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miR-365a-5p suppresses gefitinib resistance in non-small-cell lung cancer through targeting PELI3.
Li F, Li H, Li S, Lv B, Shi J, Yan H, Zhang H, He Y. Li F, et al. Pharmacogenomics. 2020 Jul;21(11):771-783. doi: 10.2217/pgs-2020-0006. Epub 2020 Jul 8. Pharmacogenomics. 2020. PMID: 32635799
Aim: Demonstrate the function of dysregulated miR-365a-5p-PELI3 signaling axis in the generation of gefitinib resistance during treatment for non-small-cell lung cancer (NSCLC). ...Tumor growth was suppressed through miR-365a-5p in nude mice. Conclusion: Dysregulate …
Aim: Demonstrate the function of dysregulated miR-365a-5p-PELI3 signaling axis in the generation of gefitinib resistance during treat …
PELI3 mediates pro-tumor actions of down-regulated miR-365a-5p in non-small cell lung cancer.
He Y, Shi Y, Liu R, Wang Z, Wang B, Li S, Zhang H. He Y, et al. Biol Res. 2019 Apr 17;52(1):24. doi: 10.1186/s40659-019-0230-y. Biol Res. 2019. PMID: 30995936 Free PMC article.
BACKGROUND: To analyze the relative expression of PELI3 and its mechanistic involvement in the non-small cell lung cancer (NSCLC). ...High level of PELI3 associated with poor prognosis. PELI3-deficiency significantly inhibited cell viability, colony fo …
BACKGROUND: To analyze the relative expression of PELI3 and its mechanistic involvement in the non-small cell lung cancer (NSC …
Pellino 3 promotes the colitis-associated colorectal cancer through suppression of IRF4-mediated negative regulation of TLR4 signalling.
Kim YM, Kim HY, Ha Thi HT, Kim J, Lee YJ, Kim SJ, Hong S. Kim YM, et al. Mol Oncol. 2023 Nov;17(11):2380-2395. doi: 10.1002/1878-0261.13475. Epub 2023 Jun 27. Mol Oncol. 2023. PMID: 37341064 Free PMC article.
Ablation of Peli3 reduced inflammatory signalling activation at the early stage of carcinogenesis. ...Our study suggests an important molecular link between Peli3 and colonic inflammation-mediated carcinogenesis. Furthermore, Peli3 can be a therapeutic target …
Ablation of Peli3 reduced inflammatory signalling activation at the early stage of carcinogenesis. ...Our study suggests an important …
Long Non-coding RNA MIAT Mediates Non-small Cell Lung Cancer Development Through Regulating the miR-128-3p/PELI3 Axis.
Li F, Li H, Li S, Lv B, Shi J, Yan H, Zhang H, He Y. Li F, et al. Biochem Genet. 2020 Dec;58(6):867-882. doi: 10.1007/s10528-020-09979-6. Epub 2020 Jun 16. Biochem Genet. 2020. PMID: 32556677
We further uncovered the negative correlation among MIAT, PELI3, and miR-128-3p. MIAT deficiency significantly compromised cell viability, proliferation, invasion, and migration, while increased miR-128-3p and decreased PELI3 expressions. ...Our study highlighted th …
We further uncovered the negative correlation among MIAT, PELI3, and miR-128-3p. MIAT deficiency significantly compromised cell viabi …
Role of a novel circulatory RNA-based biomarker panel expression in ovarian cancer.
El-Shal AS, Matboli M, Abdelaziz AM, Morsy AA, Abdelbary EH. El-Shal AS, et al. IUBMB Life. 2019 Dec;71(12):2031-2047. doi: 10.1002/iub.2153. Epub 2019 Sep 13. IUBMB Life. 2019. PMID: 31520466 Free article.
Ovarian cancer (OC) is considered the sixth commonest cancer affecting women globally. We choose novel integrated specific ovarian cancer RNA biomarker panel; pellino E3 ubiquitin protein ligase family member 3 (PELI3) gene expressions along with its s …
Ovarian cancer (OC) is considered the sixth commonest cancer affecting women globally. We choose novel integrated specific ova …
Analysis of high-risk pedigrees identifies 11 candidate variants for Alzheimer's disease.
Teerlink CC, Miller JB, Vance EL, Staley LA, Stevens J, Tavana JP, Cloward ME, Page ML, Dayton L; Alzheimer's Disease Genetics Consortium; Cannon-Albright LA, Kauwe JSK. Teerlink CC, et al. Alzheimers Dement. 2022 Feb;18(2):307-317. doi: 10.1002/alz.12397. Epub 2021 Jun 20. Alzheimers Dement. 2022. PMID: 34151536 Free PMC article.
Eleven variants spanning 10 genes were prioritized in external datasets: rs201665195 (ABCA7), and rs28933981 (TTR) were previously implicated in AD pathology; rs141402160 (NOTCH3) and rs140914494 (NOTCH3) were previously reported; rs200290640 (PIDD1) and rs199752248 (PIDD1) were …
Eleven variants spanning 10 genes were prioritized in external datasets: rs201665195 (ABCA7), and rs28933981 (TTR) were previously implicate …
Genome-wide analysis identifies colonic genes differentially associated with serum leptin and insulin concentrations in C57BL/6J mice fed a high-fat diet.
Kim SE, Choo J, Yoon J, Chu JR, Bae YJ, Lee S, Park T, Sung MK. Kim SE, et al. PLoS One. 2017 Feb 7;12(2):e0171664. doi: 10.1371/journal.pone.0171664. eCollection 2017. PLoS One. 2017. PMID: 28170448 Free PMC article.
Obesity-induced chronic inflammation is known to increase the risk of ulcerative colitis, Crohn's disease, and colorectal cancer. Accumulating evidence suggests that leptin and insulin are key molecules linking obesity with diseases of the lower intestine. ...Our data sugg …
Obesity-induced chronic inflammation is known to increase the risk of ulcerative colitis, Crohn's disease, and colorectal cancer. Acc …