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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 4
1992 1
1993 3
1994 3
1995 1
1996 3
1997 5
1998 1
1999 1
2000 5
2001 5
2002 7
2003 9
2004 15
2005 28
2006 19
2007 26
2008 45
2009 53
2010 87
2011 130
2012 128
2013 127
2014 125
2015 132
2016 133
2017 120
2018 93
2019 113
2020 109
2021 61
2022 37
2023 45
2024 17

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1,507 results

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POU5F1 promotes the proliferation, migration, and invasion of gastric cancer cells by reducing the ubiquitination level of TRAF6.
Yang W, Cui X, Sun D, Sun G, Yan Z, Wei M, Wang Z, Yu W. Yang W, et al. Cell Death Dis. 2023 Dec 7;14(12):802. doi: 10.1038/s41419-023-06332-8. Cell Death Dis. 2023. PMID: 38062041 Free PMC article.
POU5F1 plays an important role in maintaining the cancer stem cell (CSC) -like properties of gastric cancer (GC) cells. ...The dysregulation of POU5F1 expression in GC tissues was analyzed using public databases and bioinformatics techniques, and the d …
POU5F1 plays an important role in maintaining the cancer stem cell (CSC) -like properties of gastric cancer (GC) cells. …
Leveraging a disulfidptosis-based signature to improve the survival and drug sensitivity of bladder cancer patients.
Chen H, Yang W, Li Y, Ma L, Ji Z. Chen H, et al. Front Immunol. 2023 May 30;14:1198878. doi: 10.3389/fimmu.2023.1198878. eCollection 2023. Front Immunol. 2023. PMID: 37325625 Free PMC article.
BACKGROUND: Disulfidptosis is a recently discovered form of cell death. However, its biological mechanisms in bladder cancer (BCa) are yet to be understood. METHODS: Disulfidptosis-related clusters were identified by consensus clustering. ...A series of phenotypic assays r …
BACKGROUND: Disulfidptosis is a recently discovered form of cell death. However, its biological mechanisms in bladder cancer (BCa) ar …
YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation.
Zhang C, Huang S, Zhuang H, Ruan S, Zhou Z, Huang K, Ji F, Ma Z, Hou B, He X. Zhang C, et al. Oncogene. 2020 Jun;39(23):4507-4518. doi: 10.1038/s41388-020-1303-7. Epub 2020 May 4. Oncogene. 2020. PMID: 32366907
N(6)-methyladenosine (m6A) RNA methylation contributes to the cancer stem cell (CSC) phenotype through regulating gene expression. ...Here, we show that YTHDF2 expression is negatively correlated with HCC patient survival in both data from the Cancer Genome Atlas (T …
N(6)-methyladenosine (m6A) RNA methylation contributes to the cancer stem cell (CSC) phenotype through regulating gene expression. .. …
Diagnostic significance and carcinogenic mechanism of pan-cancer gene POU5F1 in liver hepatocellular carcinoma.
He D, Zhang X, Tu J. He D, et al. Cancer Med. 2020 Dec;9(23):8782-8800. doi: 10.1002/cam4.3486. Epub 2020 Sep 26. Cancer Med. 2020. PMID: 32978904 Free PMC article.
GSEA indicated that POU5F1 participated in multiple cancer-related pathways and cell proliferation pathways. Moreover, CBX3, CCHCR1, and NFYC were filtered as the central hub genes of POU5F1. CONCLUSION: Our study identified POU5F1 as a pan-cancer …
GSEA indicated that POU5F1 participated in multiple cancer-related pathways and cell proliferation pathways. Moreover, CBX3, C …
The POU5F1 gene expression in colorectal cancer: a novel prognostic marker.
Miyoshi N, Fujino S, Ohue M, Yasui M, Takahashi Y, Sugimura K, Tomokuni A, Akita H, Kobayashi S, Takahashi H, Omori T, Miyata H, Yano M. Miyoshi N, et al. Surg Today. 2018 Jul;48(7):709-715. doi: 10.1007/s00595-018-1644-9. Epub 2018 Feb 27. Surg Today. 2018. PMID: 29488015
Few studies have examined the expression and significance of POU5F1 in cancer tissues. The aim of this study was to clarify its significance in colorectal cancer (CRC). ...The prognosis was significantly related to the serum TP53 levels, according to the P …
Few studies have examined the expression and significance of POU5F1 in cancer tissues. The aim of this study was to clarify it …
Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding.
