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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2009 1
2010 2
2011 1
2012 18
2013 29
2014 73
2015 107
2016 128
2017 107
2018 134
2019 70
2020 39
2021 10
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669 results
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Page 1
Identification of a potent and selective covalent Pin1 inhibitor.
Pinch BJ, Doctor ZM, Nabet B, Browne CM, Seo HS, Mohardt ML, Kozono S, Lian X, Manz TD, Chun Y, Kibe S, Zaidman D, Daitchman D, Yeoh ZC, Vangos NE, Geffken EA, Tan L, Ficarro SB, London N, Marto JA, Buratowski S, Dhe-Paganon S, Zhou XZ, Lu KP, Gray NS. Pinch BJ, et al. Nat Chem Biol. 2020 Sep;16(9):979-987. doi: 10.1038/s41589-020-0550-9. Epub 2020 Jun 1. Nat Chem Biol. 2020. PMID: 32483379 Free PMC article.
Functional characterization of a PROTAC directed against BRAF mutant V600E.
Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, Maier S, Kitaygorodsky J, Larsen B, Colwill K, Yin Z, Ceccarelli DF, Batey RA, Taipale M, Kurinov I, Uehling D, Wrana J, Durocher D, Gingras AC, Al-Awar R, Therrien M, Sicheri F. Posternak G, et al. Nat Chem Biol. 2020 Nov;16(11):1170-1178. doi: 10.1038/s41589-020-0609-7. Epub 2020 Aug 10. Nat Chem Biol. 2020. PMID: 32778845 Free PMC article.
Structural basis for microRNA targeting.
Schirle NT, Sheu-Gruttadauria J, MacRae IJ. Schirle NT, et al. Science. 2014 Oct 31;346(6209):608-13. doi: 10.1126/science.1258040. Science. 2014. PMID: 25359968 Free PMC article.
MEK drives BRAF activation through allosteric control of KSR proteins.
Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M. Lavoie H, et al. Nature. 2018 Feb 22;554(7693):549-553. doi: 10.1038/nature25478. Epub 2018 Feb 12. Nature. 2018. PMID: 29433126 Free PMC article.
669 results
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