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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 2
1982 4
1983 5
1984 7
1985 11
1986 18
1987 18
1988 27
1989 26
1990 37
1991 29
1992 19
1993 38
1994 30
1995 33
1996 47
1997 16
1998 27
1999 20
2000 23
2001 25
2002 28
2003 35
2004 32
2005 41
2006 44
2007 62
2008 42
2009 59
2010 64
2011 81
2012 62
2013 62
2014 63
2015 73
2016 61
2017 65
2018 53
2019 62
2020 67
2021 62
2022 63
2023 71
2024 25

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1,602 results

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Page 1
Diverse roles of tumor-stromal PDGFB-to-PDGFRbeta signaling in breast cancer growth and metastasis.
Shah S, Sizemore GM. Shah S, et al. Adv Cancer Res. 2022;154:93-140. doi: 10.1016/bs.acr.2022.01.003. Epub 2022 Feb 24. Adv Cancer Res. 2022. PMID: 35459473 Review.
We and others have focused our research efforts on understanding how tumor-derived PDGFB activates platelet-derived growth factor receptor beta (PDGFRbeta) signaling specifically in the breast cancer TME. ...Given the increasingly appreciated importance of PDGFB …
We and others have focused our research efforts on understanding how tumor-derived PDGFB activates platelet-derived growth factor rec …
Cancer Cell-Derived PDGFB Stimulates mTORC1 Activation in Renal Carcinoma.
Abuhamad AY, Mohamad Zamberi NN, Vanharanta S, Mohd Yusuf SNH, Mohtar MA, Syafruddin SE. Abuhamad AY, et al. Int J Mol Sci. 2023 Mar 29;24(7):6447. doi: 10.3390/ijms24076447. Int J Mol Sci. 2023. PMID: 37047421 Free PMC article.
We found that ccRCC cells secreted PDGFB extracellularly, and by utilizing KLF6- and PDGFB-engineered ccRCC cells, we showed that the level of PDGFB secretion was positively correlated with the expression of intracellular KLF6 and PDGFB. ...In conclusi …
We found that ccRCC cells secreted PDGFB extracellularly, and by utilizing KLF6- and PDGFB-engineered ccRCC cells, we showed t …
Anoikis resistant gastric cancer cells promote angiogenesis and peritoneal metastasis through C/EBPbeta-mediated PDGFB autocrine and paracrine signaling.
Du S, Yang Z, Lu X, Yousuf S, Zhao M, Li W, Miao J, Wang X, Yu H, Zhu X, Chen H, Shi L, Xu E, Xia X, Guan W. Du S, et al. Oncogene. 2021 Sep;40(38):5764-5779. doi: 10.1038/s41388-021-01988-y. Epub 2021 Aug 2. Oncogene. 2021. PMID: 34341514
Anoikis resistance (AR) is crucial for the survival of metastatic cancer cells in blood, lymphatic circulation and distant organs. Compared to ordinary cancer cells, anoikis resistant cancer cells undergo various cellular and molecular alterations, probably c …
Anoikis resistance (AR) is crucial for the survival of metastatic cancer cells in blood, lymphatic circulation and distant organs. Co …
Intratumoral PDGFB gene predominantly expressed in endothelial cells is associated with angiogenesis and lymphangiogenesis, but not with metastasis in breast cancer.
Wu R, Gandhi S, Tokumaru Y, Asaoka M, Oshi M, Yan L, Ishikawa T, Takabe K. Wu R, et al. Breast Cancer Res Treat. 2022 Aug;195(1):17-31. doi: 10.1007/s10549-022-06661-w. Epub 2022 Jul 6. Breast Cancer Res Treat. 2022. PMID: 35793004
However, whether these findings could be translated to breast cancer patients remains unclear. We hypothesized that PDGFB gene expression is associated with angiogenesis, cell proliferation, and clinical outcomes in breast cancer patients. ...High PDGFB …
However, whether these findings could be translated to breast cancer patients remains unclear. We hypothesized that PDGFB gene …
Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas.
Weishaupt H, Čančer M, Rosén G, Holmberg KO, Häggqvist S, Bunikis I, Jiang Y, Sreedharan S, Gyllensten U, Becher OJ, Uhrbom L, Ameur A, Swartling FJ. Weishaupt H, et al. Neuro Oncol. 2023 Jan 5;25(1):97-107. doi: 10.1093/neuonc/noac158. Neuro Oncol. 2023. PMID: 35738865 Free PMC article.
