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Year Number of Results
1993 1
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2000 23
2001 15
2002 18
2003 22
2004 34
2005 46
2006 54
2007 36
2008 35
2009 42
2010 41
2011 35
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2013 45
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1,287 results

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Page 1
A comprehensive review of SHP2 and its role in cancer.
Asmamaw MD, Shi XJ, Zhang LR, Liu HM. Asmamaw MD, et al. Cell Oncol (Dordr). 2022 Oct;45(5):729-753. doi: 10.1007/s13402-022-00698-1. Epub 2022 Sep 6. Cell Oncol (Dordr). 2022. PMID: 36066752 Review.
Moreover, upregulated SHP2 expression or activity also decreases sensitivity of cancer cells to anticancer drugs. SHP2 is now considered as a compelling anticancer drug target and several classes of SHP2 inhibitors with different mode of action are developed with some alre …
Moreover, upregulated SHP2 expression or activity also decreases sensitivity of cancer cells to anticancer drugs. SHP2 is now conside …
A pan-cancer analysis confirms PTPN11's potential as a prognostic and immunological biomarker.
Cao Y, Duan H, Su A, Xu L, Lai B. Cao Y, et al. Aging (Albany NY). 2022 Jul 8;14(13):5590-5610. doi: 10.18632/aging.204171. Epub 2022 Jul 8. Aging (Albany NY). 2022. PMID: 35802774 Free PMC article.
There was an inconsistent expression of PTPN11 in different tumors, and the alteration of PTPN11 expression predicted the survival outcomes of cancer patients. ...Taken together, PTPN11 may become a new biomarker and target for cancer therapy... …
There was an inconsistent expression of PTPN11 in different tumors, and the alteration of PTPN11 expression predicted the surv …
Clinical considerations for the design of PROTACs in cancer.
Nieto-Jiménez C, Morafraile EC, Alonso-Moreno C, Ocaña A. Nieto-Jiménez C, et al. Mol Cancer. 2022 Mar 7;21(1):67. doi: 10.1186/s12943-022-01535-7. Mol Cancer. 2022. PMID: 35249548 Free PMC article. Review.
In this article we review the current development stage of PROTACs in cancer to categorize the best PROTAC construction. Targets including BCL2, CDK4 and MCL1 were highly expressed in all tumors; MCL1 was significantly increased in breast cancer and lung adenocarcin …
In this article we review the current development stage of PROTACs in cancer to categorize the best PROTAC construction. Targets incl …
SHP2: A Pleiotropic Target at the Interface of Cancer and Its Microenvironment.
Sodir NM, Pathria G, Adamkewicz JI, Kelley EH, Sudhamsu J, Merchant M, Chiarle R, Maddalo D. Sodir NM, et al. Cancer Discov. 2023 Nov 1;13(11):2339-2355. doi: 10.1158/2159-8290.CD-23-0383. Cancer Discov. 2023. PMID: 37682219 Free PMC article. Review.
The protein phosphatase SHP2/PTPN11 has been reported to be a key modulator of proliferative pathways in a wide range of malignancies. ...In this review, we will discuss the role of SHP2 in cancer and the tumor microenvironment, and the clinical strategies in which …
The protein phosphatase SHP2/PTPN11 has been reported to be a key modulator of proliferative pathways in a wide range of malignancies …
Proteogenomic and metabolomic characterization of human glioblastoma.
Wang LB, Karpova A, Gritsenko MA, Kyle JE, Cao S, Li Y, Rykunov D, Colaprico A, Rothstein JH, Hong R, Stathias V, Cornwell M, Petralia F, Wu Y, Reva B, Krug K, Pugliese P, Kawaler E, Olsen LK, Liang WW, Song X, Dou Y, Wendl MC, Caravan W, Liu W, Cui Zhou D, Ji J, Tsai CF, Petyuk VA, Moon J, Ma W, Chu RK, Weitz KK, Moore RJ, Monroe ME, Zhao R, Yang X, Yoo S, Krek A, Demopoulos A, Zhu H, Wyczalkowski MA, McMichael JF, Henderson BL, Lindgren CM, Boekweg H, Lu S, Baral J, Yao L, Stratton KG, Bramer LM, Zink E, Couvillion SP, Bloodsworth KJ, Satpathy S, Sieh W, Boca SM, Schürer S, Chen F, Wiznerowicz M, Ketchum KA, Boja ES, Kinsinger CR, Robles AI, Hiltke T, Thiagarajan M, Nesvizhskii AI, Zhang B, Mani DR, Ceccarelli M, Chen XS, Cottingham SL, Li QK, Kim AH, Fenyö D, Ruggles KV, Rodriguez H, Mesri M, Payne SH, Resnick AC, Wang P, Smith RD, Iavarone A, Chheda MG, Barnholtz-Sloan JS, Rodland KD, Liu T, Ding L; Clinical Proteomic Tumor Analysis Consortium. Wang LB, et al. Cancer Cell. 2021 Apr 12;39(4):509-528.e20. doi: 10.1016/j.ccell.2021.01.006. Epub 2021 Feb 11. Cancer Cell. 2021. PMID: 33577785 Free PMC article.
