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Table representation of search results timeline featuring number of search results per year.

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89 results

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Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition.
Li J, Davidson D, Martins Souza C, Zhong MC, Wu N, Park M, Muller WJ, Veillette A. Li J, et al. Mol Cell Biol. 2015 Dec;35(23):4069-82. doi: 10.1128/MCB.00741-15. Epub 2015 Sep 21. Mol Cell Biol. 2015. PMID: 26391955 Free PMC article.
Here, we addressed this issue by examining the effect of PTPN12 deficiency on breast cancer progression in vivo, in a mouse model of ErbB2-dependent breast cancer using a conditional PTPN12-deficient mouse. ...Hence, loss of PTPN12 promoted tumo …
Here, we addressed this issue by examining the effect of PTPN12 deficiency on breast cancer progression in vivo, in a mouse mo …
Clinicopathological significance of PTPN12 expression in human breast cancer.
Xunyi Y, Zhentao Y, Dandan J, Funian L. Xunyi Y, et al. Braz J Med Biol Res. 2012 Dec;45(12):1334-40. doi: 10.1590/s0100-879x2012007500163. Epub 2012 Oct 9. Braz J Med Biol Res. 2012. PMID: 23044628 Free PMC article.
In the present study, we investigated the expression of PTPN12 protein by patients with breast cancer in a Chinese population and the relationship between PTPN12 expression levels and patient clinicopathological features and prognosis. ...Additionally, promot …
In the present study, we investigated the expression of PTPN12 protein by patients with breast cancer in a Chinese population …
Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer.
Nair A, Chung HC, Sun T, Tyagi S, Dobrolecki LE, Dominguez-Vidana R, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P, Schmitt E, Chan DW, Li H, Mao S, Petrovic I, Creighton CJ, Gutierrez C, Dubrulle J, Stossi F, Tyner JW, Lichtarge O, Lin CY, Zhang B, Scott KL, Hilsenbeck SG, Sun J, Yu X, Osborne CK, Schiff R, Christensen JG, Shields DJ, Rimawi MF, Ellis MJ, Shaw CA, Lewis MT, Westbrook TF. Nair A, et al. Nat Med. 2018 May;24(4):505-511. doi: 10.1038/nm.4507. Epub 2018 Mar 26. Nat Med. 2018. PMID: 29578538 Free PMC article.
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer diagnosed in more than 200,000 women each year and is recalcitrant to targeted therapies. ...Cancer-associated mutation of PTPN12 or reduced PTPN12 protein levels dim …
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer diagnosed in more than 200,000 women each year …
Important roles of protein tyrosine phosphatase PTPN12 in tumor progression.
Lee C, Rhee I. Lee C, et al. Pharmacol Res. 2019 Jun;144:73-78. doi: 10.1016/j.phrs.2019.04.011. Epub 2019 Apr 5. Pharmacol Res. 2019. PMID: 30959160 Review.
According to its newly identified roles and functions, PTPN12 is considered a promising therapeutic target against critical diseases, including cancer, diabetes, metabolic disease and autoimmune diseases. In this review, we provide an overview of PTPs and discuss th …
According to its newly identified roles and functions, PTPN12 is considered a promising therapeutic target against critical diseases, …
Identifying the role of PTPN12 expression in predicting the efficacy of capecitabine to neoadjuvant chemotherapy in breast cancer treatment.
Wang YY, Liu H, Mao XY, Jin F, Ma B, Jiang JY, Cao Y. Wang YY, et al. Eur Rev Med Pharmacol Sci. 2016 Aug;20(16):3400-9. Eur Rev Med Pharmacol Sci. 2016. PMID: 27608899 Free article.
OBJECTIVE: The aim of this study was to investigate the expression of PTPN12 in human breast cancer and its role in predicting the efficacy of neoadjuvant chemotherapy (NACT) for breast cancer. PATIENTS AND METHODS: The PTPN12 expression levels were as …
OBJECTIVE: The aim of this study was to investigate the expression of PTPN12 in human breast cancer and its role in predicting …
PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling.
