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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1998 1
1999 4
2000 4
2001 4
2002 4
2003 7
2004 12
2005 15
2006 30
2007 63
2008 93
2009 127
2010 199
2011 217
2012 230
2013 228
2014 193
2015 192
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2020 91
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1,954 results

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Page 1
Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumour-propagating cells and their dynamic cellular transition during liver cancer progression.
Zhou L, Yu KH, Wong TL, Zhang Z, Chan CH, Loong JH, Che N, Yu HJ, Tan KV, Tong M, Ngan ES, Ho JW, Ma S. Zhou L, et al. Gut. 2022 Aug;71(8):1656-1668. doi: 10.1136/gutjnl-2021-324321. Epub 2021 Sep 29. Gut. 2022. PMID: 34588223
OBJECTIVE: Hepatocellular carcinoma (HCC) has high intratumoral heterogeneity, which contributes to therapeutic resistance and tumour recurrence. We previously identified Prominin-1 (PROM1)/CD133 as an important liver cancer stem cell (CSC) marker in human HCC. ...D …
OBJECTIVE: Hepatocellular carcinoma (HCC) has high intratumoral heterogeneity, which contributes to therapeutic resistance and tumour recurr …
PROM1-mediated cell signal transduction in cancer stem cells and hepatocytes.
Bahn MS, Ko YG. Bahn MS, et al. BMB Rep. 2023 Feb;56(2):65-70. doi: 10.5483/BMBRep.2022-0203. BMB Rep. 2023. PMID: 36617467 Free PMC article. Review.
In addition, PROM1 is necessary to maintain cancer stem cell properties by activating PI3K and beta-Catenin. PROM1-deficienct mice also show distinct phenotypes in eyes, brain, peripheral nerves, and tooth. ...
In addition, PROM1 is necessary to maintain cancer stem cell properties by activating PI3K and beta-Catenin. PROM1-defi …
Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review).
Katoh M. Katoh M. Int J Oncol. 2017 Nov;51(5):1357-1369. doi: 10.3892/ijo.2017.4129. Epub 2017 Sep 19. Int J Oncol. 2017. PMID: 29048660 Free PMC article. Review.
Intra-tumor heterogeneity and cancer-cell plasticity give rise to therapeutic resistance and recurrence through clonal replacement and reactivation of dormant CSCs, respectively. WNT signaling cascades cross-talk with the FGF, Notch, Hedgehog and TGFbeta/BMP signaling casc …
Intra-tumor heterogeneity and cancer-cell plasticity give rise to therapeutic resistance and recurrence through clonal replacement an …
An Enhancer-Driven Stem Cell-Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer.
Liang X, Duronio GN, Yang Y, Bala P, Hebbar P, Spisak S, Sahgal P, Singh H, Zhang Y, Xie Y, Cejas P, Long HW, Bass AJ, Sethi NS. Liang X, et al. Gastroenterology. 2022 Jan;162(1):209-222. doi: 10.1053/j.gastro.2021.09.044. Epub 2021 Sep 25. Gastroenterology. 2022. PMID: 34571027 Free PMC article.
By binding to genome wide enhancers, SOX9 directly activates genes associated with Paneth and stem cell activity, including prominin 1 (PROM1). SOX9 up-regulates PROM1 via a Wnt-responsive intronic enhancer. A pentaspan transmembrane protein, PROM1 uses its f …
By binding to genome wide enhancers, SOX9 directly activates genes associated with Paneth and stem cell activity, including prominin 1 (P …
PROM1 and PROM2 expression differentially modulates clinical prognosis of cancer: a multiomics analysis.
Saha SK, Islam SMR, Kwak KS, Rahman MS, Cho SG. Saha SK, et al. Cancer Gene Ther. 2020 Apr;27(3-4):147-167. doi: 10.1038/s41417-019-0109-7. Epub 2019 Jun 5. Cancer Gene Ther. 2020. PMID: 31164716 Free PMC article.
