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PDGFA-associated protein 1 is a novel target of c-Myc and contributes to colorectal cancer initiation and progression.
Cui HY, Wei W, Qian MR, Tian RF, Fu X, Li HW, Nan G, Yang T, Lin P, Chen X, Zhu YM, Wang B, Sun XX, Dou JH, Jiang JL, Li L, Wang SJ, Chen ZN. Cui HY, et al. Cancer Commun (Lond). 2022 Aug;42(8):750-767. doi: 10.1002/cac2.12322. Epub 2022 Jun 18. Cancer Commun (Lond). 2022. PMID: 35716012 Free PMC article.
Previous studies have shown that PDGFA-associated protein 1 (PDAP1) is upregulated in several cancers including CRC. Here, we aimed to identify the cause and consequence of PDAP1 dysregulation in CRC and evaluate its role as a potential therapeutic target. .. …
Previous studies have shown that PDGFA-associated protein 1 (PDAP1) is upregulated in several cancers including CRC. Here, we …
SILAC-based quantitative proteomic analysis of gastric cancer secretome.
Marimuthu A, Subbannayya Y, Sahasrabuddhe NA, Balakrishnan L, Syed N, Sekhar NR, Katte TV, Pinto SM, Srikanth SM, Kumar P, Pawar H, Kashyap MK, Maharudraiah J, Ashktorab H, Smoot DT, Ramaswamy G, Kumar RV, Cheng Y, Meltzer SJ, Roa JC, Chaerkady R, Prasad TS, Harsha HC, Chatterjee A, Pandey A. Marimuthu A, et al. Proteomics Clin Appl. 2013 Jun;7(5-6):355-66. doi: 10.1002/prca.201200069. Epub 2013 May 21. Proteomics Clin Appl. 2013. PMID: 23161554 Free PMC article.
PURPOSE: Gastric cancer is a commonly occurring cancer in Asia and one of the leading causes of cancer deaths. However, there is no reliable blood-based screening test for this cancer. Identifying proteins secreted from tumor cells could lead to the di …
PURPOSE: Gastric cancer is a commonly occurring cancer in Asia and one of the leading causes of cancer deaths. However, …
Programming a Ferroptosis-to-Apoptosis Transition Landscape Revealed Ferroptosis Biomarkers and Repressors for Cancer Therapy.
Vinik Y, Maimon A, Dubey V, Raj H, Abramovitch I, Malitsky S, Itkin M, Ma'ayan A, Westermann F, Gottlieb E, Ruppin E, Lev S. Vinik Y, et al. Adv Sci (Weinh). 2024 May;11(17):e2307263. doi: 10.1002/advs.202307263. Epub 2024 Mar 5. Adv Sci (Weinh). 2024. PMID: 38441406 Free PMC article.
A subset of the GGS is associated with poor prognosis in breast cancer patients and PDXs and contains different ferroptosis repressors. Depletion of one representative, PDGFA-assaociated protein 1(PDAP1), is found to suppress basal-like breast tumor growth in a mous …
A subset of the GGS is associated with poor prognosis in breast cancer patients and PDXs and contains different ferroptosis repressor …
Synergistic action of dual IGF1/R and MEK inhibition sensitizes childhood acute lymphoblastic leukemia (ALL) cells to cytotoxic agents and involves downregulation of STAT6 and PDAP1.
Weston VJ, Wei W, Stankovic T, Kearns P. Weston VJ, et al. Exp Hematol. 2018 Jul;63:52-63.e5. doi: 10.1016/j.exphem.2018.04.002. Epub 2018 Apr 12. Exp Hematol. 2018. PMID: 29656114 Free PMC article.
Knockdown studies revealed that loss of STAT6, but not PDAP1, impinges on the cell cycle, causing reduced numbers of viable cells. In combination with daunorubicin, STAT6 loss has an additive effect on cell killing, whereas PDAP1 loss is synergistic, indicating an i …
Knockdown studies revealed that loss of STAT6, but not PDAP1, impinges on the cell cycle, causing reduced numbers of viable cells. In …
Pancreatic ductal adenocarcinoma cells regulated the gemcitabine-resistance function of CAFs by LINC00460.
