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Page 1
Mechano-Sensing Channel PIEZO2 Enhances Invasive Phenotype in Triple-Negative Breast Cancer.
Katsuta E, Takabe K, Vujcic M, Gottlieb PA, Dai T, Mercado-Perez A, Beyder A, Wang Q, Opyrchal M. Katsuta E, et al. Int J Mol Sci. 2022 Aug 31;23(17):9909. doi: 10.3390/ijms23179909. Int J Mol Sci. 2022. PMID: 36077309 Free PMC article.
BACKGROUND: Mechanically gated PIEZO channels lead to an influx of cations, activation of additional Ca(2+) channels, and cell depolarization. This study aimed to investigate PIEZO2's role in breast cancer. METHODS: The clinical relevance of PIEZO2 expression …
BACKGROUND: Mechanically gated PIEZO channels lead to an influx of cations, activation of additional Ca(2+) channels, and cell depolarizatio …
Expression and Clinical Significance of PIEZO2 in Gastric Cancer.
Liang T, Da MX. Liang T, et al. Comb Chem High Throughput Screen. 2023;26(12):2194-2200. doi: 10.2174/1386207326666230209140929. Comb Chem High Throughput Screen. 2023. PMID: 36757044
OBJECTIVE: The aim of this research was to investigate the expression of PIEZO2 and its potential clinical significance in gastric cancer (GC). ...Aberrant overexpression of PIEZO2 was associated with poor prognosis of GC patients. Proteins such as VR1, TRPV1 …
OBJECTIVE: The aim of this research was to investigate the expression of PIEZO2 and its potential clinical significance in gastric …
A pan-cancer analysis reveals the genetic alterations and immunotherapy of Piezo2 in human cancer.
Liu X, Jia Y, Wang Z, Zhang Z, Fu W. Liu X, et al. Front Genet. 2022 Aug 4;13:918977. doi: 10.3389/fgene.2022.918977. eCollection 2022. Front Genet. 2022. PMID: 35991548 Free PMC article.
The prognostic and immunotherapeutic roles of Piezo2 in pan-cancer have not been reported. Methods: In this study, several databases available including the UCSC Xena database, HPA, TIDE, GSEA, and cBioportal were used to investigate the expression, alterations, ass …
The prognostic and immunotherapeutic roles of Piezo2 in pan-cancer have not been reported. Methods: In this study, several dat …
Potentiation of PIEZO2 mechanically-activated currents in sensory neurons mediates vincristine-induced mechanical hypersensitivity.
Duan M, Jia Y, Huo L, Gao Y, Wang J, Zhang W, Jia Z. Duan M, et al. Acta Pharm Sin B. 2023 Aug;13(8):3365-3381. doi: 10.1016/j.apsb.2023.05.010. Epub 2023 May 15. Acta Pharm Sin B. 2023. PMID: 37655331 Free PMC article.
In the present study, we show with behavioral assessment in rats that vincristine induces mechanical allodynia and hyperalgesia in a PIEZO2 channel-dependent manner since gene knockdown or pharmacological inhibition of PIEZO2 channels alleviates vincristine-induced …
In the present study, we show with behavioral assessment in rats that vincristine induces mechanical allodynia and hyperalgesia in a PIEZ …
Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity.
Chen X, Momin A, Wanggou S, Wang X, Min HK, Dou W, Gong Z, Chan J, Dong W, Fan JJ, Xiong Y, Talipova K, Zhao H, Chen YX, Veerasammy K, Fekete A, Kumar SA, Liu H, Yang Q, Son JE, Dou Z, Hu M, Pardis P, Juraschka K, Donovan LK, Zhang J, Ramaswamy V, Selvadurai HJ, Dirks PB, Taylor MD, Wang LY, Hui CC, Abzalimov R, He Y, Sun Y, Li X, Huang X. Chen X, et al. Neuron. 2023 Jan 4;111(1):30-48.e14. doi: 10.1016/j.neuron.2022.10.007. Epub 2022 Nov 1. Neuron. 2023. PMID: 36323321 Free article.
