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The following terms were not found in PubMed: 0709700ORprodrug, esteraseANDPlasmodium
Page 1
Identifying Fast and Slow-Acting Antimalarial Compounds of Pandemic Response Box Against Blood-Stage Culture of Plasmodium falciparum 3D7.
Rajendran V, Naveen NC. Rajendran V, et al. Curr Microbiol. 2024 Jan 30;81(3):81. doi: 10.1007/s00284-023-03601-9. Curr Microbiol. 2024. PMID: 38289473
The evolving clinical resistance in Plasmodium falciparum and the spike in malarial cases after the COVID-19 outbreak has triggered a search for new antimalarials effective against multi-drug-resistant P. falciparum strains. In this study, we assessed …
The evolving clinical resistance in Plasmodium falciparum and the spike in malarial cases after the COVID-19 outbreak has trig …
The Multistage Antimalarial Compound Calxinin Perturbates P. falciparum Ca(2+) Homeostasis by Targeting a Unique Ion Channel.
Gupta Y, Sharma N, Singh S, Romero JG, Rajendran V, Mogire RM, Kashif M, Beach J, Jeske W, Poonam, Ogutu BR, Kanzok SM, Akala HM, Legac J, Rosenthal PJ, Rademacher DJ, Durvasula R, Singh AP, Rathi B, Kempaiah P. Gupta Y, et al. Pharmaceutics. 2022 Jun 28;14(7):1371. doi: 10.3390/pharmaceutics14071371. Pharmaceutics. 2022. PMID: 35890267 Free PMC article.
A compound that consists of hydroxyethylamine (HEA) and trifluoromethyl-benzyl-piperazine. Calxinin exhibits potent inhibitory activity in the nanomolar range against the asexual blood stages of drug-sensitive (3D7), multidrug-resistant (Dd2), artemisinin- …
A compound that consists of hydroxyethylamine (HEA) and trifluoromethyl-benzyl-piperazine. Calxinin exhibits potent inhibitory activity …
Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity.
Chouna HSD, Dize D, Kagho DUK, Bankeu JJK, Fongang YSF, Tali MBT, Ponou BK, Bitchagno GTM, Awantu AF, Tapondjou LA, Lenta BN, Fekam FB, Sewald N, Ngouela SA. Chouna HSD, et al. Parasitol Res. 2022 Jul;121(7):2121-2127. doi: 10.1007/s00436-022-07540-5. Epub 2022 May 17. Parasitol Res. 2022. PMID: 35578036 Free PMC article.
Some of the isolated compounds were assessed in vitro for their antiplasmodial activity against Plasmodium falciparum chloroquine-sensitive 3D7 (Pf3D7) and multidrug-resistant Dd2 strains. ...Among the tested compounds, wighteone (2) was the mos …
Some of the isolated compounds were assessed in vitro for their antiplasmodial activity against Plasmodium falciparum chloroqu …
Dinuclear and mononuclear metal(II) polypyridyl complexes against drug-sensitive and drug-resistant Plasmodium falciparum and their mode of action.
Lai JW, Maah MJ, Tan KW, Sarip R, Lim YAL, Ganguly R, Khaw LT, Ng CH. Lai JW, et al. Malar J. 2022 Dec 17;21(1):386. doi: 10.1186/s12936-022-04406-0. Malar J. 2022. PMID: 36528584 Free PMC article.
X-ray crystal structure of the dicopper(II) complex was determined. The in vitro haemolytic activities of these metal complexes were evaluated spectroscopically on B+ blood while the anti-malarial potency was performed in vitro on blood stage drug-sensitive Plasmodium f …
X-ray crystal structure of the dicopper(II) complex was determined. The in vitro haemolytic activities of these metal complexes were …
Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Calic PPS, Vinh NB, Webb CT, Malcolm TR, Ngo A, Lowes K, Drinkwater N, McGowan S, Scammells PJ. Calic PPS, et al. Eur J Med Chem. 2023 Feb 15;248:115051. doi: 10.1016/j.ejmech.2022.115051. Epub 2022 Dec 29. Eur J Med Chem. 2023. PMID: 36634455
The Plasmodium spp M1 and M17 metalloaminopeptidases have been identified as attractive new antimalarial drug targets as inhibition of these enzymes results in antiplasmodial activity. Previously identified novel hydroxamic acid 2 as a moderate inhibitor of PfA-M1 and PfA- …
The Plasmodium spp M1 and M17 metalloaminopeptidases have been identified as attractive new antimalarial drug targets as inhibition of these …
Combined Transcriptome and Proteome Profiling for Role of pfEMP1 in Antimalarial Mechanism of Action of Dihydroartemisinin.
