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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2004 2
2007 1
2008 1
2009 1
2011 4
2012 3
2013 2
2014 3
2015 10
2016 14
2017 4
2018 3
2019 11
2020 11
2021 15
2022 17
2023 13
2024 6

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107 results

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Page 1
Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors.
Liu Y, Wang D, Li Z, Li X, Jin M, Jia N, Cui X, Hu G, Tang T, Yu Q. Liu Y, et al. Sci Rep. 2022 Apr 8;12(1):5924. doi: 10.1038/s41598-022-09889-0. Sci Rep. 2022. PMID: 35395865 Free PMC article.
Our study conducted a comparatively comprehensive analysis of the role of PIK3R1 and PIK3R2 in a variety of cancers, contributing to further study of their potential mechanisms in cancer occurrence and progression. Our findings suggested that PIK3R1 and PI …
Our study conducted a comparatively comprehensive analysis of the role of PIK3R1 and PIK3R2 in a variety of cancers, contribut …
The Opposing Roles of PIK3R1/p85alpha and PIK3R2/p85beta in Cancer.
Vallejo-Díaz J, Chagoyen M, Olazabal-Morán M, González-García A, Carrera AC. Vallejo-Díaz J, et al. Trends Cancer. 2019 Apr;5(4):233-244. doi: 10.1016/j.trecan.2019.02.009. Epub 2019 Mar 16. Trends Cancer. 2019. PMID: 30961830 Review.
PIK3R1 is the predominant regulatory isoform of PI3K. PIK3R2 is an ubiquitous isoform that has been so far overlooked, but data from The Cancer Genome Atlas shows that increased expression of PIK3R2 is also frequent in cancer. In contrast to PIK3R1, wh …
PIK3R1 is the predominant regulatory isoform of PI3K. PIK3R2 is an ubiquitous isoform that has been so far overlooked, but data from …
De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes.
Rivière JB, Mirzaa GM, O'Roak BJ, Beddaoui M, Alcantara D, Conway RL, St-Onge J, Schwartzentruber JA, Gripp KW, Nikkel SM, Worthylake T, Sullivan CT, Ward TR, Butler HE, Kramer NA, Albrecht B, Armour CM, Armstrong L, Caluseriu O, Cytrynbaum C, Drolet BA, Innes AM, Lauzon JL, Lin AE, Mancini GM, Meschino WS, Reggin JD, Saggar AK, Lerman-Sagie T, Uyanik G, Weksberg R, Zirn B, Beaulieu CL; Finding of Rare Disease Genes (FORGE) Canada Consortium; Majewski J, Bulman DE, O'Driscoll M, Shendure J, Graham JM Jr, Boycott KM, Dobyns WB. Rivière JB, et al. Nat Genet. 2012 Jun 24;44(8):934-40. doi: 10.1038/ng.2331. Nat Genet. 2012. PMID: 22729224 Free PMC article.
We identified de novo germline or postzygotic mutations in three core components of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway. These include 2 mutations in AKT3, 1 recurrent mutation in PIK3R2 in 11 unrelated families with MPPH and 15 mostly postzygotic mutation …
We identified de novo germline or postzygotic mutations in three core components of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway. Th …
YWHAB knockdown inhibits cell proliferation whilst promoting cell cycle arrest and apoptosis in colon cancer cells through PIK3R2.
Zhou X, Chen A, Zhang T. Zhou X, et al. Exp Ther Med. 2023 Mar 17;25(5):193. doi: 10.3892/etm.2023.11892. eCollection 2023 May. Exp Ther Med. 2023. PMID: 37090079 Free PMC article.
Colon cancer is one of the most common causes of cancer-associated mortality. ...Additionally, YWHAB was verified to bind to PIK3R2 and YWHAB knockdown decreased PIK3R2 expression. PIK3R2 overexpression by transfection of PIK3R2 overexpre …
Colon cancer is one of the most common causes of cancer-associated mortality. ...Additionally, YWHAB was verified to bind to …
Cotargeting of miR-126-3p and miR-221-3p inhibits PIK3R2 and PTEN, reducing lung cancer growth and metastasis by blocking AKT and CXCR4 signalling.
Di Paolo D, Pontis F, Moro M, Centonze G, Bertolini G, Milione M, Mensah M, Segale M, Petraroia I, Borzi C, Suatoni P, Brignole C, Perri P, Ponzoni M, Pastorino U, Sozzi G, Fortunato O. Di Paolo D, et al. Mol Oncol. 2021 Nov;15(11):2969-2988. doi: 10.1002/1878-0261.13036. Epub 2021 Jul 21. Mol Oncol. 2021. PMID: 34107168 Free PMC article.
