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Year Number of Results
1983 1
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2010 3
2011 1
2012 1
2014 1
2015 1
2016 3
2017 3
2018 2
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2022 4
2023 2
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31 results

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Page 1
PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development.
Sents W, Meeusen B, Kalev P, Radaelli E, Sagaert X, Miermans E, Haesen D, Lambrecht C, Dewerchin M, Carmeliet P, Westermarck J, Sablina A, Janssens V. Sents W, et al. Cancer Res. 2017 Dec 15;77(24):6825-6837. doi: 10.1158/0008-5472.CAN-16-2911. Epub 2017 Oct 18. Cancer Res. 2017. PMID: 29046336
Here, we identify a novel genetic mechanism by which PP2A function is recurrently affected in human cancer, involving haploinsufficiency of PPP2R4, a gene encoding the cellular PP2A activator PTPA. Notably, up to 70% of cancer patients showed a heterozygous d …
Here, we identify a novel genetic mechanism by which PP2A function is recurrently affected in human cancer, involving haploinsufficie …
Peptide PDHPS1 Inhibits Ovarian Cancer Growth through Disrupting YAP Signaling.
Pan X, Geng Z, Li J, Li X, Zhang M, Wang X, Cong Y, Huang K, Xu J, Jia X. Pan X, et al. Mol Cancer Ther. 2022 Jul 5;21(7):1160-1170. doi: 10.1158/1535-7163.MCT-21-0848. Mol Cancer Ther. 2022. PMID: 35545004
Our results indicated that PDHPS1 reduced the proliferation ability of ovarian cancer cells in vitro and inhibited the ovarian cancer growth in vivo. ...In conclusion, our study demonstrated that the endogenous peptide PDHPS1 serves as an antitumor peptide to inhibi …
Our results indicated that PDHPS1 reduced the proliferation ability of ovarian cancer cells in vitro and inhibited the ovarian can …
The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation.
Wang J, Ge P, Qiang L, Tian F, Zhao D, Chai Q, Zhu M, Zhou R, Meng G, Iwakura Y, Gao GF, Liu CH. Wang J, et al. Nat Commun. 2017 Aug 15;8(1):244. doi: 10.1038/s41467-017-00279-z. Nat Commun. 2017. PMID: 28811474 Free PMC article.
PtpA can bind directly to the promoter region of GADD45A in vitro. ...Here, the authors show that PtpA also enters the nucleus, affects the expression of several host genes, and promotes proliferation and migration of a cancer cell line....
PtpA can bind directly to the promoter region of GADD45A in vitro. ...Here, the authors show that PtpA also enters the nucleus …
Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1.
Kaur A, Westermarck J. Kaur A, et al. Biochem Soc Trans. 2016 Dec 15;44(6):1683-1693. doi: 10.1042/BST20160161. Biochem Soc Trans. 2016. PMID: 27913678 Review.
Importantly, recent studies have shown that PME-1 promotes oncogenic MAPK/ERK and AKT pathway activities in various cancer types. In human glioma, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance. We discuss the emerging cancer …
Importantly, recent studies have shown that PME-1 promotes oncogenic MAPK/ERK and AKT pathway activities in various cancer types. In …
Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors.
Xu Q, Wu C, Zhu Q, Gao R, Lu J, Valles-Colomer M, Zhu J, Yin F, Huang L, Ding L, Zhang X, Zhang Y, Xiong X, Bi M, Chen X, Zhu Y, Liu L, Liu Y, Chen Y, Fan J, Sun Y, Wang J, Cao Z, Fan C, Ehrlich SD, Segata N, Qin N, Qin H. Xu Q, et al. Nat Aging. 2022 May;2(5):438-452. doi: 10.1038/s43587-022-00193-0. Epub 2022 Apr 14. Nat Aging. 2022. PMID: 37118062
These included associations between FADS1/2 and arachidonate, PTPA and succinylcarnitine and FLVCR1 and choline. Our characterization of the extensive metagenomic and metabolomic remodeling that occurs in people reaching extreme ages may offer new targets for aging-related …
These included associations between FADS1/2 and arachidonate, PTPA and succinylcarnitine and FLVCR1 and choline. Our characterization …
In vivo pieces of the PP2A onco-puzzle fallen into place.
Meeusen B, Janssens V. Meeusen B, et al. Oncoscience. 2017 Dec 20;4(11-12):154-155. doi: 10.18632/oncoscience.384. eCollection 2017 Nov. Oncoscience. 2017. PMID: 29344545 Free PMC article. No abstract available.
Knockdown of phosphotyrosyl phosphatase activator induces apoptosis via mitochondrial pathway and the attenuation by simultaneous tau hyperphosphorylation.
Luo DJ, Feng Q, Wang ZH, Sun DS, Wang Q, Wang JZ, Liu GP. Luo DJ, et al. J Neurochem. 2014 Sep;130(6):816-25. doi: 10.1111/jnc.12761. Epub 2014 Jun 16. J Neurochem. 2014. PMID: 24821282 Free article.
Here, we investigated whether down-regulation of PTPA affects cell viability and the underlying mechanisms. We found that PTPA was located in the integral membrane of mitochondria, and knockdown of PTPA induced cell apoptosis in HEK293 and N2a cell lines. ... …
Here, we investigated whether down-regulation of PTPA affects cell viability and the underlying mechanisms. We found that PTPA …
PP2A drives the stemness in colorectal cancer cells by decreasing the Hippo signaling pathway.
Wang M, Chen T, Zhang J, Wen X. Wang M, et al. Cell Mol Biol (Noisy-le-grand). 2023 Dec 20;69(14):114-120. doi: 10.14715/cmb/2023.69.14.18. Cell Mol Biol (Noisy-le-grand). 2023. PMID: 38279464
Colorectal cancer (CRC) is one of the most prevalent malignancies. Accumulating evidence suggests that Hippo signaling pathway is a crucial signaling pathway that regulates stemness in multiple cancers, including CRC. ...Furthermore, we explore the transcription fac …
Colorectal cancer (CRC) is one of the most prevalent malignancies. Accumulating evidence suggests that Hippo signaling pathway is a c …
Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway.
Xiong YS, Liu FF, Liu D, Huang HZ, Wei N, Tan L, Chen JG, Man HY, Gong CX, Lu Y, Wang JZ, Zhu LQ. Xiong YS, et al. Aging Cell. 2015 Oct;14(5):867-77. doi: 10.1111/acel.12366. Epub 2015 Jun 26. Aging Cell. 2015. PMID: 26111662 Free PMC article.
Opposite effects of ERalpha and ERbeta have been found in estrogen-induced cancer cell proliferation and differentiation as well as in memory-related tasks. ...
Opposite effects of ERalpha and ERbeta have been found in estrogen-induced cancer cell proliferation and differentiation as well as i …
31 results