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Design, synthesis, and biological evaluation of novel matrix metalloproteinase inhibitors as potent antihemorrhagic agents: from hit identification to an optimized lead.
Orbe J, Sánchez-Arias JA, Rabal O, Rodríguez JA, Salicio A, Ugarte A, Belzunce M, Xu M, Wu W, Tan H, Ma H, Páramo JA, Oyarzabal J. Orbe J, et al. Among authors: paramo ja. J Med Chem. 2015 Mar 12;58(5):2465-88. doi: 10.1021/jm501940y. Epub 2015 Feb 25. J Med Chem. 2015. PMID: 25686153
Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage.
Orbe J, Rodríguez JA, Sánchez-Arias JA, Salicio A, Belzunce M, Ugarte A, Chang HC, Rabal O, Oyarzabal J, Páramo JA. Orbe J, et al. Among authors: paramo ja. J Med Chem. 2015 Apr 9;58(7):2941-57. doi: 10.1021/jm501939z. Epub 2015 Feb 25. J Med Chem. 2015. PMID: 25686022
Phenotypic Screening To Discover Novel Chemical Series as Efficient Antihemorrhagic Agents.
de Miguel I, Orbe J, Sánchez-Arias JA, Rodríguez JA, Salicio A, Rabal O, Belzunce M, Sáez E, Xu M, Wu W, Tan H, Ma H, Páramo JA, Oyarzabal J. de Miguel I, et al. Among authors: paramo ja. ACS Med Chem Lett. 2018 Apr 16;9(5):428-433. doi: 10.1021/acsmedchemlett.7b00549. eCollection 2018 May 10. ACS Med Chem Lett. 2018. PMID: 29795754 Free PMC article.
CM-352 Efficacy in a Mouse Model of Anticoagulant-Associated Intracranial Hemorrhage.
Navarro-Oviedo M, Marta-Enguita J, Roncal C, Rodríguez JA, Zandio B, Lecumberri R, Hermida J, Oyarzabal J, Pineda-Lucena A, Páramo JA, Muñoz R, Orbe J. Navarro-Oviedo M, et al. Among authors: paramo ja. Thromb Haemost. 2022 Aug;122(8):1314-1325. doi: 10.1055/a-1759-9962. Epub 2022 Feb 3. Thromb Haemost. 2022. PMID: 35114692 Free PMC article.
Matrix metalloproteinase-10 effectively reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitor-mediated mechanism.
Orbe J, Barrenetxe J, Rodriguez JA, Vivien D, Orset C, Parks WC, Birkland TP, Serrano R, Purroy A, Martinez de Lizarrondo S, Angles-Cano E, Páramo JA. Orbe J, et al. Among authors: paramo ja. Circulation. 2011 Dec 20;124(25):2909-19. doi: 10.1161/CIRCULATIONAHA.111.047100. Epub 2011 Nov 21. Circulation. 2011. PMID: 22104553
286 results