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2004 1
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Page 1
How autophagy controls the intestinal epithelial barrier.
Foerster EG, Mukherjee T, Cabral-Fernandes L, Rocha JDB, Girardin SE, Philpott DJ. Foerster EG, et al. Autophagy. 2022 Jan;18(1):86-103. doi: 10.1080/15548627.2021.1909406. Epub 2021 Apr 27. Autophagy. 2022. PMID: 33906557 Free PMC article. Review.
Here, we review the physiological role of autophagy in the context of intestinal epithelial maintenance and how genetic mutations affecting autophagy contribute to the development of intestinal disease.Abbreviations: AKT1S1: AKT1 substrate 1; AMBRA1: autophagy and beclin 1 regula …
Here, we review the physiological role of autophagy in the context of intestinal epithelial maintenance and how genetic mutations affecting …
Viral manipulation of cell polarity signalling.
Javorsky A, Humbert PO, Kvansakul M. Javorsky A, et al. Biochim Biophys Acta Mol Cell Res. 2023 Oct;1870(7):119536. doi: 10.1016/j.bbamcr.2023.119536. Epub 2023 Jul 14. Biochim Biophys Acta Mol Cell Res. 2023. PMID: 37437846 Free article. Review.
This is associated with a poor prognosis due to viral interference with core cell polarity regulatory scaffolding proteins that often feature PDZ (PSD-95, DLG, and ZO-1) domains including Scrib, Dlg, Pals1, PatJ, Par3 and Par6. PDZ domains are also promiscuous, binding to …
This is associated with a poor prognosis due to viral interference with core cell polarity regulatory scaffolding proteins that often featur …
Cell Polarity Protein Pals1-Associated Tight Junction Expression Is a Favorable Prognostic Marker in Clear Cell Renal Cell Carcinoma.
Li P, Lan P, Liu S, Wang Y, Liu P. Li P, et al. Front Genet. 2020 Aug 28;11:931. doi: 10.3389/fgene.2020.00931. eCollection 2020. Front Genet. 2020. PMID: 33005169 Free PMC article.
The PATJ mRNA data in ccRCC were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases and analyzed with UALCAN, LinkedOmics, Kaplan-Meier Plotter, GEPIA, and SurvExpress tools. ...Results: The data showed that PATJ mRNA and …
The PATJ mRNA data in ccRCC were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases and …
Cell polarity proteins: common targets for tumorigenic human viruses.
Javier RT. Javier RT. Oncogene. 2008 Nov 24;27(55):7031-46. doi: 10.1038/onc.2008.352. Oncogene. 2008. PMID: 19029943 Free PMC article. Review.
Loss of polarity and disruption of cell junctions are common features of epithelial-derived cancer cells, and mounting evidence indicates that such defects have a direct function in the pathology of cancer. ...Underscoring the significance of these observations, in …
Loss of polarity and disruption of cell junctions are common features of epithelial-derived cancer cells, and mounting evidence indic …
Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis.
Fahey-Lozano N, La Marca JE, Portela M, Richardson HE. Fahey-Lozano N, et al. Adv Exp Med Biol. 2019;1167:37-64. doi: 10.1007/978-3-030-23629-8_3. Adv Exp Med Biol. 2019. PMID: 31520348 Review.
Among them are genes required for the establishment and maintenance of apico-basal cell polarity: the Crumbs/Stardust/Patj (Crb/Sdt/Patj), Bazooka/Par-6/atypical Protein Kinase C (Baz/Par-6/aPKC), and Scribbled/Discs large 1/Lethal (2) giant larvae (Scrib/Dlg1/L(2)g …
Among them are genes required for the establishment and maintenance of apico-basal cell polarity: the Crumbs/Stardust/Patj (Crb/Sdt/ …
Cell competition in vertebrate organ size regulation.
Penzo-Méndez AI, Stanger BZ. Penzo-Méndez AI, et al. Wiley Interdiscip Rev Dev Biol. 2014 Nov-Dec;3(6):419-27. doi: 10.1002/wdev.148. Epub 2014 Aug 29. Wiley Interdiscip Rev Dev Biol. 2014. PMID: 25176591 Review.
These include Myc, the members of the Hippo, JAK/STAT and WNT signaling pathways, and the Dlg/Lgl/Scrib and the Crb/Std/PatJ membrane protein complexes. Cell competition was initially characterized in the Drosophila imaginal disc, but several recent studies have shown that …
These include Myc, the members of the Hippo, JAK/STAT and WNT signaling pathways, and the Dlg/Lgl/Scrib and the Crb/Std/PatJ membrane …
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.
Ernkvist M, Luna Persson N, Audebert S, Lecine P, Sinha I, Liu M, Schlueter M, Horowitz A, Aase K, Weide T, Borg JP, Majumdar A, Holmgren L. Ernkvist M, et al. Blood. 2009 Jan 1;113(1):244-53. doi: 10.1182/blood-2008-04-153874. Epub 2008 Sep 29. Blood. 2009. PMID: 18824598 Free PMC article.
We report that Amot and its related proteins bind to the RhoA GTPase exchange factor (RhoGEF) protein Syx. We show that Amot forms a ternary complex together with Patj (or its paralogue Mupp1) and Syx. Using FRET analysis, we provide evidence that Amot controls targeting o …
We report that Amot and its related proteins bind to the RhoA GTPase exchange factor (RhoGEF) protein Syx. We show that Amot forms a ternary …
25 results