Major obstacles in brain cancer treatment include the blood-tumor barrier (BTB), which limits the access of most therapeutic agents, and quiescent tumor cells, which resist conventional chemotherapy. ...Our study reveals that mechanosensitive tumor cells construct the BTB …
Major obstacles in brain cancer treatment include the blood-tumor barrier (BTB), which limits the access of most therapeutic agents, …
PIEZO2 expression is an independent biomarker prognostic for gastric cancer and represents a potential therapeutic target.
Zhang YC, Yang M, Lu CD, Li QY, Shi JN, Shi J. Zhang YC, et al. Sci Rep. 2024 Jan 12;14(1):1206. doi: 10.1038/s41598-023-48577-5. Sci Rep. 2024. PMID: 38216574 Free PMC article.
The effect of PIEZO2 on the immune function and pathological features of gastric cancer remains to be explored. The Online database of cancer genes and GSE54129 have been used to analyze the clinical characteristics of PIEZO2 expression. ...
The effect of PIEZO2 on the immune function and pathological features of gastric cancer remains to be explored. The Online dat …
Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity.
García-Mesa Y, Martín-Sanz R, García-Piqueras J, Cobo R, Muñoz-Bravo S, García-Suárez O, Martín-Biedma B, Vega JA, Feito J. García-Mesa Y, et al. J Pers Med. 2022 May 28;12(6):894. doi: 10.3390/jpm12060894. J Pers Med. 2022. PMID: 35743679 Free PMC article.
A panel of antibodies was used to characterize Merkel cells, and to detect PIEZO2 expression. All analyzed tumors displayed PIEZO2 in nearly all cells, showing two patterns of immunostaining: membranous and perinuclear dot-like. PIEZO2 co-localized with cytok …
A panel of antibodies was used to characterize Merkel cells, and to detect PIEZO2 expression. All analyzed tumors displayed PIEZO2 …
Five miRNAs-mediated PIEZO2 downregulation, accompanied with activation of Hedgehog signaling pathway, predicts poor prognosis of breast cancer.
Lou W, Liu J, Ding B, Jin L, Xu L, Li X, Chen J, Fan W. Lou W, et al. Aging (Albany NY). 2019 May 6;11(9):2628-2652. doi: 10.18632/aging.101934. Aging (Albany NY). 2019. PMID: 31058608 Free PMC article.
Roles of Piezo-type mechanosensitive ion channel component 2 (PIEZO2) in cancer remain largely unknown. Herein, we explored PIEZO2 expression, prognosis and underlying mechanisms in cancer. ...Subsequent analysis revealed that high expression of PIE …
Roles of Piezo-type mechanosensitive ion channel component 2 (PIEZO2) in cancer remain largely unknown. Herein, we explored …
Varying mechanical forces drive sensory epithelium formation.
Xia M, Wu M, Li Y, Liu Y, Jia G, Lou Y, Ma J, Gao Q, Xie M, Chen Y, He Y, Li H, Li W. Xia M, et al. Sci Adv. 2023 Nov 3;9(44):eadf2664. doi: 10.1126/sciadv.adf2664. Epub 2023 Nov 3. Sci Adv. 2023. PMID: 37922362 Free PMC article.
Higher stiffness induced the transition of CPCs into sensory hair cells (HCs) through increasing the intracellular Ca(2+) signaling mediated by PIEZO2 and then activating KLF2 to accomplish the cell specification . ...
Higher stiffness induced the transition of CPCs into sensory hair cells (HCs) through increasing the intracellular Ca(2+) signaling mediated …
PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.
Shang H, Xu A, Yan H, Xu D, Zhang J, Fang X. Shang H, et al. Adv Clin Exp Med. 2023 Jul;32(7):763-776. doi: 10.17219/acem/157515. Adv Clin Exp Med. 2023. PMID: 36753373 Free article.
OBJECTIVES: To explore the potential mechanism and effect of PIEZO2 on colon cancer. MATERIAL AND METHODS: We assessed the expression and prognostic role of PIEZO2 in patients with colon cancer. ...The expression of PIEZO2 was higher in cance …
OBJECTIVES: To explore the potential mechanism and effect of PIEZO2 on colon cancer. MATERIAL AND METHODS: We assessed the exp …
36 results