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2012 1
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Page 1
PDCD2 functions in cancer cell proliferation and predicts relapsed leukemia.
Barboza N, Minakhina S, Medina DJ, Balsara B, Greenwood S, Huzzy L, Rabson AB, Steward R, Schaar DG. Barboza N, et al. Cancer Biol Ther. 2013 Jun;14(6):546-55. doi: 10.4161/cbt.24484. Cancer Biol Ther. 2013. PMID: 23760497 Free PMC article.
Based on the above observations we have focused on the role of PDCD2 in human cancer cell proliferation and hypothesized that aberrant PDCD2 expression may be characteristic of human malignancies. ...PDCD2 knockdown in cancer cells impairs their …
Based on the above observations we have focused on the role of PDCD2 in human cancer cell proliferation and hypothesized that …
Melanoma.
Schadendorf D, Fisher DE, Garbe C, Gershenwald JE, Grob JJ, Halpern A, Herlyn M, Marchetti MA, McArthur G, Ribas A, Roesch A, Hauschild A. Schadendorf D, et al. Nat Rev Dis Primers. 2015 Apr 23;1:15003. doi: 10.1038/nrdp.2015.3. Nat Rev Dis Primers. 2015. PMID: 27188223 Review.
Melanoma is a common cancer in the Western world with an increasing incidence. Sun exposure is still considered to be the major risk factor for melanoma. ...
Melanoma is a common cancer in the Western world with an increasing incidence. Sun exposure is still considered to be the major risk …
Proteomics-Based Discovery of First-in-Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2).
Ji W, Byun WS, Lu W, Zhu X, Donovan KA, Dwyer BG, Che J, Yuan L, Abulaiti X, Corsello SM, Fischer ES, Zhang T, Gray NS. Ji W, et al. Angew Chem Int Ed Engl. 2023 Oct 23;62(43):e202308292. doi: 10.1002/anie.202308292. Epub 2023 Sep 15. Angew Chem Int Ed Engl. 2023. PMID: 37658265
Here we report the discovery and characterization of 10 e, a first-in-class small molecule degrader of PDCD2. We discovered this PDCD2 degrader by serendipity using a chemical proteomics approach, in contrast to the conventional approach for making bivalent degrader …
Here we report the discovery and characterization of 10 e, a first-in-class small molecule degrader of PDCD2. We discovered this P …
PDCD2 and NCoR1 as putative tumor suppressors in gastric gastrointestinal stromal tumors.
Wang W, Song XW, Bu XM, Zhang N, Zhao CH. Wang W, et al. Cell Oncol (Dordr). 2016 Apr;39(2):129-37. doi: 10.1007/s13402-015-0258-0. Epub 2015 Nov 20. Cell Oncol (Dordr). 2016. PMID: 26589942
PURPOSE: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal tract. Previously, PDCD2 (programmed cell death protein 2) has been identified as a putative tumor suppressor in gastric cancer. ...Furthermore, we found …
PURPOSE: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal tract. Previously, PDCD2 …
PDCD2 sensitizes HepG2 cells to sorafenib by suppressing epithelial-mesenchymal transition.
Liu H, Wang M, Liang N, Guan L. Liu H, et al. Mol Med Rep. 2019 Mar;19(3):2173-2179. doi: 10.3892/mmr.2019.9860. Epub 2019 Jan 15. Mol Med Rep. 2019. PMID: 30664177 Free PMC article.
Epithelial-mesenchymal transition (EMT) has an established role in the acquisition of therapeutic resistance. Programmed cell death domain 2 (PDCD2) is involved in the progression of multiple types of cancer. ...PDCD2 may serve as a potential therapeutic targ …
Epithelial-mesenchymal transition (EMT) has an established role in the acquisition of therapeutic resistance. Programmed cell death domain 2 …
Zfrp8/PDCD2 Interacts with RpS2 Connecting Ribosome Maturation and Gene-Specific Translation.
