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The following terms were not found in PubMed: 1240000OR3-hydroxyisobutyryl-CoA, putativeANDPlasmodium
Page 1
Identification and characterization of DNA endonucleases in Plasmodium falciparum 3D7 clone.
Jiang N, Tu Z, Zhang Y, Li J, Feng Y, Yang N, Sang X, Chen Q. Jiang N, et al. Malar J. 2018 Jun 18;17(1):232. doi: 10.1186/s12936-018-2388-0. Malar J. 2018. PMID: 29914511 Free PMC article.
But the proteins encoded by PF3D7_0305600 and PF3D7_1363500 were distributed around the infected erythrocyte membrane. ...Further, divalent irons did not show any specific enhancement on the activity of GST-PF3D7_1238600, but the activity of GST-PF3D7_ …
But the proteins encoded by PF3D7_0305600 and PF3D7_1363500 were distributed around the infected erythrocyte membrane. ...Furt …
Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites.
Guggisberg AM, Frasse PM, Jezewski AJ, Kafai NM, Gandhi AY, Erlinger SJ, Odom John AR. Guggisberg AM, et al. mBio. 2018 Nov 13;9(6):e01193-18. doi: 10.1128/mBio.01193-18. mBio. 2018. PMID: 30425143 Free PMC article.
In the malaria parasite Plasmodium falciparum, synthesis of isoprenoids from glycolytic intermediates is essential for survival. The antimalarial fosmidomycin (FSM) inhibits isoprenoid synthesis. In P. falciparum, we identified a loss-of-function mutation in HAD2 (P …
In the malaria parasite Plasmodium falciparum, synthesis of isoprenoids from glycolytic intermediates is essential for survival. The …
Plasmodium falciparum DDX55 is a nucleocytoplasmic protein and a 3'-5' direction-specific DNA helicase.
Yasmin R, Kaur I, Tuteja R. Yasmin R, et al. Protoplasma. 2020 Jul;257(4):1049-1067. doi: 10.1007/s00709-020-01495-z. Epub 2020 Mar 3. Protoplasma. 2020. PMID: 32125511
Previously, it has been reported that P. falciparum contains a group of DEAD-box family of helicases which are homologous to Has1 family of yeast. ...The immunofluorescence assay and q-RT PCR analysis show that PfDDX55 is a nucleocytoplasmic protein expressed in all the in …
Previously, it has been reported that P. falciparum contains a group of DEAD-box family of helicases which are homologous to Has1 fam …
Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children.
Conrad MD, Bigira V, Kapisi J, Muhindo M, Kamya MR, Havlir DV, Dorsey G, Rosenthal PJ. Conrad MD, et al. PLoS One. 2014 Aug 21;9(8):e105690. doi: 10.1371/journal.pone.0105690. eCollection 2014. PLoS One. 2014. PMID: 25144768 Free PMC article. Clinical Trial.
Recently, the artemisinin resistance phenotype was attributed to mutations in portions of a P. falciparum gene (PF3D7_1343700) encoding kelch (K13) propeller domains, providing a molecular marker to monitor the spread of resistance. The P. falciparum cysteine …
Recently, the artemisinin resistance phenotype was attributed to mutations in portions of a P. falciparum gene (PF3D7_1343700) …
Design and Synthesis of Novel Anti-Plasmodial Histone Deacetylase Inhibitors Containing an Alkoxyamide Connecting Unit.
Alves Avelar LA, Held J, Engel JA, Sureechatchaiyan P, Hansen FK, Hamacher A, Kassack MU, Mordmüller B, Andrews KT, Kurz T. Alves Avelar LA, et al. Arch Pharm (Weinheim). 2017 Apr;350(3-4). doi: 10.1002/ardp.201600347. Epub 2017 Mar 20. Arch Pharm (Weinheim). 2017. PMID: 28317157
Using a 5-step synthetic route, 12 new inhibitors were synthesized and assayed against Plasmodium falciparum asexual blood stage parasites (clones 3D7 and Dd2) and human cells (HepG2). ...Selected compounds were shown to cause hyperacetylation of P. falciparum …
Using a 5-step synthetic route, 12 new inhibitors were synthesized and assayed against Plasmodium falciparum asexual blood stage para …
Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Calic PPS, Vinh NB, Webb CT, Malcolm TR, Ngo A, Lowes K, Drinkwater N, McGowan S, Scammells PJ. Calic PPS, et al. Eur J Med Chem. 2023 Feb 15;248:115051. doi: 10.1016/j.ejmech.2022.115051. Epub 2022 Dec 29. Eur J Med Chem. 2023. PMID: 36634455
Previously identified novel hydroxamic acid 2 as a moderate inhibitor of PfA-M1 and PfA-M17 and a potent inhibitor of P. falciparum. This study has sought to improve the enzymatic inhibitory properties in addition to increasing the drug-likeness of this scaffold by introdu …
Previously identified novel hydroxamic acid 2 as a moderate inhibitor of PfA-M1 and PfA-M17 and a potent inhibitor of P. falciparum. …