Lung cancer is the leading cause of cancer-related death worldwide. Late diagnosis and metastatic dissemination contribute to its low survival rate. ...Simultaneous miRNA modulation reduced metastatic dissemination of lung cancer cells both in vitro and in vi …
Lung cancer is the leading cause of cancer-related death worldwide. Late diagnosis and metastatic dissemination contribute to …
miR-126 reduces trastuzumab resistance by targeting PIK3R2 and regulating AKT/mTOR pathway in breast cancer cells.
Fu R, Tong JS. Fu R, et al. J Cell Mol Med. 2020 Jul;24(13):7600-7608. doi: 10.1111/jcmm.15396. Epub 2020 May 15. J Cell Mol Med. 2020. PMID: 32410348 Free PMC article.
In comparison, inhibition of miR-126 in SKBR3 parental cells had the opposite effect of an increased resistance to trastuzumab as well as invasion and migration. It was also found that miR-126 directly targets PIK3R2 in breast cancer cells. PIK3R2-knockdown c …
In comparison, inhibition of miR-126 in SKBR3 parental cells had the opposite effect of an increased resistance to trastuzumab as well as in …
PIK3R2 predicts poor outcomes for patients with melanoma and contributes to the malignant progression via PI3K/AKT/NF-kappaB axis.
Wang J, Cai S, Xiong Q, Weng D, Wang Q, Ma Z. Wang J, et al. Clin Transl Oncol. 2023 May;25(5):1402-1412. doi: 10.1007/s12094-022-03036-x. Epub 2022 Dec 17. Clin Transl Oncol. 2023. PMID: 36528701
BACKGROUND: Melanoma is an aggressive form of skin cancer worldwide. Phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2) exerts carcinogenic roles in various tumors. ...RESULTS: PIK3R2 was highly expressed in melanoma tissues and cells, and PIK3R2 …
BACKGROUND: Melanoma is an aggressive form of skin cancer worldwide. Phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2) e …
FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells.
Zhang Y, Xiong X, Zhu Q, Zhang J, Chen S, Wang Y, Cao J, Chen L, Hou L, Zhao X, Hao P, Chen J, Zhuang M, Li D, Fan G. Zhang Y, et al. Elife. 2022 May 12;11:e76183. doi: 10.7554/eLife.76183. Elife. 2022. PMID: 35550247 Free PMC article.
Our previous work has demonstrated that non-receptor tyrosine kinase FER is upregulated in ovarian cancer, knocking down which attenuates metastatic phenotypes. However, due to the limited number of known substrates in the ovarian cancer context, the molecular basis …
Our previous work has demonstrated that non-receptor tyrosine kinase FER is upregulated in ovarian cancer, knocking down which attenu …
MiR-126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2-mediated PI3K/Akt signaling pathway.
Xiao J, Lin HY, Zhu YY, Zhu YP, Chen LW. Xiao J, et al. Onco Targets Ther. 2016 Aug 22;9:5181-93. doi: 10.2147/OTT.S105198. eCollection 2016. Onco Targets Ther. 2016. PMID: 27578985 Free PMC article. Retracted.
MATERIALS AND METHODS: A recombinant lentivirus (Lv) vector expressing miR-216 (Lv-miR-126) was successfully constructed, and Lv-miR-126 and Lv vector were transfected into the BLS cell line. A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstr …
MATERIALS AND METHODS: A recombinant lentivirus (Lv) vector expressing miR-216 (Lv-miR-126) was successfully constructed, and Lv-miR-126 and …
MicroRNA-126 inhibits proliferation and metastasis by targeting pik3r2 in prostate cancer.
Song L, Xie X, Yu S, Peng F, Peng L. Song L, et al. Mol Med Rep. 2016 Feb;13(2):1204-10. doi: 10.3892/mmr.2015.4661. Epub 2015 Dec 9. Mol Med Rep. 2016. PMID: 26677064 Free PMC article.
The dysregulation of miR-126 has been reported to correlate with the progression of several cancer types. The present study demonstrated that miR-126 was significantly downregulated in prostate cancer (PCa) tissues compared with normal prostate tissues. ...Additiona …
The dysregulation of miR-126 has been reported to correlate with the progression of several cancer types. The present study demonstra …
107 results