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The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.
Evans CM, Raclawska DS, Ttofali F, Liptzin DR, Fletcher AA, Harper DN, McGing MA, McElwee MM, Williams OW, Sanchez E, Roy MG, Kindrachuk KN, Wynn TA, Eltzschig HK, Blackburn MR, Tuvim MJ, Janssen WJ, Schwartz DA, Dickey BF. Evans CM, et al. Nat Commun. 2015 Feb 17;6:6281. doi: 10.1038/ncomms7281. Nat Commun. 2015. PMID: 25687754 Free PMC article.
Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression.
Zhang Y, Berka V, Song A, Sun K, Wang W, Zhang W, Ning C, Li C, Zhang Q, Bogdanov M, Alexander DC, Milburn MV, Ahmed MH, Lin H, Idowu M, Zhang J, Kato GJ, Abdulmalik OY, Zhang W, Dowhan W, Kellems RE, Zhang P, Jin J, Safo M, Tsai AL, Juneja HS, Xia Y. Zhang Y, et al. J Clin Invest. 2014 Jun;124(6):2750-61. doi: 10.1172/JCI74604. Epub 2014 May 16. J Clin Invest. 2014. PMID: 24837436 Free PMC article.