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ELF4 is a critical component of a miRNA-transcription factor network and is a bridge regulator of glioblastoma receptor signaling and lipid dynamics.
Kosti A, Chiou J, Guardia GDA, Lei X, Balinda H, Landry T, Lu X, Qiao M, Gilbert A, Brenner A, Galante PAF, Tiziani S, Penalva LOF. Kosti A, et al. Neuro Oncol. 2023 Mar 14;25(3):459-470. doi: 10.1093/neuonc/noac179. Neuro Oncol. 2023. PMID: 35862252 Free PMC article.
METHODS: In vitro and in vivo assays were used to assess ELF4 impact on cancer phenotypes. We characterized ELF4's mechanism of action via genomic and lipidomic analyses. ...CONCLUSIONS: We found that ELF4 is critical for the GBM cell identity by controlling genes of two d …
METHODS: In vitro and in vivo assays were used to assess ELF4 impact on cancer phenotypes. We characterized ELF4's mechanism of actio …
Gene co-expression network construction and analysis for identification of genetic biomarkers associated with glioblastoma multiforme using topological findings.
Redekar SS, Varma SL, Bhattacharjee A. Redekar SS, et al. J Egypt Natl Canc Inst. 2023 Jul 24;35(1):22. doi: 10.1186/s43046-023-00181-4. J Egypt Natl Canc Inst. 2023. PMID: 37482563
RESULTS: Ten key genes are identified as a potential biomarkers associated with GBM based on centrality measures applied to the disease network. These genes are SEMA3B, APS, SLC44A2, MARK2, PITPNM2, SFRP1, PRLH, DIP2C, CTSZ, and KRTAP4.2. Higher expression values of two ge …
RESULTS: Ten key genes are identified as a potential biomarkers associated with GBM based on centrality measures applied to the disease netw …