Minakhina S, Naryshkina T, Changela N, Tan W, Steward R. Minakhina S, et al. PLoS One. 2016 Jan 25;11(1):e0147631. doi: 10.1371/journal.pone.0147631. eCollection 2016. PLoS One. 2016. PMID: 26807849 Free PMC article.
Zfrp8/PDCD2 is a highly conserved protein essential for stem cell maintenance in both flies and mammals. ...We also show that Zfrp8/PDCD2 interacts with the (40S) small ribosomal subunit through direct interaction with RpS2 (uS5). ...
Zfrp8/PDCD2 is a highly conserved protein essential for stem cell maintenance in both flies and mammals. ...We also show that Zfrp8/ …
Significance of liquid-liquid phase separation (LLPS)-related genes in breast cancer: a multi-omics analysis.
Xie J, Chen L, Wu D, Liu S, Pei S, Tang Q, Wang Y, Ou M, Zhu Z, Ruan S, Wang M, Shi J. Xie J, et al. Aging (Albany NY). 2023 Jun 19;15(12):5592-5610. doi: 10.18632/aging.204812. Epub 2023 Jun 19. Aging (Albany NY). 2023. PMID: 37338518 Free PMC article.
Currently, the role of liquid-liquid phase separation (LLPS) in cancer has been preliminarily explained. However, the significance of LLPS in breast cancer is unclear. In this study, single cell sequencing datasets GSE188600 and GSE198745 for breast cancer we …
Currently, the role of liquid-liquid phase separation (LLPS) in cancer has been preliminarily explained. However, the significance of …
The roles of APOBEC3B in gastric cancer.
Zhang J, Wei W, Jin HC, Ying RC, Zhu AK, Zhang FJ. Zhang J, et al. Int J Clin Exp Pathol. 2015 May 1;8(5):5089-96. eCollection 2015. Int J Clin Exp Pathol. 2015. PMID: 26191203 Free PMC article.
Furthermore, APOBEC3B expression was associated with gender, tumor size, histological grade, T stage, and TNM staging of the patients with gastric cancer. Down-regulation of APOBEC3B expression in MNK28 cells could enhance the cytotoxicity of PDCD2. No editing took …
Furthermore, APOBEC3B expression was associated with gender, tumor size, histological grade, T stage, and TNM staging of the patients with g …
Programmed cell death 2 protein induces gastric cancer cell growth arrest at the early S phase of the cell cycle and apoptosis in a p53-dependent manner.
Zhang J, Wei W, Jin HC, Ying RC, Zhu AK, Zhang FJ. Zhang J, et al. Oncol Rep. 2015 Jan;33(1):103-10. doi: 10.3892/or.2014.3551. Epub 2014 Oct 17. Oncol Rep. 2015. PMID: 25334010
The present study aimed to investigate PDCD2 expression in gastric cancer. Tissue specimens from 34 gastric cancer patients were collected for analysis of PDCD2 expression using immunohistochemistry, western blotting and qRT-PCR. ...The antitumor effec …
The present study aimed to investigate PDCD2 expression in gastric cancer. Tissue specimens from 34 gastric cancer pati …
PDCD2 knockdown inhibits erythroid but not megakaryocytic lineage differentiation of human hematopoietic stem/progenitor cells.
Kokorina NA, Granier CJ, Zakharkin SO, Davis S, Rabson AB, Sabaawy HE. Kokorina NA, et al. Exp Hematol. 2012 Dec;40(12):1028-1042.e3. doi: 10.1016/j.exphem.2012.08.004. Epub 2012 Aug 22. Exp Hematol. 2012. PMID: 22922207 Free PMC article.
We investigated the effects of PDCD2 knockdown on the development and differentiation of hematopoietic progenitor cells (HPC). ...These findings suggest that PDCD2 has a novel regulatory role in human hematopoiesis and is essential for erythroid development....
We investigated the effects of PDCD2 knockdown on the development and differentiation of hematopoietic progenitor cells (HPC). ...The …
35 results