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1996 1
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2010 3
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2014 7
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72 results

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LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM.
Zhang F, Wang H, Yu J, Yao X, Yang S, Li W, Xu L, Zhao L. Zhang F, et al. Mol Cancer. 2021 Jan 4;20(1):6. doi: 10.1186/s12943-020-01299-y. Mol Cancer. 2021. PMID: 33397371 Free PMC article.
De novo and acquired resistance, which are mainly mediated by genetic alterations, are barriers to effective routine chemotherapy. However, the mechanisms underlying gastric cancer (GC) resistance to chemotherapy are still unclear. We showed that the long noncoding RNA CRN …
De novo and acquired resistance, which are mainly mediated by genetic alterations, are barriers to effective routine chemotherapy. However, …
PICALM as a Novel Prognostic Biomarker and Its Correlation with Immune Infiltration in Breast Cancer.
A N, Lyu P, Yu Y, Liu M, Cheng S, Chen M, Liu Y, Cao X. A N, et al. Appl Biochem Biotechnol. 2024 Jan 4. doi: 10.1007/s12010-023-04840-z. Online ahead of print. Appl Biochem Biotechnol. 2024. PMID: 38175412
Nevertheless, the effect of PICALM on cancer, particularly on prognosis and immune infiltration in individuals with BRCA, is unknown. We obtained the data of breast cancer patients from The Cancer Genome Atlas (TCGA) database, and analyzed the expressi …
Nevertheless, the effect of PICALM on cancer, particularly on prognosis and immune infiltration in individuals with BRCA, is u …
Treatment outcomes of childhood PICALM::MLLT10 acute leukaemias.
Mark C, Meshinchi S, Joyce B, Gibson B, Harrison C, Bergmann AK, Goemans BF, Pronk CJH, Lapillonne H, Leverger G, Antoniou E, Schneider M, Attarbaschi A, Dworzak M, Stary J, Tomizawa D, Ebert S, Lejman M, Kolb EA, Schmiegelow K, Hasle H, Abla O. Mark C, et al. Br J Haematol. 2024 Feb;204(2):576-584. doi: 10.1111/bjh.19067. Epub 2023 Sep 24. Br J Haematol. 2024. PMID: 37743097
The prognostic impact of PICALM::MLLT10 status in childhood leukaemia is not well described. ...Most patients received a chemotherapy regimen per their disease phenotype: 58% received an ALL regimen, 40% an AML regimen and 1% a hybrid regimen. Outcomes for children with …
The prognostic impact of PICALM::MLLT10 status in childhood leukaemia is not well described. ...Most patients received a chemotherapy …
PICALM exerts a role in promoting CRC progression through ERK/MAPK signaling pathway.
Zhang X, Liu T, Huang J, He J. Zhang X, et al. Cancer Cell Int. 2022 May 2;22(1):178. doi: 10.1186/s12935-022-02577-z. Cancer Cell Int. 2022. PMID: 35501863 Free PMC article.
In this study, the functions and potential mechanism of phosphatidylinositol-binding clathrin assembly protein (PICALM) in CRC were preliminarily explored. METHODS: Based on the Cancer Genome Atlas database and immunohistochemistry staining, revealing that the expre …
In this study, the functions and potential mechanism of phosphatidylinositol-binding clathrin assembly protein (PICALM) in CRC were p …
Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis.
Mercer JL, Argus JP, Crabtree DM, Keenan MM, Wilks MQ, Chi JT, Bensinger SJ, Lavau CP, Wechsler DS. Mercer JL, et al. PLoS One. 2015 Jun 15;10(6):e0129776. doi: 10.1371/journal.pone.0129776. eCollection 2015. PLoS One. 2015. PMID: 26075887 Free PMC article.
To obtain insight into the biological role of PICALM, we performed gene expression studies of PICALM-deficient and PICALM-expressing cells. ...These findings suggest that PICALM is required for cellular cholesterol homeostasis and point to a novel mech …
To obtain insight into the biological role of PICALM, we performed gene expression studies of PICALM-deficient and PICALM …
PICALM modulates autophagy activity and tau accumulation.
