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Page 1
An antibiotic from an uncultured bacterium binds to an immutable target.
Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MGN, De Benedetti S, Krueger AM, Vermeulen BJA, Harbig T, Lavore F, Kumar R, Honorato RV, Grein F, Nieselt K, Liu Y, Bonvin AMJJ, Baldus M, Kubitscheck U, Breukink E, Achorn C, Nitti A, Schwalen CJ, Spoering AL, Ling LL, Hughes D, Lelli M, Roos WH, Lewis K, Schneider T, Weingarth M. Shukla R, et al. Cell. 2023 Sep 14;186(19):4059-4073.e27. doi: 10.1016/j.cell.2023.07.038. Epub 2023 Aug 22. Cell. 2023. PMID: 37611581 Free article.
A new antibiotic from an uncultured bacterium binds to an immutable target.
Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MGN, de Benedetti S, Krueger AM, Vermeulen BJA, Lavore F, Honorato RV, Grein F, Bonvin A, Kubitscheck U, Breukink E, Achorn C, Nitti A, Schwalen CJ, Spoering AL, Ling LL, Hughes D, Lelli M, Roos WH, Lewis K, Schneider T, Weingarth M. Shukla R, et al. bioRxiv [Preprint]. 2023 May 15:2023.05.15.540765. doi: 10.1101/2023.05.15.540765. bioRxiv. 2023. PMID: 37292624 Free PMC article. Updated. Preprint.
Computational identification of a systemic antibiotic for gram-negative bacteria.
Miller RD, Iinishi A, Modaresi SM, Yoo BK, Curtis TD, Lariviere PJ, Liang L, Son S, Nicolau S, Bargabos R, Morrissette M, Gates MF, Pitt N, Jakob RP, Rath P, Maier T, Malyutin AG, Kaiser JT, Niles S, Karavas B, Ghiglieri M, Bowman SEJ, Rees DC, Hiller S, Lewis K. Miller RD, et al. Nat Microbiol. 2022 Oct;7(10):1661-1672. doi: 10.1038/s41564-022-01227-4. Epub 2022 Sep 26. Nat Microbiol. 2022. PMID: 36163500 Free PMC article.
Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis.
Imai Y, Hauk G, Quigley J, Liang L, Son S, Ghiglieri M, Gates MF, Morrissette M, Shahsavari N, Niles S, Baldisseri D, Honrao C, Ma X, Guo JJ, Berger JM, Lewis K. Imai Y, et al. Nat Chem Biol. 2022 Nov;18(11):1236-1244. doi: 10.1038/s41589-022-01102-7. Epub 2022 Aug 22. Nat Chem Biol. 2022. PMID: 35996001 Free PMC article.
A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP.
Shahsavari N, Wang B, Imai Y, Mori M, Son S, Liang L, Böhringer N, Manuse S, Gates MF, Morrissette M, Corsetti R, Espinoza JL, Dupont CL, Laub MT, Lewis K. Shahsavari N, et al. mBio. 2022 Jun 28;13(3):e0070022. doi: 10.1128/mbio.00700-22. Epub 2022 May 16. mBio. 2022. PMID: 35575547 Free PMC article.
14 results