Zhu XX, Li JH, Ni X, Wu X, Hou X, Li YX, Li SJ, Zhao W, Yin XY. Zhu XX, et al. Cancer Sci. 2022 Nov;113(11):3735-3750. doi: 10.1111/cas.15547. Epub 2022 Sep 15. Cancer Sci. 2022. PMID: 36047966 Free PMC article.
Results of RNA pull-down, LC-MS/MS, RIP, and immunoblotting confirmed that LINC00460 could directly bind to PDAP1. Furthermore, we demonstrated that LINC00460 mediated the cellular communication of PDAC tumor cells and CAFs by PDAP1/PDGFA/PDGFR signaling pathway and …
Results of RNA pull-down, LC-MS/MS, RIP, and immunoblotting confirmed that LINC00460 could directly bind to PDAP1. Furthermore, we de …
PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito V, Berruezo-Llacuna M, Altwasser R, Winkler W, Sundaravinayagam D, Balasubramanian S, Caganova M, Graf R, Rahjouei A, Henke MT, Driesner M, Keller L, Prigione A, Janz M, Akalin A, Di Virgilio M. Delgado-Benito V, et al. J Exp Med. 2020 Oct 5;217(10):e20200137. doi: 10.1084/jem.20200137. J Exp Med. 2020. PMID: 32609329 Free PMC article.
As a consequence, loss of Pdap1 reduces germinal center B cell formation and impairs CSR and SHM. Thus, Pdap1 protects mature B cells against chronic ISR activation and ensures efficient antibody diversification by promoting their survival and optimal function....
As a consequence, loss of Pdap1 reduces germinal center B cell formation and impairs CSR and SHM. Thus, Pdap1 protects mature …
Downregulation of PTCD1 in Bladder Urothelial Carcinoma Predicts Poor Prognosis and Levels of Immune Infiltration.
Zhou Z, Zhou Y, Zhou X, Huang Y, Cui Y, Zhang Y. Zhou Z, et al. J Oncol. 2022 Jun 28;2022:1146186. doi: 10.1155/2022/1146186. eCollection 2022. J Oncol. 2022. PMID: 35799606 Free PMC article.
However, the effect and mechanism of PTCD1 in the development of bladder urothelial carcinoma (BLCA) remain unclear. The databases from The Cancer Genome Atlas (TCGA) and Human Protein Atlas (HPA) were used to analyze the expression changes, clinical features, and prognost …
However, the effect and mechanism of PTCD1 in the development of bladder urothelial carcinoma (BLCA) remain unclear. The databases from The …
Analysis of differentially expressed genes in human rectal carcinoma using suppression subtractive hybridization.
Choi SY, Jang JH, Kim KR. Choi SY, et al. Clin Exp Med. 2011 Dec;11(4):219-26. doi: 10.1007/s10238-010-0130-5. Epub 2011 Feb 18. Clin Exp Med. 2011. PMID: 21331762
The existence and treatment of rectal cancer are important for the function of defecation and the quality of life. ...The expression profiles of the genes were further confirmed in rectal carcinoma cells and the corresponding normal rectal cells of 12 patients by quantitat …
The existence and treatment of rectal cancer are important for the function of defecation and the quality of life. ...The expression …
Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics.
Olsen JB, Cao XJ, Han B, Chen LH, Horvath A, Richardson TI, Campbell RM, Garcia BA, Nguyen H. Olsen JB, et al. Mol Cell Proteomics. 2016 Mar;15(3):892-905. doi: 10.1074/mcp.M115.053280. Epub 2016 Jan 10. Mol Cell Proteomics. 2016. PMID: 26750096 Free PMC article.
In addition, we report specific protein sequence motifs enriched in Kme1 sites that are directly regulated by endogenous SMYD2 activity, revealing that SMYD2 substrate specificity is more diverse than expected. We further show direct activity of SMYD2 toward BTF3-K2, PDAP1 …
In addition, we report specific protein sequence motifs enriched in Kme1 sites that are directly regulated by endogenous SMYD2 activity, rev …
11 results