Moreau K, Fleming A, Imarisio S, Lopez Ramirez A, Mercer JL, Jimenez-Sanchez M, Bento CF, Puri C, Zavodszky E, Siddiqi F, Lavau CP, Betton M, O'Kane CJ, Wechsler DS, Rubinsztein DC. Moreau K, et al. Nat Commun. 2014 Sep 22;5:4998. doi: 10.1038/ncomms5998. Nat Commun. 2014. PMID: 25241929 Free PMC article.
Genome-wide association studies have identified several loci associated with Alzheimer's disease (AD), including proteins involved in endocytic trafficking such as PICALM/CALM (phosphatidylinositol binding clathrin assembly protein). ...
Genome-wide association studies have identified several loci associated with Alzheimer's disease (AD), including proteins involved in endocy …
Genomic and global gene expression profiling in pediatric and young adult acute leukemia with PICALM::MLLT10 Fusion.
Ma J, Liu YC, Voss RK, Ma J, Palagani A, Caldwell E, Rosikiewicz W, Cardenas M, Foy S, Umeda M, Wilkinson MR, Inaba H, Klco JM, Rubnitz JE, Wang L. Ma J, et al. Leukemia. 2024 May;38(5):981-990. doi: 10.1038/s41375-024-02194-x. Epub 2024 Mar 1. Leukemia. 2024. PMID: 38429501
Our study also suggested PHF6 disruption as a key cooperating event in PICALM::MLLT10-positive leukemias. In addition, we demonstrated differences in gene expression profiles as well as remarkably different spectra of co-occurring mutations between PM-AML and PM-T-ALL/LLy. …
Our study also suggested PHF6 disruption as a key cooperating event in PICALM::MLLT10-positive leukemias. In addition, we demonstrate …
Functional insight into LOAD-associated microglial response genes.
Jonas LA, Jain T, Li YM. Jonas LA, et al. Open Biol. 2022 Jan;12(1):210280. doi: 10.1098/rsob.210280. Epub 2022 Jan 26. Open Biol. 2022. PMID: 35078351 Free PMC article. Review.
Moreover, numerous variants in immune and/or microglia-related genes have been identified in whole-genome sequencing and GWAS analyses, including such genes as TREM2, CD33, APOE, API1, MS4A, ABCA7, BIN1, CLU, CR1, INPP5D, PICALM and PLCG2. In this review, we aim to provide …
Moreover, numerous variants in immune and/or microglia-related genes have been identified in whole-genome sequencing and GWAS analyses, incl …
PICALM-MLLT10 acute myeloid leukemia: a French cohort of 18 patients.
Borel C, Dastugue N, Cances-Lauwers V, Mozziconacci MJ, Prebet T, Vey N, Pigneux A, Lippert E, Visanica S, Legrand F, Rault JP, Taviaux S, Bastard C, Mugneret F, Collonges Rames MA, Gachard N, Talmant P, Delabesse E, Récher C. Borel C, et al. Leuk Res. 2012 Nov;36(11):1365-9. doi: 10.1016/j.leukres.2012.07.008. Epub 2012 Aug 5. Leuk Res. 2012. PMID: 22871473
In this study, we assessed the characteristics and outcome of 18 PICALM-MLLT10 AML patients. As compared with non PICALM-MLLT10 patients (n=72), PICALM-MLLT10 AML were characterized by more frequent extramedullary diseases, CD7 expression and higher platelet …
In this study, we assessed the characteristics and outcome of 18 PICALM-MLLT10 AML patients. As compared with non PICALM-MLLT1 …
Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.
Ishikawa Y, Maeda M, Pasham M, Aguet F, Tacheva-Grigorova SK, Masuda T, Yi H, Lee SU, Xu J, Teruya-Feldstein J, Ericsson M, Mullally A, Heuser J, Kirchhausen T, Maeda T. Ishikawa Y, et al. Haematologica. 2015 Apr;100(4):439-51. doi: 10.3324/haematol.2014.119537. Epub 2014 Dec 31. Haematologica. 2015. PMID: 25552701 Free PMC article.
Here we show, by employing a series of conditional Picalm knockout mice, that PICALM critically regulates transferrin uptake in erythroid cells by functioning as a cell-type-specific regulator of transferrin receptor endocytosis. While transferrin receptor is essent …
Here we show, by employing a series of conditional Picalm knockout mice, that PICALM critically regulates transferrin uptake i …
72 results