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Lnc-PTCHD4-AS inhibits gastric cancer through MSH2-MSH6 dimerization and ATM-p53-p21 activation.
Wang J, Mi Y, Sun X, Xue X, Zhao H, Zhang M, Hu B, Bukhari I, Zheng P. Wang J, et al. Aging (Albany NY). 2023 Nov 27;15(22):13558-13578. doi: 10.18632/aging.205329. Epub 2023 Nov 27. Aging (Albany NY). 2023. PMID: 38016120 Free PMC article.
Conserved long non-coding RNAs (lncRNAs) have not thoroughly been studied in many cancers, including gastric cancer (GC). We have identified a novel lncRNA PTCHD4-AS which was highly conserved between humans and mice and naturally downregulated in GC cell lin …
Conserved long non-coding RNAs (lncRNAs) have not thoroughly been studied in many cancers, including gastric cancer (GC). We h …
Membrane tension-mediated stiff and soft tumor subtypes closely associated with prognosis for prostate cancer patients.
Feng D, Wang J, Shi X, Li D, Wei W, Han P. Feng D, et al. Eur J Med Res. 2023 May 13;28(1):172. doi: 10.1186/s40001-023-01132-4. Eur J Med Res. 2023. PMID: 37179366 Free PMC article.
BACKGROUND: Prostate cancer (PCa) is usually considered as cold tumor. Malignancy is associated with cell mechanic changes that contribute to extensive cell deformation required for metastatic dissemination. ...The top ten mutation genes between stiff and soft subtypes wer …
BACKGROUND: Prostate cancer (PCa) is usually considered as cold tumor. Malignancy is associated with cell mechanic changes that contr …
Pathways to chromothripsis.
Ivkov R, Bunz F. Ivkov R, et al. Cell Cycle. 2015;14(18):2886-90. doi: 10.1080/15384101.2015.1068483. Epub 2015 Jul 15. Cell Cycle. 2015. PMID: 26178348 Free PMC article.
While the characterization of these derivative chromosomes has provided new insights into the processes by which cancer genomes can evolve, the underlying signaling events and molecular mechanisms remain unknown. ...
While the characterization of these derivative chromosomes has provided new insights into the processes by which cancer genomes can e …
Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition.
Huang MH, Chou YW, Li MH, Shih TE, Lin SZ, Chuang HM, Chiou TW, Su HL, Harn HJ. Huang MH, et al. Pharmacol Res. 2019 Jan;139:50-61. doi: 10.1016/j.phrs.2018.10.015. Epub 2018 Oct 29. Pharmacol Res. 2019. PMID: 30385365 Free article.
Annually, 48,000 people die from pancreatic ductal adenocarcinoma (PDAC), ranking it the fourth among cancer-related deaths in the United States. Currently, anti-cancer drugs are not effective against PDAC, and only extends survival by 3 months. ...Through microarra …
Annually, 48,000 people die from pancreatic ductal adenocarcinoma (PDAC), ranking it the fourth among cancer-related deaths in the Un …
A PTCH1 homolog transcriptionally activated by p53 suppresses Hedgehog signaling.
Chung JH, Larsen AR, Chen E, Bunz F. Chung JH, et al. J Biol Chem. 2014 Nov 21;289(47):33020-31. doi: 10.1074/jbc.M114.597203. Epub 2014 Oct 8. J Biol Chem. 2014. PMID: 25296753 Free PMC article.
The p53-mediated responses to DNA damage and the Hedgehog (Hh) signaling pathway are each recurrently dysregulated in many types of human cancer. Here we describe PTCH53, a p53 target gene that is homologous to the tumor suppressor gene PTCH1 and can function as a represso …
The p53-mediated responses to DNA damage and the Hedgehog (Hh) signaling pathway are each recurrently dysregulated in many types of human …