Prominin 1 (PROM1) is considered a biomarker for cancer stem cells, although its biological role is unclear. Prominin 2 (PROM2) has also been associated with certain cancers. However, the prognostic value of PROM1 and PROM2 in cancer is controve …
Prominin 1 (PROM1) is considered a biomarker for cancer stem cells, although its biological role is unclear. Prominin 2 (PROM2 …
Identification and validation of PROM1 and CRTC2 mutations in lung cancer patients.
He Y, Li Y, Qiu Z, Zhou B, Shi S, Zhang K, Luo Y, Huang Q, Li W. He Y, et al. Mol Cancer. 2014 Jan 31;13:19. doi: 10.1186/1476-4598-13-19. Mol Cancer. 2014. PMID: 24484648 Free PMC article.
RESULTS: The data showed PROM1 (p. S281R) and CRTC2 (p. R379C) mutations, in 5 and 2 cases of these 343 sporadic lung cancer patients, respectively. ...CONCLUSIONS: The data from the current study demonstrated novel PROM1 and CRTC2 mutations, which could prom …
RESULTS: The data showed PROM1 (p. S281R) and CRTC2 (p. R379C) mutations, in 5 and 2 cases of these 343 sporadic lung cancer p …
H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.
Godfrey L, Crump NT, O'Byrne S, Lau IJ, Rice S, Harman JR, Jackson T, Elliott N, Buck G, Connor C, Thorne R, Knapp DJHF, Heidenreich O, Vyas P, Menendez P, Inglott S, Ancliff P, Geng H, Roberts I, Roy A, Milne TA. Godfrey L, et al. Leukemia. 2021 Jan;35(1):90-106. doi: 10.1038/s41375-020-0808-y. Epub 2020 Apr 2. Leukemia. 2021. PMID: 32242051 Free PMC article.
MLL-AF4 promotes leukemogenesis by activating key target genes, mainly through recruitment of DOT1L and increased histone H3 lysine-79 methylation (H3K79me2/3). One key MLL-AF4 target gene is PROM1, which encodes CD133 (Prominin-1). CD133 is a pentaspan transmembrane glyco …
MLL-AF4 promotes leukemogenesis by activating key target genes, mainly through recruitment of DOT1L and increased histone H3 lysine-79 methy …
Overexpression of PROM1 (CD133) confers poor prognosis in non-small cell lung cancer.
Qiu ZX, Zhao S, Mo XM, Li WM. Qiu ZX, et al. Int J Clin Exp Pathol. 2015 Jun 1;8(6):6589-95. eCollection 2015. Int J Clin Exp Pathol. 2015. PMID: 26261540 Free PMC article.
The aims of our research were to explore the expression profile of the PROM1 in non-small cell lung cancer (NSCLC) and to assess its possible role as a prognostic factor. ...The expression of PROM1 was significantly higher than normal tissue, and high levels …
The aims of our research were to explore the expression profile of the PROM1 in non-small cell lung cancer (NSCLC) and to asse …
Identification of human brain tumour initiating cells.
Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD, Dirks PB. Singh SK, et al. Nature. 2004 Nov 18;432(7015):396-401. doi: 10.1038/nature03128. Nature. 2004. PMID: 15549107 Free article.
The cancer stem cell (CSC) hypothesis suggests that neoplastic clones are maintained exclusively by a rare fraction of cells with stem cell properties. Although the existence of CSCs in human leukaemia is established, little evidence exists for CSCs in solid tumours, excep …
The cancer stem cell (CSC) hypothesis suggests that neoplastic clones are maintained exclusively by a rare fraction of cells with ste …
Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma.
Bamodu OA, Chang HL, Ong JR, Lee WH, Yeh CT, Tsai JT. Bamodu OA, et al. Cells. 2020 Mar 18;9(3):746. doi: 10.3390/cells9030746. Cells. 2020. PMID: 32197467 Free PMC article.
Despite accruing evidence implicating the PI3K/AKT signaling pathway in cancer-promoting hypoxia, cancerous cell proliferation and radiotherapy-resistance, it remains unclear which molecular constituent of the pathway facilitates adaptation of aggressive HCC cells t …
Despite accruing evidence implicating the PI3K/AKT signaling pathway in cancer-promoting hypoxia, cancerous cell proliferation …
1,954 results