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2004 1
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64 results

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Page 1
Shear Stress Drives the Cleavage Activation of Protease-Activated Receptor 2 by PRSS3/Mesotrypsin to Promote Invasion and Metastasis of Circulating Lung Cancer Cells.
Zhou M, Li K, Luo KQ. Zhou M, et al. Adv Sci (Weinh). 2023 Sep;10(25):e2301059. doi: 10.1002/advs.202301059. Epub 2023 Jul 3. Adv Sci (Weinh). 2023. PMID: 37395651 Free PMC article.
Half of the cancer cells can survive SS damage and show higher invasion ability. ...SS triggers PRSS3 to cleave the N-terminal inhibitory domain of PAR2 within 2 h. ...
Half of the cancer cells can survive SS damage and show higher invasion ability. ...SS triggers PRSS3 to cleave the N-terminal …
UHRF1/DNMT1-MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer.
Lin S, Xu H, Qin L, Pang M, Wang Z, Gu M, Zhang L, Zhao C, Hao X, Zhang Z, Ding W, Ren J, Huang J. Lin S, et al. Acta Pharm Sin B. 2023 May;13(5):2086-2106. doi: 10.1016/j.apsb.2023.02.015. Epub 2023 Feb 24. Acta Pharm Sin B. 2023. PMID: 37250150 Free PMC article.
As confusion mounts over RNA isoforms involved in phenotypic plasticity, aberrant CpG methylation-mediated disruption of alternative splicing is increasingly recognized as a driver of intratumor heterogeneity (ITH). Protease serine 3 (PRSS3), possessing four splice variant …
As confusion mounts over RNA isoforms involved in phenotypic plasticity, aberrant CpG methylation-mediated disruption of alternative splicin …
PRSS3 promotes tumour growth and metastasis of human pancreatic cancer.
Jiang G, Cao F, Ren G, Gao D, Bhakta V, Zhang Y, Cao H, Dong Z, Zang W, Zhang S, Wong HH, Hiley C, Crnogorac-Jurcevic T, Lemoine NR, Wang Y. Jiang G, et al. Gut. 2010 Nov;59(11):1535-44. doi: 10.1136/gut.2009.200105. Gut. 2010. PMID: 20947888
This study aimed to elucidate the role of PRSS3 in the growth and metastasis of human pancreatic cancer. METHODS: PRSS3 expression in human pancreatic cancer cell lines was detected by qPCR and immunoblotting. ...ERK inhibitor significantly delayed the …
This study aimed to elucidate the role of PRSS3 in the growth and metastasis of human pancreatic cancer. METHODS: PRSS3 …
PRSS3/mesotrypsin is a therapeutic target for metastatic prostate cancer.
Hockla A, Miller E, Salameh MA, Copland JA, Radisky DC, Radisky ES. Hockla A, et al. Mol Cancer Res. 2012 Dec;10(12):1555-66. doi: 10.1158/1541-7786.MCR-12-0314. Mol Cancer Res. 2012. PMID: 23258495 Free PMC article.
PRSS3/mesotrypsin is an atypical isoform of trypsin that has been associated with breast, lung, and pancreatic cancer cell malignancy. ...Using a mouse orthotopic model with bioluminescent imaging, we show that PRSS3/mesotrypsin is critical for prostate ca …
PRSS3/mesotrypsin is an atypical isoform of trypsin that has been associated with breast, lung, and pancreatic cancer cell mal …
High-level expression of PRSS3 correlates with metastasis and poor prognosis in patients with gastric cancer.
Wang F, Hu YL, Feng Y, Guo YB, Liu YF, Mao QS, Xue WJ. Wang F, et al. J Surg Oncol. 2019 Jun;119(8):1108-1121. doi: 10.1002/jso.25448. Epub 2019 Mar 25. J Surg Oncol. 2019. PMID: 30908656
BACKGROUND AND OBJECTIVES: Serine protease-3 (PRSS3) is a known contributor to the genesis and development of malignant tumors, although its role in gastric cancer (GC) is still unclear. ...CONCLUSIONS: PRSS3 appears to act as an oncogene of GC. High PRSS3 …
BACKGROUND AND OBJECTIVES: Serine protease-3 (PRSS3) is a known contributor to the genesis and development of malignant tumors, altho …
PRSS3 expression is associated with tumor progression and poor prognosis in epithelial ovarian cancer.
Ma R, Ye X, Cheng H, Ma Y, Cui H, Chang X. Ma R, et al. Gynecol Oncol. 2015 Jun;137(3):546-52. doi: 10.1016/j.ygyno.2015.02.022. Epub 2015 Feb 28. Gynecol Oncol. 2015. PMID: 25735255
OBJECTIVE: PRSS3 is an atypical isoform of trypsin that has been associated with breast, lung, and pancreatic cancers. This study aimed to elucidate the role of PRSS3 in tumor tissues of patients with epithelial ovarian cancer (EOC) and to investigate …
OBJECTIVE: PRSS3 is an atypical isoform of trypsin that has been associated with breast, lung, and pancreatic cancers. This st …
Circular RNA ADAM9 facilitates the malignant behaviours of pancreatic cancer by sponging miR-217 and upregulating PRSS3 expression.
Xing C, Ye H, Wang W, Sun M, Zhang J, Zhao Z, Jiang G. Xing C, et al. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3920-3928. doi: 10.1080/21691401.2019.1671856. Artif Cells Nanomed Biotechnol. 2019. PMID: 31810373
Pancreatic cancer (PC) is a highly lethal human cancer. We previously found that Serine protease 3 (PRSS3), as an oncogene, is significantly upregulated in PC. ...Stepwise mechanism studies indicated that circ-ADAM9 alleviated the inhibitory effect of miR-217 …
Pancreatic cancer (PC) is a highly lethal human cancer. We previously found that Serine protease 3 (PRSS3), as an oncog …
KRAS phosphorylation regulates cell polarization and tumorigenic properties in colorectal cancer.
Cabot D, Brun S, Paco N, Ginesta MM, Gendrau-Sanclemente N, Abuasaker B, Ruiz-Fariña T, Barceló C, Cuatrecasas M, Bosch M, Rentero C, Pons G, Estanyol JM, Capellà G, Jaumot M, Agell N. Cabot D, et al. Oncogene. 2021 Sep;40(38):5730-5740. doi: 10.1038/s41388-021-01967-3. Epub 2021 Jul 31. Oncogene. 2021. PMID: 34333552 Free article.
Oncogenic mutations of KRAS are found in the most aggressive human tumors, including colorectal cancer. It has been suggested that oncogenic KRAS phosphorylation at Ser181 modulates its activity and favors cell transformation. Using nonphosphorylatable (S181A), phosphomime …
Oncogenic mutations of KRAS are found in the most aggressive human tumors, including colorectal cancer. It has been suggested that on …
Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma.
Lin B, Zhou X, Lin S, Wang X, Zhang M, Cao B, Dong Y, Yang S, Wang JM, Guo M, Huang J. Lin B, et al. J Mol Med (Berl). 2017 Nov;95(11):1237-1249. doi: 10.1007/s00109-017-1578-5. Epub 2017 Aug 26. J Mol Med (Berl). 2017. PMID: 28844099 Free PMC article.
Protease, serine, 3 (PRSS3), a member of the trypsin family of serine proteases, has been shown to be aberrantly expressed in several cancer types and to play important roles in tumor progression and metastasis. ...In contrast, knockdown of PRSS3 by small int …
Protease, serine, 3 (PRSS3), a member of the trypsin family of serine proteases, has been shown to be aberrantly expressed in several …
64 results