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PSMD8 can serve as potential biomarker and therapeutic target of the PSMD family in ovarian cancer: based on bioinformatics analysis and in vitro validation.
Li X, Li X, Hu Y, Liu O, Wang Y, Li S, Yang Q, Lin B. Li X, et al. BMC Cancer. 2023 Jun 22;23(1):573. doi: 10.1186/s12885-023-11017-8. BMC Cancer. 2023. PMID: 37349676 Free PMC article.
Patients with high PSMD8 expression had poor prognosis. Overexpression of PSMD8 significantly enhanced the proliferation, migration, and invasion abilities in ovarian cancer cells. ...PSMDs, especially PSMD8, can serve as potential diagnostic and progn …
Patients with high PSMD8 expression had poor prognosis. Overexpression of PSMD8 significantly enhanced the proliferation, migr …
HYPK coordinates degradation of polyneddylated proteins by autophagy.
Ghosh DK, Ranjan A. Ghosh DK, et al. Autophagy. 2022 Aug;18(8):1763-1784. doi: 10.1080/15548627.2021.1997053. Epub 2021 Nov 26. Autophagy. 2022. PMID: 34836490 Free PMC article.
Thus, we propose an indispensable and additive role of neddylation and HYPK in clearance of protein aggregates by autophagy, resulting in cytoprotective effect during proteotoxic stress.Abbreviations: ATG5, autophagy related 5; ATG12, autophagy related 12; ATG14, autophagy relate …
Thus, we propose an indispensable and additive role of neddylation and HYPK in clearance of protein aggregates by autophagy, resulting in cy …
The Prognostic Significance of Proteasome 26S Subunit, Non-ATPase (PSMD) Genes for Bladder Urothelial Carcinoma Patients.
Salah Fararjeh A, Al-Khader A, Al-Saleem M, Abu Qauod R. Salah Fararjeh A, et al. Cancer Inform. 2021 Dec 22;20:11769351211067692. doi: 10.1177/11769351211067692. eCollection 2021. Cancer Inform. 2021. PMID: 34992336 Free PMC article.
PSMD2 and PSMD8 were significantly overexpressed in BLCA more than other types of cancer. High level of PSMD2 and PSMD8 predicted shorter overall (OS) and progression free survival (PFS) in BLCA patients. ...Overall, according to this study, PSMD2 and PSMD …
PSMD2 and PSMD8 were significantly overexpressed in BLCA more than other types of cancer. High level of PSMD2 and PSMD8 …
Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics.
Deng S, Zhou H, Xiong R, Lu Y, Yan D, Xing T, Dong L, Tang E, Yang H. Deng S, et al. Breast Cancer Res Treat. 2007 Jul;104(1):21-30. doi: 10.1007/s10549-006-9393-7. Epub 2006 Sep 27. Breast Cancer Res Treat. 2007. PMID: 17004105
Five genes of proteasome subunits (PSs), including PSMB5, PSMD1, PSMD2, PSMD8 and PSMD11, four genes of USPs, including USP9X, USP9Y, USP10 and USP25, and ubiquitin protein ligase E3A (UBE3A) were over-expressed (>3-fold) in breast cancer tissue compared to adjac …
Five genes of proteasome subunits (PSs), including PSMB5, PSMD1, PSMD2, PSMD8 and PSMD11, four genes of USPs, including USP9X, USP9Y, …
Identification of Potential Antigens for Developing mRNA Vaccine for Immunologically Cold Mesothelioma.
Zhang S, Li S, Wei Y, Xiong Y, Liu Q, Hu Z, Zeng Z, Tang F, Ouyang Y. Zhang S, et al. Front Cell Dev Biol. 2022 Jul 1;10:879278. doi: 10.3389/fcell.2022.879278. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35846349 Free PMC article.
Messenger RNA vaccines are considered to be a promising strategy in cancer immunotherapy, while their application on mesothelioma is still largely uncharacterized. ...A total of five potential tumor antigens correlated with prognosis and infiltration of antigen-presenting …
Messenger RNA vaccines are considered to be a promising strategy in cancer immunotherapy, while their application on mesothelioma is …
Metabolic reprogramming-related gene classifier distinguishes malignant from the benign pulmonary nodules.
