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69 results

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Page 1
Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights.
Koutros S, Kiemeney LA, Pal Choudhury P, Milne RL, Lopez de Maturana E, Ye Y, Joseph V, Florez-Vargas O, Dyrskjøt L, Figueroa J, Dutta D, Giles GG, Hildebrandt MAT, Offit K, Kogevinas M, Weiderpass E, McCullough ML, Freedman ND, Albanes D, Kooperberg C, Cortessis VK, Karagas MR, Johnson A, Schwenn MR, Baris D, Furberg H, Bajorin DF, Cussenot O, Cancel-Tassin G, Benhamou S, Kraft P, Porru S, Carta A, Bishop T, Southey MC, Matullo G, Fletcher T, Kumar R, Taylor JA, Lamy P, Prip F, Kalisz M, Weinstein SJ, Hengstler JG, Selinski S, Harland M, Teo M, Kiltie AE, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Schned A, Lenz P, Riboli E, Brennan P, Tjønneland A, Otto T, Ovsiannikov D, Volkert F, Vermeulen SH, Aben KK, Galesloot TE, Turman C, De Vivo I, Giovannucci E, Hunter DJ, Hohensee C, Hunt R, Patel AV, Huang WY, Thorleifsson G, Gago-Dominguez M, Amiano P, Golka K, Stern MC; UROMOL Consortium; Yan W, Liu J, Li SA, Katta S, Hutchinson A, Hicks B, Wheeler WA, Purdue MP, McGlynn KA, Kitahara CM, Haiman CA, Greene MH, Rafnar T, Chatterjee N, Chanock SJ, Wu X, Real FX, Silverman DT, Garcia-Closas M, Stefansson K, Prokunina-Olsson L, Malats N, Rothman N. Koutros S, et al. Eur Urol. 2023 Jul;84(1):127-137. doi: 10.1016/j.eururo.2023.04.020. Epub 2023 May 19. Eur Urol. 2023. PMID: 37210288
BACKGROUND: Genomic regions identified by genome-wide association studies (GWAS) for bladder cancer risk provide new insights into etiology. OBJECTIVE: To identify new susceptibility variants for bladder cancer in a meta-analysis of new and existing genome-wide geno …
BACKGROUND: Genomic regions identified by genome-wide association studies (GWAS) for bladder cancer risk provide new insights into et …
PAG1 promotes the inherent radioresistance of laryngeal cancer cells via activation of STAT3.
Shen L, Ke Q, Chai J, Zhang C, Qiu L, Peng F, Deng X, Luo Z. Shen L, et al. Exp Cell Res. 2018 Sep 1;370(1):127-136. doi: 10.1016/j.yexcr.2018.06.014. Epub 2018 Jun 18. Exp Cell Res. 2018. PMID: 29913153
In this study, we found that PAG1 was significantly increased in laryngeal cancer tissues compared to adjacent non-tumor tissues (P < 0.05). ...High expression of PAG1 also predicted a poor prognosis in patients with laryngeal cancer. ...
In this study, we found that PAG1 was significantly increased in laryngeal cancer tissues compared to adjacent non-tumor tissu …
PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation.
Foltz L, Palacios-Moreno J, Mayfield M, Kinch S, Dillon J, Syrenne J, Levy T, Grimes M. Foltz L, et al. Mol Biol Cell. 2020 Sep 15;31(20):2269-2282. doi: 10.1091/mbc.E20-02-0135. Epub 2020 Jul 29. Mol Biol Cell. 2020. PMID: 32726167 Free PMC article.
We tested the hypothesis that regulation of SRC family kinase (SFK) signaling by the scaffold protein, PAG1, influences cell fate decisions following RTK activation. We generated a neuroblastoma cell line expressing a PAG1 fragment that lacks the membrane-spanning d …
We tested the hypothesis that regulation of SRC family kinase (SFK) signaling by the scaffold protein, PAG1, influences cell fate dec …
PAG1 stimulates proliferation and metastasis of nasopharyngeal carcinoma through downregulating PTEN.
Lin JJ, Fan JJ, Ge XJ, Sha HB. Lin JJ, et al. Eur Rev Med Pharmacol Sci. 2020 Nov;24(21):11096-11104. doi: 10.26355/eurrev_202011_23596. Eur Rev Med Pharmacol Sci. 2020. PMID: 33215426 Free article.
Knockdown of PAG1 blocked NPC cells to proliferate, migrate, and invade. Dual-Luciferase reporter gene assay indicated the binding relationship between PAG1 and PTEN. In addition, both mRNA and protein levels of PTEN were negatively regulated by PAG1 in NPC c …
Knockdown of PAG1 blocked NPC cells to proliferate, migrate, and invade. Dual-Luciferase reporter gene assay indicated the binding re …
[Screening of phosphoprotein associated with glycosphingolipid microdomains 1 (PAG1) by cDNA microarray and influence of overexpression of PAG1 on biologic behavior of human metastatic prostatic cancer cell line in vitro].
