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2002 1
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2013 7
2014 7
2015 8
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2017 8
2018 4
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2020 8
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2023 5
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76 results

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Page 1
A PAK5-DNPEP-USP4 axis dictates breast cancer growth and metastasis.
Geng N, Li Y, Zhang W, Wang F, Wang X, Jin Z, Xing Y, Li D, Zhang H, Li Y, Li X, Cheng M, Jin F, Li F. Geng N, et al. Int J Cancer. 2020 Feb 15;146(4):1139-1151. doi: 10.1002/ijc.32523. Epub 2019 Jun 20. Int J Cancer. 2020. PMID: 31219614 Free article.
Although clinically associated with the progression of multiple cancers, the biological function of p21-activated kinase 5 (PAK5) in breast cancer remains largely unknown. ...Consistently, analyses of clinical breast cancer specimens revealed significa …
Although clinically associated with the progression of multiple cancers, the biological function of p21-activated kinase 5 (PAK5 …
HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5.
Huo FC, Zhu ZM, Du WQ, Pan YJ, Jiang X, Kang MJ, Liu BW, Mou J, Pei DS. Huo FC, et al. Pharmacol Res. 2023 Sep;195:106863. doi: 10.1016/j.phrs.2023.106863. Epub 2023 Jul 20. Pharmacol Res. 2023. PMID: 37480971 Free article.
Human papillomavirus (HPV) infection is a causative agent of cervical cancer (CC). N6-methyladenosine (m6A) modification is implicated in carcinogenesis and tumor progression. ...ALKBH5-mediated m6A demethylation enhanced the expression of PAK5. The m6A reader YTHDF …
Human papillomavirus (HPV) infection is a causative agent of cervical cancer (CC). N6-methyladenosine (m6A) modification is implicate …
Human p21-activated kinase 5 (PAK5) expression and potential mechanisms in relevant cancers: Basic and clinical perspectives for molecular cancer therapeutics.
Li YK, Zou J, Ye DM, Zeng Y, Chen CY, Luo GF, Zeng X. Li YK, et al. Life Sci. 2020 Jan 15;241:117113. doi: 10.1016/j.lfs.2019.117113. Epub 2019 Dec 2. Life Sci. 2020. PMID: 31805288 Review.
Currently, many researches indicated that PAK5 was dysregulated in ovarian cancer, cervical cancer, melanoma, osteosarcoma, renal carcinoma, breast cancer, gastric cancer and so on, which was involved in cell proliferation, apoptosis, migration …
Currently, many researches indicated that PAK5 was dysregulated in ovarian cancer, cervical cancer, melanoma, osteosarc …
PAK5-mediated AIF phosphorylation inhibits its nuclear translocation and promotes breast cancer tumorigenesis.
Xing Y, Li Y, Hu B, Han F, Zhao X, Zhang H, Li Y, Li D, Li J, Jin F, Li F. Xing Y, et al. Int J Biol Sci. 2021 Mar 27;17(5):1315-1327. doi: 10.7150/ijbs.58102. eCollection 2021. Int J Biol Sci. 2021. PMID: 33867848 Free PMC article.
Although p21 activated kinase 5 (PAK5) is related to the progression of multiple cancers, its biological function in breast cancer remains unclear. ...Functionally, we demonstrate that PAK5-mediated AIF phosphorylation promotes the proliferation of bre …
Although p21 activated kinase 5 (PAK5) is related to the progression of multiple cancers, its biological function in breast …
PAK5 facilitates the proliferation, invasion and migration in colorectal cancer cells.
Huang S, Zhu Y, Wang C, Li X, Cui X, Tu S, You L, Fu J, Chen Z, Hu W, Gong W. Huang S, et al. Cancer Med. 2020 Jul;9(13):4777-4790. doi: 10.1002/cam4.3084. Epub 2020 May 8. Cancer Med. 2020. PMID: 32383357 Free PMC article.
