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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2013 1
2014 8
2015 3
2016 4
2017 7
2018 2
2019 4
2020 2
2021 2
2022 1
2025 0

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29 results

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Page 1
PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors.
Berthon AS, Szarek E, Stratakis CA. Berthon AS, et al. Front Cell Dev Biol. 2015 May 20;3:26. doi: 10.3389/fcell.2015.00026. eCollection 2015. Front Cell Dev Biol. 2015. PMID: 26042218 Free PMC article. Review.
Cyclic-AMP (cAMP)-dependent protein kinase (PKA) is the main effector of cAMP signaling in all tissues. ...More recently, mutations of PRKACA, the gene coding for the catalytic subunit C alpha (Calpha), were also identified in the pathogenesis o …
Cyclic-AMP (cAMP)-dependent protein kinase (PKA) is the main effector of cAMP signaling in all tissues. ...More recently, muta …
Protein kinase A defects and cortisol-producing adrenal tumors.
Zilbermint M, Stratakis CA. Zilbermint M, et al. Curr Opin Endocrinol Diabetes Obes. 2015 Jun;22(3):157-62. doi: 10.1097/MED.0000000000000149. Curr Opin Endocrinol Diabetes Obes. 2015. PMID: 25871963 Free PMC article. Review.
The first gene to be identified as causative of Cushing syndrome was PRKAR1A. We present an update on protein kinase A (PKA) defects and Cushing syndrome. RECENT FINDINGS: The cyclic AMP-dependent PKA catalytic subunit alpha …
The first gene to be identified as causative of Cushing syndrome was PRKAR1A. We present an update on protein kinase A …
Protein kinase A alterations in adrenocortical tumors.
Espiard S, Ragazzon B, Bertherat J. Espiard S, et al. Horm Metab Res. 2014 Nov;46(12):869-75. doi: 10.1055/s-0034-1385908. Epub 2014 Aug 8. Horm Metab Res. 2014. PMID: 25105543 Review.
Various molecular and cellular alterations of the cAMP pathway have been observed in endocrine tumors. Protein kinase A (PKA) is a central key component of the cAMP pathway. Molecular alterations of PKA subunits have been observed in adrenocortical …
Various molecular and cellular alterations of the cAMP pathway have been observed in endocrine tumors. Protein kinase …
Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma.
Tseng IC, Huang WJ, Jhuang YL, Chang YY, Hsu HP, Jeng YM. Tseng IC, et al. J Pathol. 2017 Jun;242(2):134-139. doi: 10.1002/path.4899. J Pathol. 2017. PMID: 28369983
Two-thirds of patients with Carney complex harbour germline mutations in PRKAR1A, which encodes the type I regulatory subunit of protein kinase A (PKA). Most studies have not found a mutation in PRKAR1A in sporadic cardiac myxoma cases. Recent studies …
Two-thirds of patients with Carney complex harbour germline mutations in PRKAR1A, which encodes the type I regulatory subunit of p …
Carney complex review: Genetic features.
Bosco Schamun MB, Correa R, Graffigna P, de Miguel V, Fainstein Day P. Bosco Schamun MB, et al. Endocrinol Diabetes Nutr (Engl Ed). 2018 Jan;65(1):52-59. doi: 10.1016/j.endinu.2017.09.006. Epub 2017 Nov 20. Endocrinol Diabetes Nutr (Engl Ed). 2018. PMID: 29162369 Review. English, Spanish.
Diagnostic criteria include myxoma, lentigines, and primary pigmented nodular adrenocortical disease, amongst other signs/symptoms. In most cases it is an autosomal dominant disease, and diagnosis therefore requires study and follow-up of the family members. Inactivating m …
Diagnostic criteria include myxoma, lentigines, and primary pigmented nodular adrenocortical disease, amongst other signs/symptoms. I …
PRKACA Mutations in Adrenal Adenomas: Genotype/Phenotype Correlations.
Dalmazi GD, Beuschlein F. Dalmazi GD, et al. Horm Metab Res. 2017 Apr;49(4):301-306. doi: 10.1055/s-0042-120416. Epub 2016 Nov 21. Horm Metab Res. 2017. PMID: 27871112 Review.
In particular, somatic mutations in the gene encoding the catalytic subunit alpha of protein kinase A (PKA) (PRKACA) were identified independently by several groups as the most frequently altered gene in cortisol-producing adenomas. Detai …
In particular, somatic mutations in the gene encoding the catalytic subunit alpha of protein kinase A (PK …
Pathogenesis of benign unilateral adrenocortical tumors: focus on cAMP/PKA pathway.
Weigand I. Weigand I. Minerva Endocrinol. 2019 Mar;44(1):25-32. doi: 10.23736/S0391-1977.18.02874-2. Epub 2018 Jul 2. Minerva Endocrinol. 2019. PMID: 29963826 Review.
Somatic mutations affecting genes in the cAMP/PKA (protein kinase A) signaling pathway have been described as causative for the pathogenesis of benign unilateral adrenocortical adenomas associated with cortisol over secretion. These include predominant …
Somatic mutations affecting genes in the cAMP/PKA (protein kinase A) signaling pathway have been described as causative …
Targeted Mutational Analysis of Cortisol-Producing Adenomas.
Rege J, Hoxie J, Liu CJ, Cash MN, Luther JM, Gellert L, Turcu AF, Else T, Giordano TJ, Udager AM, Rainey WE, Nanba K. Rege J, et al. J Clin Endocrinol Metab. 2022 Jan 18;107(2):e594-e603. doi: 10.1210/clinem/dgab682. J Clin Endocrinol Metab. 2022. PMID: 34534321 Free PMC article.
RESULTS: Somatic mutations were identified in 71.8% (56/78) of the CPAs. While PRKACA was the most frequently mutated gene in OCS CPAs (14/32, 43.8%), somatic genetic aberrations in CTNNB1 occurred in 56.5% (26/46) of the MACE CPAs. ...In addition to the known mutations, w …
RESULTS: Somatic mutations were identified in 71.8% (56/78) of the CPAs. While PRKACA was the most frequently mutated gene in OCS CPA …
Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas.
Weigand I, Ronchi CL, Rizk-Rabin M, Dalmazi GD, Wild V, Bathon K, Rubin B, Calebiro D, Beuschlein F, Bertherat J, Fassnacht M, Sbiera S. Weigand I, et al. Sci Rep. 2017 Mar 8;7(1):49. doi: 10.1038/s41598-017-00125-8. Sci Rep. 2017. PMID: 28250426 Free PMC article.
Somatic mutations in protein kinase A catalytic alpha subunit (PRKACA) were found to be causative for 30-40% of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active. ...In normal adrenal g …
Somatic mutations in protein kinase A catalytic alpha subunit (PRKACA) were found to be causative …
29 results