Utilizing next-generation sequencing, we show that retroviral integration sites can be reproducibly detected in malignant stem cell lines generated from RCAS-PDGFB-driven glioma biopsies. RESULTS: A large fraction of common integration sites contained genes that hav …
Utilizing next-generation sequencing, we show that retroviral integration sites can be reproducibly detected in malignant stem cell lines ge …
PDGFB targeting biodegradable FePt alloy assembly for MRI guided starvation-enhancing chemodynamic therapy of cancer.
Zhang C, Leng Z, Wang Y, Ran L, Qin X, Xin H, Xu X, Zhang G, Xu Z. Zhang C, et al. J Nanobiotechnology. 2022 Jun 7;20(1):264. doi: 10.1186/s12951-022-01482-x. J Nanobiotechnology. 2022. PMID: 35672821 Free PMC article.
The application of chemodynamic therapy (CDT) for cancer is a serious challenge owing to the low efficiency of the Fenton catalyst and insufficient H(2)O(2) expression in cells. Herein, we fabricated a PDGFB targeting, biodegradable FePt alloy assembly for magnetic …
The application of chemodynamic therapy (CDT) for cancer is a serious challenge owing to the low efficiency of the Fenton catalyst an …
Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma.
Chen Z, Soni N, Pinero G, Giotti B, Eddins DJ, Lindblad KE, Ross JL, Puigdelloses Vallcorba M, Joshi T, Angione A, Thomason W, Keane A, Tsankova NM, Gutmann DH, Lira SA, Lujambio A, Ghosn EEB, Tsankov AM, Hambardzumyan D. Chen Z, et al. Nat Commun. 2023 Apr 3;14(1):1839. doi: 10.1038/s41467-023-37361-8. Nat Commun. 2023. PMID: 37012245 Free PMC article.
Single-cell RNA sequencing reveals that intratumoral neutrophils promote proneural-to-mesenchymal transition and increase hypoxia in PDGFB-driven GBM. We further demonstrate neutrophil-derived TNF-a directly drives mesenchymal transition in PDGFB-driven primary GBM …
Single-cell RNA sequencing reveals that intratumoral neutrophils promote proneural-to-mesenchymal transition and increase hypoxia in PDGF …
PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma-secretase inhibitor.
Pazos MC, Sequeira G, Bocchicchio S, May M, Abramovich D, Parborell F, Tesone M, Irusta G. Pazos MC, et al. J Cell Physiol. 2018 Aug;233(8):5949-5961. doi: 10.1002/jcp.26404. Epub 2018 Feb 27. J Cell Physiol. 2018. PMID: 29266203
Ovarian cancer is the fifth leading cause of cancer-related deaths in women. ...Thus, the aim of the present study was to investigate the effect of a gamma-secretase inhibitor (DAPT) in combination with the Platelet-derived growth factor B (PDGFB) on an ovari …
Ovarian cancer is the fifth leading cause of cancer-related deaths in women. ...Thus, the aim of the present study was to inve …
PDGFB RNA in situ hybridization for the diagnosis of dermatofibrosarcoma protuberans.
Cloutier JM, Allard G, Bean GR, Hornick JL, Charville GW. Cloutier JM, et al. Mod Pathol. 2021 Aug;34(8):1521-1529. doi: 10.1038/s41379-021-00800-2. Epub 2021 Mar 24. Mod Pathol. 2021. PMID: 33762682 Free PMC article.
The vast majority of DFSPs harbor the t(17;22) translocation resulting in a COL1A1-PDGFB fusion that drives autocrine growth stimulation via PDGFB overexpression. ...Vascular PDGFB expression was seen in several tumor types. We conclude that PDGFB RNA …
The vast majority of DFSPs harbor the t(17;22) translocation resulting in a COL1A1-PDGFB fusion that drives autocrine growth stimulat …
[Dermatofibrosarcoma: Management].
Penel N, El Bedoui S, Robin YM, Decanter G. Penel N, et al. Bull Cancer. 2018 Nov;105(11):1094-1101. doi: 10.1016/j.bulcan.2018.08.008. Epub 2018 Oct 5. Bull Cancer. 2018. PMID: 30297237 Review. French.
The histological diagnosis is challenging but we now know a specific marker (translocation t(17;22)(q22;q13) (COL1A1;PDGFB)). The risk of metastatic relapse is low (and related to fibrosarcoma component); the risk of local relapse depends on the quality of surgery. ...Adva …
The histological diagnosis is challenging but we now know a specific marker (translocation t(17;22)(q22;q13) (COL1A1;PDGFB)). The ris …
1,602 results