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Year Number of Results
2002 1
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2006 1
2011 1
2013 3
2014 2
2015 5
2016 5
2017 5
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2020 21
2021 23
2022 18
2023 29
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144 results

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Page 1
PFKP phenotype in lung cancer: prognostic potential and beyond.
Ganapathy-Kanniappan S. Ganapathy-Kanniappan S. Mol Biol Rep. 2020 Oct;47(10):8271-8272. doi: 10.1007/s11033-020-05805-9. Epub 2020 Sep 11. Mol Biol Rep. 2020. PMID: 32915402 Review.
In a recent report of Cellular Oncology, Shen et al., have investigated one of the forms of PFK known as the platelet-type PFK (PFKP) in lung cancer. Using clinical samples as well as experimental models the authors unravel the cancer-related roles of PFKP …
In a recent report of Cellular Oncology, Shen et al., have investigated one of the forms of PFK known as the platelet-type PFK (PFKP) …
PFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation.
Chen J, Zou L, Lu G, Grinchuk O, Fang L, Ong DST, Taneja R, Ong CN, Shen HM. Chen J, et al. Cell Discov. 2022 May 31;8(1):52. doi: 10.1038/s41421-022-00406-1. Cell Discov. 2022. PMID: 35641476 Free PMC article.
However, the underlying mechanism of AMPK in handling metabolic stress in cancer remains to be fully understood. In this study, by performing a proteomics screening of AMPK-interacting proteins in non-small-cell lung cancer (NSCLC) cells, we discovered the platelet …
However, the underlying mechanism of AMPK in handling metabolic stress in cancer remains to be fully understood. In this study, by pe …
PFKP: More than phosphofructokinase.
Wang H, Penaloza T, Manea AJ, Gao X. Wang H, et al. Adv Cancer Res. 2023;160:1-15. doi: 10.1016/bs.acr.2023.03.001. Epub 2023 Mar 30. Adv Cancer Res. 2023. PMID: 37704285 Review.
The functions of PFKP are extensively studied in cancer cells. PFKP is also highly expressed in certain immune cells; nevertheless, the study of the PFKP's role in immune cells is limited. In this review, we summarize how the expression and activity of …
The functions of PFKP are extensively studied in cancer cells. PFKP is also highly expressed in certain immune cells; n …
PFKP Signaling at a Glance: An Emerging Mediator of Cancer Cell Metabolism.
Lang L, Chemmalakuzhy R, Shay C, Teng Y. Lang L, et al. Adv Exp Med Biol. 2019;1134:243-258. doi: 10.1007/978-3-030-12668-1_13. Adv Exp Med Biol. 2019. PMID: 30919341 Review.
Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant tumors. The possible use of PFKP as a d …
Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and …
SOX2 mediates metabolic reprogramming of prostate cancer cells.
de Wet L, Williams A, Gillard M, Kregel S, Lamperis S, Gutgesell LC, Vellky JE, Brown R, Conger K, Paner GP, Wang H, Platz EA, De Marzo AM, Mu P, Coloff JL, Szmulewitz RZ, Vander Griend DJ. de Wet L, et al. Oncogene. 2022 Feb;41(8):1190-1202. doi: 10.1038/s41388-021-02157-x. Epub 2022 Jan 24. Oncogene. 2022. PMID: 35067686 Free PMC article.
New strategies are needed to predict and overcome metastatic progression and therapy resistance in prostate cancer. One potential clinical target is the stem cell transcription factor SOX2, which has a critical role in prostate development and cancer. ...Interesting …
New strategies are needed to predict and overcome metastatic progression and therapy resistance in prostate cancer. One potential cli …
PFKP is highly expressed in lung cancer and regulates glucose metabolism.
Shen J, Jin Z, Lv H, Jin K, Jonas K, Zhu C, Chen B. Shen J, et al. Cell Oncol (Dordr). 2020 Aug;43(4):617-629. doi: 10.1007/s13402-020-00508-6. Epub 2020 Mar 26. Cell Oncol (Dordr). 2020. PMID: 32219704
The objective of this study was to evaluate PFKP expression in lung cancer and its effect on glycolysis, and to explore correlations between PFKP expression levels and clinical lung cancer patient features. ...As such, PFKP may serve as a progno …
The objective of this study was to evaluate PFKP expression in lung cancer and its effect on glycolysis, and to explore correl …
PFKP is a prospective prognostic, diagnostic, immunological and drug sensitivity predictor across pan-cancer.
Peng J, Li P, Li Y, Quan J, Yao Y, Duan J, Liu X, Li H, Yuan D, Wang X. Peng J, et al. Sci Rep. 2023 Oct 13;13(1):17399. doi: 10.1038/s41598-023-43982-2. Sci Rep. 2023. PMID: 37833332 Free PMC article.
PFKP has been reported to have multiple functions in different cancer types, including lung cancer and breast cancer. ...Our analysis revealed that high expression of PFKP was found in most cancer types. Additionally, a high level of P …
PFKP has been reported to have multiple functions in different cancer types, including lung cancer and breast cancer …
Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer.
Jiang H, Wei H, Wang H, Wang Z, Li J, Ou Y, Xiao X, Wang W, Chang A, Sun W, Zhao L, Yang S. Jiang H, et al. Cell Death Dis. 2022 Mar 4;13(3):206. doi: 10.1038/s41419-022-04632-z. Cell Death Dis. 2022. PMID: 35246504 Free PMC article.
Here, we show that ectopic Zeb1 directly increases the transcriptional expression of HK2, PFKP, and PKM2, which are glycolytic rate-determining enzymes, thus promoting the Warburg effect and breast cancer proliferation, migration, and chemoresistance in vitro and in …
Here, we show that ectopic Zeb1 directly increases the transcriptional expression of HK2, PFKP, and PKM2, which are glycolytic rate-d …
PFKP confers chemoresistance by upregulating ABCC2 transporter in non-small cell lung cancer.
Wang Z, Wu S, Chen X, Liang J, Xue F, Cho WC, Bao J, Chen B, Ye M, Ma D, Zhu C, Zhu J, Shen J. Wang Z, et al. Transl Lung Cancer Res. 2023 Nov 30;12(11):2294-2309. doi: 10.21037/tlcr-23-567. Epub 2023 Nov 24. Transl Lung Cancer Res. 2023. PMID: 38090515 Free PMC article.
BACKGROUND: Chemoresistance is a significant factor contributing to tumor recurrence and treatment failure in non-small cell lung cancer (NSCLC). The phosphofructokinase, platelet (PFKP) is highly expressed in NSCLC and is associated with a poor prognosis. ...The im …
BACKGROUND: Chemoresistance is a significant factor contributing to tumor recurrence and treatment failure in non-small cell lung cancer …
p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP.
Huang Y, Xiong C, Wang C, Deng J, Zuo Z, Wu H, Xiong J, Wu X, Lu H, Hao Q, Zhou X. Huang Y, et al. Cell Rep. 2023 Nov 28;42(11):113426. doi: 10.1016/j.celrep.2023.113426. Epub 2023 Nov 16. Cell Rep. 2023. PMID: 37967006 Free article.
The anti-cancer action of CMBL is mediated through its interactions with the E3 ubiquitin ligase TRIM25 and the glycolytic enzyme phosphofructokinase-1 platelet type (PFKP). Ectopic CMBL enhances TRIM25 binding to PFKP, leading to the ubiquitination and prote …
The anti-cancer action of CMBL is mediated through its interactions with the E3 ubiquitin ligase TRIM25 and the glycolytic enzyme pho …
144 results