Gkountela S, Castro-Giner F, Szczerba BM, Vetter M, Landin J, Scherrer R, Krol I, Scheidmann MC, Beisel C, Stirnimann CU, Kurzeder C, Heinzelmann-Schwarz V, Rochlitz C, Weber WP, Aceto N. Gkountela S, et al. Cell. 2019 Jan 10;176(1-2):98-112.e14. doi: 10.1016/j.cell.2018.11.046. Cell. 2019. PMID: 30633912 Free PMC article.
Here, we profile the DNA methylation landscape of single CTCs and CTC clusters from breast cancer patients and mouse models on a genome-wide scale. We find that binding sites for stemness- and proliferation-associated transcription factors are specifically hypomethylated i …
Here, we profile the DNA methylation landscape of single CTCs and CTC clusters from breast cancer patients and mouse models on a geno …
POU5F1/Oct-4 expression in breast cancer tissue is significantly associated with non-sentinel lymph node metastasis.
Cai S, Geng S, Jin F, Liu J, Qu C, Chen B. Cai S, et al. BMC Cancer. 2016 Mar 1;16:175. doi: 10.1186/s12885-015-1966-6. BMC Cancer. 2016. PMID: 26931354 Free PMC article.
BACKGROUND: At present, few studies have explored the significance of POU5F1 (also known as octamer-bingding factor, Oct-4 or Oct-3) expression in breast cancer tissues. ...RESULTS: POU5F1/Oct-4 expression levels in breast cancer tissues were significa …
BACKGROUND: At present, few studies have explored the significance of POU5F1 (also known as octamer-bingding factor, Oct-4 or Oct-3) …
HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1.
Fujino S, Miyoshi N, Ito A, Yasui M, Matsuda C, Ohue M, Uemura M, Mizushima T, Doki Y, Eguchi H. Fujino S, et al. Sci Rep. 2021 May 14;11(1):10363. doi: 10.1038/s41598-021-89126-2. Sci Rep. 2021. PMID: 33990627 Free PMC article.
POU5F1-expressing cells can self-renew and differentiate, contributing to metastasis formation in colorectal cancer (CRC), but it plays an important role in normal pluripotent stem cells. Here, we identified the CRC-specific gene, HNF1A, which is the downstream of …
POU5F1-expressing cells can self-renew and differentiate, contributing to metastasis formation in colorectal cancer (CRC), but …
Metastases and treatment-resistant lineages in patient-derived cancer cells of colorectal cancer.
Fujino S, Miyoshi N, Ito A, Hayashi R, Yasui M, Matsuda C, Ohue M, Horie M, Yachida S, Koseki J, Shimamura T, Hata T, Ogino T, Takahashi H, Uemura M, Mizushima T, Doki Y, Eguchi H. Fujino S, et al. Commun Biol. 2023 Nov 24;6(1):1191. doi: 10.1038/s42003-023-05562-y. Commun Biol. 2023. PMID: 37996567 Free PMC article.
However, which cells comprise the complex tumor lineages in recurrence and are key in metastasis are unknown in colorectal cancer (CRC). CRC with high expression of POU5F1 has a poor prognosis with a high incidence of liver metastatic recurrence. ...Sorted POU5F1 …
However, which cells comprise the complex tumor lineages in recurrence and are key in metastasis are unknown in colorectal cancer (CR …
On the potential origin and characteristics of cancer stem cells.
Trosko JE. Trosko JE. Carcinogenesis. 2021 Jul 16;42(7):905-912. doi: 10.1093/carcin/bgab042. Carcinogenesis. 2021. PMID: 34014276 Review.
The 'cancer stem cell' hypothesis has pointed to a specific target for new cancer therapies. The hypothesis is based on the observation that only the 'cancer stem cell' among the other heterogeneous cancer cells can sustain the growth of the cancer …
The 'cancer stem cell' hypothesis has pointed to a specific target for new cancer therapies. The hypothesis is based on the ob …
1,507 results