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23 results

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Page 1
Phosphodiesterase 7B/microRNA-200c relationship regulates triple-negative breast cancer cell growth.
Zhang DD, Li Y, Xu Y, Kim J, Huang S. Zhang DD, et al. Oncogene. 2019 Feb;38(7):1106-1120. doi: 10.1038/s41388-018-0499-2. Epub 2018 Sep 12. Oncogene. 2019. PMID: 30209363 Free PMC article.
We identified phosphodiesterase 7B (PDE7B) as a bona fide miR-200c target. Importantly, miR-200c-led inhibition in cell growth and tumor development was prevented by forcing PDE7B transgene expression, while knockdown of PDE7B effectively inhibited cell growt …
We identified phosphodiesterase 7B (PDE7B) as a bona fide miR-200c target. Importantly, miR-200c-led inhibition in cell growth and tu …
The mechanism of PDE7B inhibiting the development of hepatocellular carcinoma through oxidative stress.
Luo Y, Gao H, Zhao J, Chen L, Shao J, Ju L. Luo Y, et al. Front Immunol. 2024 Nov 21;15:1469740. doi: 10.3389/fimmu.2024.1469740. eCollection 2024. Front Immunol. 2024. PMID: 39640266 Free PMC article.
METHODS: Real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) and Western blotting were employed to analyze the expression of PDE7B in hepatocellular carcinoma tissues and cells. The biological role of PDE7B in HCC was investigated by both overexp …
METHODS: Real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) and Western blotting were employed to analyze the expressio …
Methylation-regulated tumor suppressor gene PDE7B promotes HCC invasion and metastasis through the PI3K/AKT signaling pathway.
Du Y, Xu Y, Guo X, Tan C, Zhu X, Liu G, Lyu X, Bei C. Du Y, et al. BMC Cancer. 2024 May 22;24(1):624. doi: 10.1186/s12885-024-12364-w. BMC Cancer. 2024. PMID: 38778317 Free PMC article.
In addition, DNA methylation regulates PDE7B expression in HCC. On the contrary, overexpression of PDE7B inhibited tumor proliferation and metastasis in vitro. In addition, PDE7B-related genes were mainly enriched in the PI3K/ATK signaling pathway, and PDE …
In addition, DNA methylation regulates PDE7B expression in HCC. On the contrary, overexpression of PDE7B inhibited tumor proli …
The Prognostic Significance of PDE7B in Cytogenetically Normal Acute Myeloid Leukemia.
Cao L, Zhang W, Liu X, Yang P, Wang J, Hu K, Zhang X, Liu W, He X, Jing H, Yuan X. Cao L, et al. Sci Rep. 2019 Nov 18;9(1):16991. doi: 10.1038/s41598-019-53563-x. Sci Rep. 2019. PMID: 31740742 Free PMC article.
And we detected a significantly higher expression level of PDE7B in the leukemia stem cell (LSC) positive group. The Cox proportional hazards regression model showed that PDE7B is an independent risk predictor for CN-AML. All results indicate that PDE7B is an …
And we detected a significantly higher expression level of PDE7B in the leukemia stem cell (LSC) positive group. The Cox proportional …
Identification of PDE7B as a Potential Core Gene Involved in the Metastasis of Clear Cell Renal Cell Carcinoma.
Sun Y, Zou J, Ouyang W, Chen K. Sun Y, et al. Cancer Manag Res. 2020 Jul 12;12:5701-5712. doi: 10.2147/CMAR.S259192. eCollection 2020. Cancer Manag Res. 2020. PMID: 32765073 Free PMC article.
Moreover, the low expression of PDE7B was found in clinical ccRCC samples and correlated with TNM stage and histologic grade. We further showed that knockdown of PDE7B increased cell growth and migration of renal cancer cells. CONCLUSION: Our results implicat …
Moreover, the low expression of PDE7B was found in clinical ccRCC samples and correlated with TNM stage and histologic grade. We furt …
Identification of Prostate Cancer-Related Circular RNA Through Bioinformatics Analysis.