Harris IS, Blaser H, Moreno J, Treloar AE, Gorrini C, Sasaki M, Mason JM, Knobbe CB, Rufini A, Hallé M, Elia AJ, Wakeham A, Tremblay ML, Melino G, Done S, Mak TW. Harris IS, et al. Oncogene. 2014 Feb 20;33(8):1047-54. doi: 10.1038/onc.2013.24. Epub 2013 Feb 25. Oncogene. 2014. PMID: 23435421
As tight regulation of ROS to sustain survival is a key feature of cancer cells, we examined PTPN12 levels in tumors from a cohort of breast cancer patients. Patients whose tumors showed high levels of PTPN12 transcripts had a significantly poorer prog …
As tight regulation of ROS to sustain survival is a key feature of cancer cells, we examined PTPN12 levels in tumors from a co …
Epigenetic regulation of protein tyrosine phosphatase PTPN12 in triple-negative breast cancer.
Thummuri D, Kumar S, Surapaneni SK, Tikoo K. Thummuri D, et al. Life Sci. 2015 Jun 1;130:73-80. doi: 10.1016/j.lfs.2015.03.016. Epub 2015 Mar 25. Life Sci. 2015. PMID: 25817229
AIMS: The present study showed that the expression of PTPN12 is epigenetically regulated. 5-Azacytidine (5-Azac), a DNA hypomethylating agent, significantly increased the expression of PTPN12 at low concentrations (1muM and 2.5muM) and decreased the expression of …
AIMS: The present study showed that the expression of PTPN12 is epigenetically regulated. 5-Azacytidine (5-Azac), a DNA hypomethylati …
A missense variant in PTPN12 associated with the risk of colorectal cancer by modifying Ras/MEK/ERK signaling.
Shen N, Li L, Xu W, Tian J, Yang Y, Zhu Y, Gong Y, Ke J, Gong J, Chang J, Zhong R, Miao X. Shen N, et al. Cancer Epidemiol. 2019 Apr;59:109-114. doi: 10.1016/j.canep.2019.01.013. Epub 2019 Feb 4. Cancer Epidemiol. 2019. PMID: 30731403
BACKGROUND: The classical protein tyrosine phosphatases (PTPs) have been widely reported to be associated with various human malignancies including colorectal cancer (CRC). However, there are few comprehensive analyses of the association between the classical PTP genes and …
BACKGROUND: The classical protein tyrosine phosphatases (PTPs) have been widely reported to be associated with various human malignancies in …
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.
Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF. Sun T, et al. Cell. 2011 Mar 4;144(5):703-18. doi: 10.1016/j.cell.2011.02.003. Cell. 2011. PMID: 21376233 Free PMC article.
Among breast cancers, triple-negative breast cancer (TNBC) is the most poorly understood and is refractory to current targeted therapies. ...The tumorigenic and metastatic potential of PTPN12-deficient TNBC cells is severely impaired upon restoration of PT …
Among breast cancers, triple-negative breast cancer (TNBC) is the most poorly understood and is refractory to current targeted …
GABA(B1e) promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12.
Wei B, Zhu Y, Yang P, Han Y, Wang S, Wang X, Xia S, Song X, Zhang Z, Wang S, Rondard P, Pin JP, Jiang X, Liu J. Wei B, et al. iScience. 2021 Oct 16;24(11):103311. doi: 10.1016/j.isci.2021.103311. eCollection 2021 Nov 19. iScience. 2021. PMID: 34778730 Free PMC article.
We revealed that GB(1e) is largely expressed in human breast cancer (BrCa) cell lines as well as in BrCa tissues where it is upregulated. ...We propose that GB(1e) favors EGFR signaling by interacting with PTPN12 to disrupt the interaction between EGFR and PTPN12 …
We revealed that GB(1e) is largely expressed in human breast cancer (BrCa) cell lines as well as in BrCa tissues where it is upregula …
89 results