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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 1
1972 1
1974 1
1975 1
1976 3
1977 4
1978 3
1980 6
1981 1
1982 5
1983 4
1984 8
1985 12
1986 6
1987 31
1988 25
1989 36
1990 47
1991 55
1992 98
1993 81
1994 91
1995 142
1996 115
1997 136
1998 115
1999 129
2000 129
2001 122
2002 143
2003 135
2004 153
2005 162
2006 175
2007 154
2008 192
2009 205
2010 245
2011 247
2012 245
2013 255
2014 325
2015 346
2016 337
2017 322
2018 351
2019 361
2020 376
2021 391
2022 416
2023 453
2024 218

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6,896 results

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Page 1
Structure of the human PKD1-PKD2 complex.
Su Q, Hu F, Ge X, Lei J, Yu S, Wang T, Zhou Q, Mei C, Shi Y. Su Q, et al. Science. 2018 Sep 7;361(6406):eaat9819. doi: 10.1126/science.aat9819. Epub 2018 Aug 9. Science. 2018. PMID: 30093605
Mutations in two genes, PKD1 and PKD2, account for most cases of autosomal dominant polycystic kidney disease, one of the most common monogenetic disorders. Here we report the 3.6-angstrom cryo-electron microscopy structure of truncated human PK …
Mutations in two genes, PKD1 and PKD2, account for most cases of autosomal dominant polycystic kidney dis …
Deciphering Variability of PKD1 and PKD2 in an Italian Cohort of 643 Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).
Carrera P, Calzavara S, Magistroni R, den Dunnen JT, Rigo F, Stenirri S, Testa F, Messa P, Cerutti R, Scolari F, Izzi C, Edefonti A, Negrisolo S, Benetti E, Alibrandi MT, Manunta P, Boletta A, Ferrari M. Carrera P, et al. Sci Rep. 2016 Aug 8;6:30850. doi: 10.1038/srep30850. Sci Rep. 2016. PMID: 27499327 Free PMC article.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary kidney disease. We analysed PKD1 and PKD2, in a large cohort of 440 unrelated Italian patients with ADPKD and 203 relatives by direct sequencing and MLPA. …
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary kidney disease. We ana …
Autosomal dominant polycystic kidney disease.
Cornec-Le Gall E, Alam A, Perrone RD. Cornec-Le Gall E, et al. Lancet. 2019 Mar 2;393(10174):919-935. doi: 10.1016/S0140-6736(18)32782-X. Epub 2019 Feb 25. Lancet. 2019. PMID: 30819518 Review.
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and one of the most common causes of end-stage kidney disease. ...Implementation of these advances has the potential to delay kidney …
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and one …
Regulation of PKD2 channel function by TACAN.
Liu X, Zhang R, Fatehi M, Wang Y, Long W, Tian R, Deng X, Weng Z, Xu Q, Light PE, Tang J, Chen XZ. Liu X, et al. J Physiol. 2023 Jan;601(1):83-98. doi: 10.1113/JP283895. Epub 2022 Dec 13. J Physiol. 2023. PMID: 36420836 Free article.
Autosomal dominant polycystic kidney disease is caused by mutations in the membrane receptor PKD1 or the cation channel PKD2. ...TACAN inhibits the function of the PKD2 channel by physical interaction. The complex of PKD2 with TACA …
Autosomal dominant polycystic kidney disease is caused by mutations in the membrane receptor PKD1 or the cation …
Genetic Mechanisms of ADPKD.
Kim DY, Park JH. Kim DY, et al. Adv Exp Med Biol. 2016;933:13-22. doi: 10.1007/978-981-10-2041-4_2. Adv Exp Med Biol. 2016. PMID: 27730431 Review.
Autosomal dominant polycystic kidney disease is caused by mutation of PKD1 (polycystic kidney disease-1) or PKD2 (polycystic kidney disease-2). PKD1 and PKD2 encode PC1 (polycystin-1) and PC2 (polycystin-2), re …
Autosomal dominant polycystic kidney disease is caused by mutation of PKD1 (polycystic kidney dise …
Pkd2, mutations linking to autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates calcium signaling in fission yeast.
Koyano T, Fujimoto T, Onishi K, Matsuyama M, Fukushima M, Kume K. Koyano T, et al. Genes Cells. 2023 Nov;28(11):811-820. doi: 10.1111/gtc.13069. Epub 2023 Sep 18. Genes Cells. 2023. PMID: 37723847 Free article.
Autosomal dominant polycystic kidney disease (ADPKD) is a renal disorder caused by mutations in the PKD2 gene, which encodes polycystin-2/Pkd2, a transient receptor potential channel. ...However, human Pkd2 failed to suppress the l …
Autosomal dominant polycystic kidney disease (ADPKD) is a renal disorder caused by mutations in the PKD2 …
PKD2 gene variants in Chinese patients with autosomal dominant polycystic kidney disease.
Xu D, Bian R, Tuo S, Li X, Chen J, Xing X, Lu Y, Sun L, Tang X, Yu S, Mao Z, Ma Y, Mei C. Xu D, et al. Clin Genet. 2021 Sep;100(3):340-347. doi: 10.1111/cge.14008. Epub 2021 Jul 19. Clin Genet. 2021. PMID: 34101167
PKD2 gene variants account for 4.5% to 20% of patients with autosomal dominant polycystic kidney disease (ADPKD). Little is known about the clinical characteristics of PKD2 variants in Chinese patients with ADPKD. Herein, we performed a c …
PKD2 gene variants account for 4.5% to 20% of patients with autosomal dominant polycystic kidney disease …
De-repression of Pkd1 or Pkd2 attenuates ADPKD.
Carney EF. Carney EF. Nat Rev Nephrol. 2022 Nov;18(11):679. doi: 10.1038/s41581-022-00640-6. Nat Rev Nephrol. 2022. PMID: 36151325 No abstract available.
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery.
Tran T, Song CJ, Nguyen T, Cheng SY, McMahon JA, Yang R, Guo Q, Der B, Lindström NO, Lin DC, McMahon AP. Tran T, et al. Cell Stem Cell. 2022 Jul 7;29(7):1083-1101.e7. doi: 10.1016/j.stem.2022.06.005. Cell Stem Cell. 2022. PMID: 35803227 Free PMC article.
Single-cell transcriptomic profiling and immunofluorescence validation highlighted patterned nephron-like structures utilizing similar pathways, with distinct morphogenesis, to human nephrogenesis. To examine this platform for therapeutic screening, the polycystic kidne …
Single-cell transcriptomic profiling and immunofluorescence validation highlighted patterned nephron-like structures utilizing similar pathw …
Insights into Autosomal Dominant Polycystic Kidney Disease from Genetic Studies.
Lanktree MB, Haghighi A, di Bari I, Song X, Pei Y. Lanktree MB, et al. Clin J Am Soc Nephrol. 2021 May 8;16(5):790-799. doi: 10.2215/CJN.02320220. Epub 2020 Jul 20. Clin J Am Soc Nephrol. 2021. PMID: 32690722 Free PMC article. Review.
Autosomal dominant polycystic kidney disease is the most common monogenic cause of ESKD. ...By comprehensive screening of multiple cystic disease and modifier genes, targeted gene panel, whole-exome, or whole-genome sequencing is expected to improve bo …
Autosomal dominant polycystic kidney disease is the most common monogenic cause of ESKD. ...By comprehensive scr …
6,896 results