Calcified apoptotic vesicles from PROCR(+) fibroblasts initiate heterotopic ossification.
Yan J, Gao B, Wang C, Lu W, Qin W, Han X, Liu Y, Li T, Guo Z, Ye T, Wan Q, Xu H, Kang J, Lu N, Gao C, Qin Z, Yang C, Zheng J, Shen P, Niu L, Zou W, Jiao K.
Yan J, et al.
J Extracell Vesicles. 2024 Apr;13(4):e12425. doi: 10.1002/jev2.12425.
J Extracell Vesicles. 2024.
PMID: 38594791
Free PMC article.
Heterotopic ossification (HO) comprises the abnormal formation of ectopic bone in extraskeletal soft tissue. The factors that initiate HO remain elusive. ...More importantly, apoV-releasing inhibition or macrophage deletion both successfully reversed HO development. Thus, …
Heterotopic ossification (HO) comprises the abnormal formation of ectopic bone in extraskeletal soft tissue. The factors that initiat …