Colorectal cancer (CRC) is the third-most common cancer around the world, accounting for approximately 10% of cancer-related mortality. ...Collectively, we pointed out a potential of PAK5 to serve as a novel therapeutic target in restricting CRC prolif …
Colorectal cancer (CRC) is the third-most common cancer around the world, accounting for approximately 10% of cancer-re …
PAK5 promotes the migration and invasion of cervical cancer cells by phosphorylating SATB1.
Huo FC, Pan YJ, Li TT, Mou J, Pei DS. Huo FC, et al. Cell Death Differ. 2019 Jun;26(6):994-1006. doi: 10.1038/s41418-018-0178-4. Epub 2018 Aug 6. Cell Death Differ. 2019. PMID: 30082769 Free PMC article.
p21-activated kinase 5 (PAK5) is involved in several oncogenic signaling pathways and its amplification or overexpression has been found in various types of cancer; however, the pathophysiologic role of PAK5 in cervical cancer (CC) remains elusive. ... …
p21-activated kinase 5 (PAK5) is involved in several oncogenic signaling pathways and its amplification or overexpression has been fo …
PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer.
Zhu G, Li X, Guo B, Ke Q, Dong M, Li F. Zhu G, et al. Oncogene. 2016 Apr 14;35(15):1943-54. doi: 10.1038/onc.2015.259. Epub 2015 Jul 27. Oncogene. 2016. PMID: 26212009
However, the relationship between PAK5 and E47 has not been explored. In this study, we found that PAK5-mediated E47 phosphorylation promoted EMT in advanced colon cancer. ...Collectively, E47 is a novel substrate of PAK5, and PAK5-mediated phos …
However, the relationship between PAK5 and E47 has not been explored. In this study, we found that PAK5-mediated E47 phosphory …
PAK5-mediated phosphorylation and nuclear translocation of NF-kappaB-p65 promotes breast cancer cell proliferation in vitro and in vivo.
Zhang YC, Huo FC, Wei LL, Gong CC, Pan YJ, Mou J, Pei DS. Zhang YC, et al. J Exp Clin Cancer Res. 2017 Oct 17;36(1):146. doi: 10.1186/s13046-017-0610-5. J Exp Clin Cancer Res. 2017. PMID: 29041983 Free PMC article.
METHODS: We evaluated PAK5 and p65 staining in breast cancer tissues (BCTs) and paired non-cancerous tissues (NTs) using tissue microarray (TMA) technology. ...Xenograft models in nude mice were established to explore the roles of PAK5 in breast can …
METHODS: We evaluated PAK5 and p65 staining in breast cancer tissues (BCTs) and paired non-cancerous tissues (NTs) usin …
PAK5 promotes the cell stemness ability by phosphorylating SOX2 in lung squamous cell carcinomas.
Bao Z, Ji W, Yang Y, Chen Z, Li Z, Wang K, Lu T, Yu Y, Xia W, Lu S. Bao Z, et al. Exp Cell Res. 2020 Oct 15;395(2):112187. doi: 10.1016/j.yexcr.2020.112187. Epub 2020 Jul 25. Exp Cell Res. 2020. PMID: 32721391
Taken together, our findings suggest that the PAK5-mediated SOX2 phosphorylation promoted the cancer stem cell-like phenotype of LUSC cells. PAK5 inhibition may be a promising target in the treatment of SOX2 positive lung squamous cell cancer....
Taken together, our findings suggest that the PAK5-mediated SOX2 phosphorylation promoted the cancer stem cell-like phenotype …
An oncogenic kinase: putting PAK5 forward.
Wen YY, Zheng JN, Pei DS. Wen YY, et al. Expert Opin Ther Targets. 2014 Jul;18(7):807-15. doi: 10.1517/14728222.2014.918103. Epub 2014 May 29. Expert Opin Ther Targets. 2014. PMID: 24869804 Review.
AREAS COVERED: This review discusses the current understanding of PAK5 functions as an oncogenic kinase in tumor cellular regulation. ...Overexpression of PAK5 has been found in several tumors, probably due to its contribution to proliferation, cytoskeleton and anti …
AREAS COVERED: This review discusses the current understanding of PAK5 functions as an oncogenic kinase in tumor cellular regulation. …
76 results