Huang Y, Li N, Jiang J, Pei Y, Gao S, Qian Y, Xing Y, Zhou T, Lian Y, Shi M. Huang Y, et al. Heliyon. 2024 Aug 31;10(17):e37214. doi: 10.1016/j.heliyon.2024.e37214. eCollection 2024 Sep 15. Heliyon. 2024. PMID: 39296187 Free PMC article.
In our study, we aimed to develop and validate a gene classifier for lung cancer diagnosis. To identify the genes involved in this process, we used the weighted gene co-expression network analysis to analyze gene expression datasets from Gene Expression Omnibus (GEO). ...W …
In our study, we aimed to develop and validate a gene classifier for lung cancer diagnosis. To identify the genes involved in this pr …
Hsp90-associated DNA replication checkpoint protein and proteasome-subunit components are involved in the age-related macular degeneration.
Xing C, Liu XF, Zhang CF, Yang L. Xing C, et al. Chin Med J (Engl). 2021 Sep 20;134(19):2322-2332. doi: 10.1097/CM9.0000000000001773. Chin Med J (Engl). 2021. PMID: 34629418 Free PMC article.
Among the top ten hub genes, HSP90AA1, CHEK1, PSMA4, PSMD4, and PSMD8 were upregulated in the senescent ARPE-19 cells. Additionally, the drugs targeting HSP90AA1, CHEK1, and PSMA4 were identified. ...Targeting HSP90AA1, CHEK1, PSMA4, PSMD4, and/or PSMD8 genes throug …
Among the top ten hub genes, HSP90AA1, CHEK1, PSMA4, PSMD4, and PSMD8 were upregulated in the senescent ARPE-19 cells. Additionally, …
Exploring a novel four-gene system as a diagnostic and prognostic biomarker for triple-negative breast cancer, using clinical variables.
Ali F, Iqbal A, Azhar I, Qayyum A, Hassan SA, Hasan MSA, Jawi M, Hassan HM, Al-Emam A, Sajid M. Ali F, et al. Comput Biol Chem. 2024 Dec;113:108247. doi: 10.1016/j.compbiolchem.2024.108247. Epub 2024 Oct 15. Comput Biol Chem. 2024. PMID: 39427606
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with a poor prognosis. This research aims to find real hub genes for prognostic biomarkers of TNBC therapy. ...The KEGG pathway and GO analysis suggest that four genes (PSMB1, PSMC1, PSMF1, and PS …
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with a poor prognosis. This research aims to find real hub …
Screening of osteoarthritis diagnostic markers based on immune-related genes and immune infiltration.
Yuan WH, Xie QQ, Wang KP, Shen W, Feng XF, Liu Z, Shi JT, Zhang XB, Zhang K, Deng YJ, Zhou HY. Yuan WH, et al. Sci Rep. 2021 Mar 29;11(1):7032. doi: 10.1038/s41598-021-86319-7. Sci Rep. 2021. PMID: 33782454 Free PMC article.
The machine learning algorithm cross-identified 15 biomarkers (BTC, PSMD8, TLR3, IL7, APOD, CIITA, IFIH1, CDC42, FGF9, TNFAIP3, CX3CR1, ERAP2, SEMA3D, MPO, and plasma cells). ...
The machine learning algorithm cross-identified 15 biomarkers (BTC, PSMD8, TLR3, IL7, APOD, CIITA, IFIH1, CDC42, FGF9, TNFAIP3, CX3CR …
Aberrant ERG expression associates with downregulation of miR-4638-5p and selected genomic alterations in a subset of diffuse large B-cell lymphoma.
Zhang S, Wang L, Cheng L. Zhang S, et al. Mol Carcinog. 2019 Oct;58(10):1846-1854. doi: 10.1002/mc.23074. Epub 2019 Jun 24. Mol Carcinog. 2019. PMID: 31237044 Free article.
WES not only confirmed known gene mutations in DLBCLs but also revealed multiple novel gene mutations in POLA1, E2F1, PSMD8, AXIN1, GAB2, and GNB2L1, which occur more frequently in ERG+ DLBCLs. In conclusion, our studies demonstrated aberrant ERG expression in a subset of …
WES not only confirmed known gene mutations in DLBCLs but also revealed multiple novel gene mutations in POLA1, E2F1, PSMD8, AXIN1, G …
13 results