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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras.
Pearson M, Carbone R, Sebastiani C, Cioce M, Fagioli M, Saito S, Higashimoto Y, Appella E, Minucci S, Pandolfi PP, Pelicci PG. Pearson M, et al. Nature. 2000 Jul 13;406(6792):207-10. doi: 10.1038/35018127. Nature. 2000. PMID: 10910364
We found that oncogenic Ras upregulates PML expression, and overexpression of PML induces senescence in a p53-dependent manner. p53 is acetylated at lysine 382 upon Ras expression, an event that is essential fo …
We found that oncogenic Ras upregulates PML expression, and overexpression of PML induces senescence
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
Langley E, Pearson M, Faretta M, Bauer UM, Frye RA, Minucci S, Pelicci PG, Kouzarides T. Langley E, et al. EMBO J. 2002 May 15;21(10):2383-96. doi: 10.1093/emboj/21.10.2383. EMBO J. 2002. PMID: 12006491 Free PMC article.
Moreover, we show that SIRT1 and p53 co-localize in nuclear bodies upon PML upregulation. When overexpressed in primary mouse embryo fibroblasts (MEFs), SIRT1 antagonizes PML-induced acetylation of p53 and rescues PML-mediated p
Moreover, we show that SIRT1 and p53 co-localize in nuclear bodies upon PML upregulation. When overexpressed in primary mouse …