Wu YP, Lin XD, Chen SH, Ke ZB, Lin F, Chen DN, Xue XY, Wei Y, Zheng QS, Wen YA, Xu N. Wu YP, et al. Front Genet. 2020 Aug 14;11:892. doi: 10.3389/fgene.2020.00892. eCollection 2020. Front Genet. 2020. PMID: 32922436 Free PMC article.
BACKGROUND: Prostate cancer (PCa) is one of the most common malignant tumors worldwide. Accumulating evidence has suggested that circular RNAs (circRNAs) are involved in the development and progression of various cancers, and they show great potential as novel bioma …
BACKGROUND: Prostate cancer (PCa) is one of the most common malignant tumors worldwide. Accumulating evidence has suggested that circ …
PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells.
Brooks MD, Jackson E, Warrington NM, Luo J, Forys JT, Taylor S, Mao DD, Leonard JR, Kim AH, Piwnica-Worms D, Mitra RD, Rubin JB. Brooks MD, et al. PLoS One. 2014 Sep 9;9(9):e107397. doi: 10.1371/journal.pone.0107397. eCollection 2014. PLoS One. 2014. PMID: 25203500 Free PMC article.
Using a computational approach, we deconvoluted expression data from a mixed physical co-culture of GBM cells and ECs and identified a previously undescribed upregulation of the cAMP specific phosphodiesterase PDE7B in GBM cells in response to direct contact with ECs. We f …
Using a computational approach, we deconvoluted expression data from a mixed physical co-culture of GBM cells and ECs and identified a previ …
Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Exerts Anti-Breast Cancer Effect via miR-200c-PDE7B/PD-L1-AKT/MAPK Axis.
Yang Y, Fang T, Cao YL, Lv YX, Chang QQ, Zhang DD. Yang Y, et al. Evid Based Complement Alternat Med. 2020 Aug 19;2020:3587095. doi: 10.1155/2020/3587095. eCollection 2020. Evid Based Complement Alternat Med. 2020. PMID: 32922506 Free PMC article.
Don in different ratios have been frequently used to treat various cancers in clinical Traditional Chinese Medicine prescriptions. However, the optimal ratio, active fraction, and molecular mechanisms associated with the anti-breast cancer role of this herbal couple …
Don in different ratios have been frequently used to treat various cancers in clinical Traditional Chinese Medicine prescriptions. Ho …
Cyclic nucleotide phosphodiesterase 7B mRNA: an unfavorable characteristic in chronic lymphocytic leukemia.
Zhang L, Murray F, Rassenti LZ, Pu M, Kelly C, Kanter JR, Greaves A, Messer K, Kipps TJ, Insel PA. Zhang L, et al. Int J Cancer. 2011 Sep 1;129(5):1162-9. doi: 10.1002/ijc.25785. Epub 2011 Feb 11. Int J Cancer. 2011. PMID: 21120911 Free PMC article.
On the basis of the evidence that CLL cells have enhanced expression of the cyclic nucleotide phosphodiesterase isoform 7B (PDE7B), we hypothesized that PDE7B expression might provide such information. We assessed PDE7B mRNA expression using quantitative real …
On the basis of the evidence that CLL cells have enhanced expression of the cyclic nucleotide phosphodiesterase isoform 7B (PDE7B), w …
Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia.
Zhang L, Murray F, Zahno A, Kanter JR, Chou D, Suda R, Fenlon M, Rassenti L, Cottam H, Kipps TJ, Insel PA. Zhang L, et al. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19532-7. doi: 10.1073/pnas.0806152105. Epub 2008 Nov 25. Proc Natl Acad Sci U S A. 2008. PMID: 19033455 Free PMC article.
Increased PDE7B mRNA in CLL correlates with a 10-fold-higher expression of PDE7B protein and results in an increased contribution of PDE7 to total PDE activity. ...Apoptosis of CLL cells promoted by inhibitors of PDE7 and PDE4/7 is attenuated by PKA inhibition, occu …
Increased PDE7B mRNA in CLL correlates with a 10-fold-higher expression of PDE7B protein and results in an increased contribut …
23 results