Glioblastoma (GBM) is the most aggressive nervous system cancer. Understanding its molecular pathogenesis is crucial to improving diagnosis and treatment. ...We identify key phosphorylation events (e.g., phosphorylated PTPN11 and PLCG1) as potential switches mediati …
Glioblastoma (GBM) is the most aggressive nervous system cancer. Understanding its molecular pathogenesis is crucial to improving dia …
Double-edged roles of protein tyrosine phosphatase SHP2 in cancer and its inhibitors in clinical trials.
Song Y, Zhao M, Zhang H, Yu B. Song Y, et al. Pharmacol Ther. 2022 Feb;230:107966. doi: 10.1016/j.pharmthera.2021.107966. Epub 2021 Aug 14. Pharmacol Ther. 2022. PMID: 34403682 Review.
Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) encoded by PTPN11 is the first identified oncogenic protein in protein tyrosine phosphatases family. ...Evidences suggest that by collaborating with other mutations in associated pathways, dysregulation of SHP …
Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) encoded by PTPN11 is the first identified oncogenic protein in protei …
The role of STAT3 in autophagy.
You L, Wang Z, Li H, Shou J, Jing Z, Xie J, Sui X, Pan H, Han W. You L, et al. Autophagy. 2015;11(5):729-39. doi: 10.1080/15548627.2015.1017192. Autophagy. 2015. PMID: 25951043 Free PMC article. Review.
Understanding the role of STAT3 signaling in the regulation of autophagy may provide insight into the classic autophagy model and also into cancer therapy, especially for the emerging targeted therapy, because a series of targeted agents execute antitumor activities via bl …
Understanding the role of STAT3 signaling in the regulation of autophagy may provide insight into the classic autophagy model and also into …
The role of Shp2 (PTPN11) in cancer.
Mohi MG, Neel BG. Mohi MG, et al. Curr Opin Genet Dev. 2007 Feb;17(1):23-30. doi: 10.1016/j.gde.2006.12.011. Epub 2007 Jan 16. Curr Opin Genet Dev. 2007. PMID: 17227708 Review.
Altered expression and/or mutations in PTKs are linked to many forms of cancer, yet until recently little was known about the roles of PTPs in normal cells or in cancer. ...
Altered expression and/or mutations in PTKs are linked to many forms of cancer, yet until recently little was known about the roles o …
The tyrosine phosphatase Shp2 (PTPN11) in cancer.
Chan G, Kalaitzidis D, Neel BG. Chan G, et al. Cancer Metastasis Rev. 2008 Jun;27(2):179-92. doi: 10.1007/s10555-008-9126-y. Cancer Metastasis Rev. 2008. PMID: 18286234 Review.
However, the Src homology-2 domain-containing phosphatase Shp2 (encoded by PTPN11) is a bona fide proto-oncogene. Germline mutations in PTPN11 cause Noonan and LEOPARD syndromes, whereas somatic PTPN11 mutations occur in several types of hematologic malignanc …
However, the Src homology-2 domain-containing phosphatase Shp2 (encoded by PTPN11) is a bona fide proto-oncogene. Germline mutations …
Protein Tyrosine Phosphatase Non-Receptor 11 (PTPN11/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC).
Richards CE, Elamin YY, Carr A, Gately K, Rafee S, Cremona M, Hanrahan E, Smyth R, Ryan D, Morgan RK, Kennedy S, Hudson L, Fay J, O'Byrne K, Hennessy BT, Toomey S. Richards CE, et al. Int J Mol Sci. 2023 Jun 23;24(13):10545. doi: 10.3390/ijms241310545. Int J Mol Sci. 2023. PMID: 37445722 Free PMC article.
PTPN11/Shp2 somatic mutations occur frequently in Juvenile myelomonocytic leukaemia (JMML); however, the role of mutated PTPN11 in lung cancer tumourigenesis and its utility as a therapeutic target has not been fully addressed. ...Ba/F3, NCI-H1703, and NCI-H1 …
PTPN11/Shp2 somatic mutations occur frequently in Juvenile myelomonocytic leukaemia (JMML); however, the role of mutated PTPN11 …
1,287 results