Fodor K, Wilmanns M, Kocsis A, Dobó J, Gál P, Harmat V, Pál G. Nagy ZA, et al. Among authors: pal g. J Biol Chem. 2022 Jun;298(6):101985. doi: 10.1016/j.jbc.2022.101985. Epub 2022 Apr 25. J Biol Chem. 2022. PMID: 35483450 Free PMC article.

2

Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2.

Héja D, Harmat V, Fodor K, Wilmanns M, Dobó J, Kékesi KA, Závodszky P, Gál P, Pál G. Héja D, et al. Among authors: pal g. J Biol Chem. 2012 Jun 8;287(24):20290-300. doi: 10.1074/jbc.M112.354332. Epub 2012 Apr 16. J Biol Chem. 2012. PMID: 22511776 Free PMC article.

3

Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2.

Héja D, Kocsis A, Dobó J, Szilágyi K, Szász R, Závodszky P, Pál G, Gál P. Héja D, et al. Among authors: pal g. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10498-503. doi: 10.1073/pnas.1202588109. Epub 2012 Jun 12. Proc Natl Acad Sci U S A. 2012. PMID: 22691502 Free PMC article.

4

Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway.

Megyeri M, Harmat V, Major B, Végh Á, Balczer J, Héja D, Szilágyi K, Datz D, Pál G, Závodszky P, Gál P, Dobó J. Megyeri M, et al. Among authors: pal g. J Biol Chem. 2013 Mar 29;288(13):8922-34. doi: 10.1074/jbc.M112.446500. Epub 2013 Feb 5. J Biol Chem. 2013. PMID: 23386610 Free PMC article.

5

MASP-1 and MASP-2 Do Not Activate Pro-Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors.

Oroszlán G, Kortvely E, Szakács D, Kocsis A, Dammeier S, Zeck A, Ueffing M, Závodszky P, Pál G, Gál P, Dobó J. Oroszlán G, et al. Among authors: pal g. J Immunol. 2016 Jan 15;196(2):857-65. doi: 10.4049/jimmunol.1501717. Epub 2015 Dec 16. J Immunol. 2016. PMID: 26673137

6

MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked.

Dobó J, Szakács D, Oroszlán G, Kortvely E, Kiss B, Boros E, Szász R, Závodszky P, Gál P, Pál G. Dobó J, et al. Among authors: pal g. Sci Rep. 2016 Aug 18;6:31877. doi: 10.1038/srep31877. Sci Rep. 2016. PMID: 27535802 Free PMC article.

7

The emerging roles of mannose-binding lectin-associated serine proteases (MASPs) in the lectin pathway of complement and beyond.

Dobó J, Pál G, Cervenak L, Gál P. Dobó J, et al. Among authors: pal g. Immunol Rev. 2016 Nov;274(1):98-111. doi: 10.1111/imr.12460. Immunol Rev. 2016. PMID: 27782318 Review.

8

Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum.

Nagy ZA, Szakács D, Boros E, Héja D, Vígh E, Sándor N, Józsi M, Oroszlán G, Dobó J, Gál P, Pál G. Nagy ZA, et al. Among authors: pal g. PLoS Pathog. 2019 Dec 20;15(12):e1008232. doi: 10.1371/journal.ppat.1008232. eCollection 2019 Dec. PLoS Pathog. 2019. PMID: 31860690 Free PMC article.

9

Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides.

Dürvanger Z, Boros E, Nagy ZA, Hegedüs R, Megyeri M, Dobó J, Gál P, Schlosser G, Ángyán AF, Gáspári Z, Perczel A, Harmat V, Mező G, Menyhárd DK, Pál G. Dürvanger Z, et al. Among authors: pal g. ACS Chem Biol. 2022 Apr 15;17(4):969-986. doi: 10.1021/acschembio.2c00114. Epub 2022 Apr 4. ACS Chem Biol. 2022. PMID: 35378038 Free PMC article.

10

Cutting Edge: A New Player in the Alternative Complement Pathway, MASP-1 Is Essential for LPS-Induced, but Not for Zymosan-Induced, Alternative Pathway Activation.

Paréj K, Kocsis A, Enyingi C, Dani R, Oroszlán G, Beinrohr L, Dobó J, Závodszky P, Pál G, Gál P. Paréj K, et al. Among authors: pal g. J Immunol. 2018 Apr 1;200(7):2247-2252. doi: 10.4049/jimmunol.1701421. Epub 2018 Feb 23. J Immunol. 2018. PMID: 29475986

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