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Phosphodiesterase 7B/microRNA-200c relationship regulates triple-negative breast cancer cell growth.
Zhang DD, Li Y, Xu Y, Kim J, Huang S. Zhang DD, et al. Oncogene. 2019 Feb;38(7):1106-1120. doi: 10.1038/s41388-018-0499-2. Epub 2018 Sep 12. Oncogene. 2019. PMID: 30209363 Free PMC article.
Analysis of breast tumor gene expression datasets revealed an inverse association between miR-200c and PDE7B expression. Especially, both low miR-200c and high PDE7B expression were correlated with poor survival of breast cancer patients. Our study supports a …
Analysis of breast tumor gene expression datasets revealed an inverse association between miR-200c and PDE7B expression. Especially, …
The Prognostic Significance of PDE7B in Cytogenetically Normal Acute Myeloid Leukemia.
Cao L, Zhang W, Liu X, Yang P, Wang J, Hu K, Zhang X, Liu W, He X, Jing H, Yuan X. Cao L, et al. Sci Rep. 2019 Nov 18;9(1):16991. doi: 10.1038/s41598-019-53563-x. Sci Rep. 2019. PMID: 31740742 Free PMC article.
And we detected a significantly higher expression level of PDE7B in the leukemia stem cell (LSC) positive group. The Cox proportional hazards regression model showed that PDE7B is an independent risk predictor for CN-AML. All results indicate that PDE7B is an …
And we detected a significantly higher expression level of PDE7B in the leukemia stem cell (LSC) positive group. The Cox proportional …
Identification of PDE7B as a Potential Core Gene Involved in the Metastasis of Clear Cell Renal Cell Carcinoma.
Sun Y, Zou J, Ouyang W, Chen K. Sun Y, et al. Cancer Manag Res. 2020 Jul 12;12:5701-5712. doi: 10.2147/CMAR.S259192. eCollection 2020. Cancer Manag Res. 2020. PMID: 32765073 Free PMC article.
We further showed that knockdown of PDE7B increased cell growth and migration of renal cancer cells. CONCLUSION: Our results implicated that PDE7B may play a key role in the development of metastatic RCC....
We further showed that knockdown of PDE7B increased cell growth and migration of renal cancer cells. CONCLUSION: Our results i …
Phosphodiesterase sequence variants may predispose to prostate cancer.
de Alexandre RB, Horvath AD, Szarek E, Manning AD, Leal LF, Kardauke F, Epstein JA, Carraro DM, Soares FA, Apanasovich TV, Stratakis CA, Faucz FR. de Alexandre RB, et al. Endocr Relat Cancer. 2015 Aug;22(4):519-30. doi: 10.1530/ERC-15-0134. Epub 2015 May 15. Endocr Relat Cancer. 2015. PMID: 25979379 Free PMC article.
We hypothesized that mutations that inactivate phosphodiesterase (PDE) activity and lead to increased cAMP and cyclic guanosine monophosphate levels may be associated with prostate cancer (PCa). We sequenced the entire PDE coding sequences in the DNA of 16 biopsy samples f …
We hypothesized that mutations that inactivate phosphodiesterase (PDE) activity and lead to increased cAMP and cyclic guanosine monophosphat …
Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Exerts Anti-Breast Cancer Effect via miR-200c-PDE7B/PD-L1-AKT/MAPK Axis.
Yang Y, Fang T, Cao YL, Lv YX, Chang QQ, Zhang DD. Yang Y, et al. Evid Based Complement Alternat Med. 2020 Aug 19;2020:3587095. doi: 10.1155/2020/3587095. eCollection 2020. Evid Based Complement Alternat Med. 2020. PMID: 32922506 Free PMC article.
Don in different ratios have been frequently used to treat various cancers in clinical Traditional Chinese Medicine prescriptions. However, the optimal ratio, active fraction, and molecular mechanisms associated with the anti-breast cancer role of this herbal couple …
Don in different ratios have been frequently used to treat various cancers in clinical Traditional Chinese Medicine prescriptions. Ho …
Methylation-regulated tumor suppressor gene PDE7B promotes HCC invasion and metastasis through the PI3K/AKT signaling pathway.