Yu WJ, Wang YW, Xie ZG, You JF, Wang JL, Cui XL, Pei F, Zheng J. Yu WJ, et al. Zhonghua Bing Li Xue Za Zhi. 2010 Feb;39(2):88-94. Zhonghua Bing Li Xue Za Zhi. 2010. PMID: 20388373 Chinese.
OBJECTIVE: To screen for novel gene(s) associated with tumor metastasis, and to investigate the effect of overexpression of phosphoprotein associated with glycosphingolipid microdomains 1 (PAG1) on the biological behaviors of human prostatic cancer cell line PC-3M-1 …
OBJECTIVE: To screen for novel gene(s) associated with tumor metastasis, and to investigate the effect of overexpression of phosphoprotein a …
Upregulation of PAG1/Cbp contributes to adipose-derived mesenchymal stem cells promoted tumor progression and chemoresistance in breast cancer.
Lu Y, Yang Y, Liu Y, Hao Y, Zhang Y, Hu Y, Jiang L, Gong Y, Wu K, Liu Y. Lu Y, et al. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):719-727. doi: 10.1016/j.bbrc.2017.10.118. Epub 2017 Oct 24. Biochem Biophys Res Commun. 2017. PMID: 29079189
Although SFKs are well known for their involvement in breast cancer, the function of Cbp in breast carcinogenesis upon the adipose-tumor microenvironment has not been investigated. ...Our study highlights the underlying mechanism of cross interaction between ASCs and breas …
Although SFKs are well known for their involvement in breast cancer, the function of Cbp in breast carcinogenesis upon the adipose-tu …
Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma.
Agarwal S, Ghosh R, Chen Z, Lakoma A, Gunaratne PH, Kim ES, Shohet JM. Agarwal S, et al. Oncotarget. 2016 Apr 26;7(17):24018-26. doi: 10.18632/oncotarget.8116. Oncotarget. 2016. PMID: 26993602 Free PMC article.
PAG1 knockdown in NB cells promotes proliferation and anchorage-independent colony formation with increased activation of AKT and ERK downstream of c-Src, while PAG1 overexpression significantly rescues these effects. In vivo, PAG1 overexpression significantl …
PAG1 knockdown in NB cells promotes proliferation and anchorage-independent colony formation with increased activation of AKT and ERK …
Identification of a novel lncRNA-miRNA-mRNA competing endogenous RNA network associated with prognosis of breast cancer.
Wan X, Hao S, Hu C, Qu R. Wan X, et al. J Biochem Mol Toxicol. 2022 Aug;36(8):e23089. doi: 10.1002/jbt.23089. Epub 2022 May 9. J Biochem Mol Toxicol. 2022. PMID: 35532246
WGCNA predicted that 823 lncRNAs and 1813 mRNAs were closely related to breast cancer. The lncRNA-miRNA-mRNA ceRNA network involved in breast cancer was constructed based on 27 lncRNA, 14 miRNAs, and 4 mRNAs. ...This study suggested that the prognosis risk model bas …
WGCNA predicted that 823 lncRNAs and 1813 mRNAs were closely related to breast cancer. The lncRNA-miRNA-mRNA ceRNA network involved i …
The role of phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) in regulating the progression of oral squamous cell carcinoma.
Sun Y, Yang X, Guan S, Ma T, Jiang Z, Gao M, Xu Y, Cong B. Sun Y, et al. Arch Oral Biol. 2023 Dec;156:105810. doi: 10.1016/j.archoralbio.2023.105810. Epub 2023 Sep 29. Arch Oral Biol. 2023. PMID: 37852106
DESIGN: Immunohistochemistry detected the expression of PAG1 in normal and tumor tissues. The PAG1 overexpressed OSCC cell lines were constructed by lentivirus transfection. ...RNA-seq revealed that PAG1 mainly modulated the mitophagy and autophagy pathway, a …
DESIGN: Immunohistochemistry detected the expression of PAG1 in normal and tumor tissues. The PAG1 overexpressed OSCC cell lin …
A novel hepatocellular carcinoma-specific mTORC1-related signature for anticipating prognosis and immunotherapy.
Chen E, Mo Y, Yi J, Liu J, Luo T, Li Z, Lin Z, Hu Y, Zou Z, Liu J. Chen E, et al. Aging (Albany NY). 2023 Aug 16;15(16):7933-7955. doi: 10.18632/aging.204862. Epub 2023 Aug 16. Aging (Albany NY). 2023. PMID: 37589508 Free PMC article.
The PAG1, LHFPL2, and FABP5 expression levels were obtained to construct a mTORC1 pathway-related model. ...When compared to the low HCC metastatic cell lines, the high HCC metastatic cell lines have overexpressed levels of PAG1, LHFPL2, and FABP5 expression. The ex …
The PAG1, LHFPL2, and FABP5 expression levels were obtained to construct a mTORC1 pathway-related model. ...When compared to the low …
69 results