Chen L, Zheng Z, Liu H, Wang X, Qu S, Yang Y, Deng S, Zhang Y, Tuo L, Zhao Y, Li Y. Chen L, et al. Microbiol Spectr. 2021 Dec 22;9(3):e0127821. doi: 10.1128/Spectrum.01278-21. Epub 2021 Dec 15. Microbiol Spectr. 2021. PMID: 34908430 Free PMC article.
However, the mechanism of action of artemisinin is unclear, and drug resistance decreases long-term efficacy. To understand whether artemisinin targets or interacts with iRBC membrane proteins, this study investigated the molecular changes caused by dihydroartemisinin (DHA …
However, the mechanism of action of artemisinin is unclear, and drug resistance decreases long-term efficacy. To understand whether a …
Antiplasmodial and Antileishmanial Activities of a New Limonoid and Other Constituents from the Stem Bark of Khaya senegalensis.
Amang À Ngnoung GA, Nganso Ditchou YO, Leutcha PB, Dize D, Tatsimo SJN, Tchokouaha LRY, Kowa TK, Tembeni B, Mamoudou H, Poka M, Demana PH, Siwe Noundou X, Fekam Boyom F, Meli Lannang A. Amang À Ngnoung GA, et al. Molecules. 2023 Oct 23;28(20):7227. doi: 10.3390/molecules28207227. Molecules. 2023. PMID: 37894704 Free PMC article.
Plasmodium falciparum and Leishmania sp. resistance to antiparasitic drugs has become a major concern in malaria and leishmaniasis control. ...The extracts and compounds were screened using pre-established in vitro methods against synchronized ring stage cultures of …
Plasmodium falciparum and Leishmania sp. resistance to antiparasitic drugs has become a major concern in malaria and leishmani …
Anti-Plasmodium falciparum Activity of Extracts from 10 Cameroonian Medicinal Plants.
Rufin Marie TK, Mbetyoumoun Mfouapon H, Madiesse Kemgne EA, Jiatsa Mbouna CD, Tsouh Fokou PV, Sahal D, Fekam Boyom F. Rufin Marie TK, et al. Medicines (Basel). 2018 Oct 29;5(4):115. doi: 10.3390/medicines5040115. Medicines (Basel). 2018. PMID: 30380685 Free PMC article.
Methods: Extracts were evaluated for their capacity to inhibit the growth of the chloroquine-sensitive (Pf3D7) and resistant (PfINDO) strains of P. falciparum using the SYBR green fluorescence method. ...Six extracts exhibited good activity against bot …
Methods: Extracts were evaluated for their capacity to inhibit the growth of the chloroquine-sensitive (Pf3D7) and resistant ( …
Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children.
Conrad MD, Bigira V, Kapisi J, Muhindo M, Kamya MR, Havlir DV, Dorsey G, Rosenthal PJ. Conrad MD, et al. PLoS One. 2014 Aug 21;9(8):e105690. doi: 10.1371/journal.pone.0105690. eCollection 2014. PLoS One. 2014. PMID: 25144768 Free PMC article. Clinical Trial.
Recently, the artemisinin resistance phenotype was attributed to mutations in portions of a P. falciparum gene (PF3D7_1343700) encoding kelch (K13) propeller domains, providing a molecular marker to monitor the spread of resistance. The P. falciparu …
Recently, the artemisinin resistance phenotype was attributed to mutations in portions of a P. falciparum gene (PF3D7_1 …
Plasmodium falciparum DDX55 is a nucleocytoplasmic protein and a 3'-5' direction-specific DNA helicase.
Yasmin R, Kaur I, Tuteja R. Yasmin R, et al. Protoplasma. 2020 Jul;257(4):1049-1067. doi: 10.1007/s00709-020-01495-z. Epub 2020 Mar 3. Protoplasma. 2020. PMID: 32125511
Here, we present the characterization of a member of Has1 family (PlasmoDB number PF3D7_1419100) named as PfDDX55. The biochemical characterization of PfDDX55C revealed that it contains both DNA- and RNA-dependent ATPase activity. PfDDX55C unwinds partially duplex D …
Here, we present the characterization of a member of Has1 family (PlasmoDB number PF3D7_1419100) named as PfDDX55. The biochemical ch …
22 results