Du Y, Xu Y, Guo X, Tan C, Zhu X, Liu G, Lyu X, Bei C. Du Y, et al. BMC Cancer. 2024 May 22;24(1):624. doi: 10.1186/s12885-024-12364-w. BMC Cancer. 2024. PMID: 38778317 Free PMC article.
In addition, DNA methylation regulates PDE7B expression in HCC. On the contrary, overexpression of PDE7B inhibited tumor proliferation and metastasis in vitro. ...CONCLUSION: PDE7B expression in HCC may be regulated by promoter methylation. ...
In addition, DNA methylation regulates PDE7B expression in HCC. On the contrary, overexpression of PDE7B inhibited tumor proli …
Novel insights into genetic susceptibility for colorectal cancer from transcriptome-wide association and functional investigation.
Chen Z, Song W, Shu XO, Wen W, Devall M, Dampier C, Moratalla-Navarro F, Cai Q, Long J, Van Kaer L, Wu L, Huyghe JR, Thomas M, Hsu L, Woods MO, Albanes D, Buchanan DD, Gsur A, Hoffmeister M, Vodicka P, Wolk A, Marchand LL, Wu AH, Phipps AI, Moreno V, Ulrike P, Zheng W, Casey G, Guo X. Chen Z, et al. J Natl Cancer Inst. 2024 Jan 10;116(1):127-137. doi: 10.1093/jnci/djad178. J Natl Cancer Inst. 2024. PMID: 37632791
BACKGROUND: Transcriptome-wide association studies have been successful in identifying candidate susceptibility genes for colorectal cancer (CRC). To strengthen susceptibility gene discovery, we conducted a large transcriptome-wide association study and an alternative spli …
BACKGROUND: Transcriptome-wide association studies have been successful in identifying candidate susceptibility genes for colorectal canc …
PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells.
Brooks MD, Jackson E, Warrington NM, Luo J, Forys JT, Taylor S, Mao DD, Leonard JR, Kim AH, Piwnica-Worms D, Mitra RD, Rubin JB. Brooks MD, et al. PLoS One. 2014 Sep 9;9(9):e107397. doi: 10.1371/journal.pone.0107397. eCollection 2014. PLoS One. 2014. PMID: 25203500 Free PMC article.
Using a computational approach, we deconvoluted expression data from a mixed physical co-culture of GBM cells and ECs and identified a previously undescribed upregulation of the cAMP specific phosphodiesterase PDE7B in GBM cells in response to direct contact with ECs. We f …
Using a computational approach, we deconvoluted expression data from a mixed physical co-culture of GBM cells and ECs and identified a previ …
Cyclic nucleotide phosphodiesterase 7B mRNA: an unfavorable characteristic in chronic lymphocytic leukemia.
Zhang L, Murray F, Rassenti LZ, Pu M, Kelly C, Kanter JR, Greaves A, Messer K, Kipps TJ, Insel PA. Zhang L, et al. Int J Cancer. 2011 Sep 1;129(5):1162-9. doi: 10.1002/ijc.25785. Epub 2011 Feb 11. Int J Cancer. 2011. PMID: 21120911 Free PMC article.
On the basis of the evidence that CLL cells have enhanced expression of the cyclic nucleotide phosphodiesterase isoform 7B (PDE7B), we hypothesized that PDE7B expression might provide such information. ...High expression of PDE7B is an unfavorable characteris …
On the basis of the evidence that CLL cells have enhanced expression of the cyclic nucleotide phosphodiesterase isoform 7B (PDE7B), w …
Phosphodiesterase 7 as a therapeutic target - Where are we now?
Zorn A, Baillie G. Zorn A, et al. Cell Signal. 2023 Aug;108:110689. doi: 10.1016/j.cellsig.2023.110689. Epub 2023 Apr 28. Cell Signal. 2023. PMID: 37120115 Free article. Review.
This review aims to collate the present knowledge on human PDE7 and outline its potential use as a therapeutic target. Human PDE7 exists as two isoforms PDE7A and PDE7B that display different expression patterns but are predominantly found in the central nervous system, im …
This review aims to collate the present knowledge on human PDE7 and outline its potential use as a therapeutic target. Human PDE7 exists as …
21 results