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2012 5
2013 5
2014 1
2015 6
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2017 7
2018 5
2019 8
2020 12
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88 results

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PTPN14 promotes gastric cancer progression by PI3KA/AKT/mTOR pathway.
Li H, Guan B, Liu S, Liu H, Song L, Zhang G, Zhao R, Zhou C, Gao P. Li H, et al. Cell Death Dis. 2023 Mar 10;14(3):188. doi: 10.1038/s41419-023-05712-4. Cell Death Dis. 2023. PMID: 36898991 Free PMC article.
The online database indicated that PTPN14 may be a poor prognostic factor for gastric cancer. However, the function and underlying mechanism of PTPN14 in gastric cancer remain unclear. We collected gastric cancer tissues and detected the express …
The online database indicated that PTPN14 may be a poor prognostic factor for gastric cancer. However, the function and underl …
PTPN14 Mutations and Cervical Cancer.
Lehrer S, Rheinstein PH. Lehrer S, et al. Cancer Diagn Progn. 2021 Jul 3;1(4):275-277. doi: 10.21873/cdp.10035. eCollection 2021 Sep-Oct. Cancer Diagn Progn. 2021. PMID: 35403138 Free PMC article.
A follow-up investigation of 24 cancers and three benign tumor types showed that PTPN14 loss-of-function variants were associated with high risk of cervical cancer and early age at diagnosis. We used the Cancer Genome Atlas (TCGA) to further evaluate t …
A follow-up investigation of 24 cancers and three benign tumor types showed that PTPN14 loss-of-function variants were associa …
PTPN14 acts as a candidate tumor suppressor in prostate cancer and inhibits cell proliferation and invasion through modulating LATS1/YAP signaling.
Wang R, Du Y, Shang J, Dang X, Niu G. Wang R, et al. Mol Cell Probes. 2020 Oct;53:101642. doi: 10.1016/j.mcp.2020.101642. Epub 2020 Jul 7. Mol Cell Probes. 2020. PMID: 32645410
However, whether PTPN14 plays a role in prostate cancer has not been well investigated. Herein, we evaluated the function and potential underlying mechanism of PTPN14 in prostate cancer. Decreased PTPN14 expression was detected in prostate ca …
However, whether PTPN14 plays a role in prostate cancer has not been well investigated. Herein, we evaluated the function and …
microRNA-217 suppressed epithelial-to-mesenchymal transition through targeting PTPN14 in gastric cancer.
Chen G, Yang Z, Feng M, Wang Z. Chen G, et al. Biosci Rep. 2020 Jan 31;40(1):BSR20193176. doi: 10.1042/BSR20193176. Biosci Rep. 2020. PMID: 31793993 Free PMC article.
Moreover, miR-217 markedly suppressed the metastasis and invasion of gastric cancer cell line in vitro. Furthermore, miR-217 inhibited the expression of PTPN14 by directly targeting its 3'UTR. Moreover, the down-regulation of PTPN14 reduced the metastasis and …
Moreover, miR-217 markedly suppressed the metastasis and invasion of gastric cancer cell line in vitro. Furthermore, miR-217 inhibite …
A small molecule targeting the interaction between human papillomavirus E7 oncoprotein and cellular phosphatase PTPN14 exerts antitumoral activity in cervical cancer cells.
Bertagnin C, Messa L, Pavan M, Celegato M, Sturlese M, Mercorelli B, Moro S, Loregian A. Bertagnin C, et al. Cancer Lett. 2023 Sep 1;571:216331. doi: 10.1016/j.canlet.2023.216331. Epub 2023 Aug 1. Cancer Lett. 2023. PMID: 37532093 Free article.
We discovered a compound able to inhibit the E7/PTPN14 interaction in vitro and to rescue PTPN14 levels in cells, leading to a reduction in viability, proliferation, migration, and cancer-stem cell potential of HPV-positive cervical cancer cells. Mecha …
We discovered a compound able to inhibit the E7/PTPN14 interaction in vitro and to rescue PTPN14 levels in cells, leading to a …
Loss-of-Function Variants in the Tumor-Suppressor Gene PTPN14 Confer Increased Cancer Risk.
Olafsdottir T, Stacey SN, Sveinbjornsson G, Thorleifsson G, Norland K, Sigurgeirsson B, Thorisdottir K, Kristjansson AK, Tryggvadottir L, Sarin KY, Benediktsson R, Jonasson JG, Sigurdsson A, Jonasdottir A, Kristmundsdottir S, Jonsson H, Gylfason A, Oddsson A, Fridriksdottir R, Gudjonsson SA, Zink F, Lund SH, Rognvaldsson S, Melsted P, Steinthorsdottir V, Gudmundsson J, Mikaelsdottir E, Olason PI, Stefansdottir L, Eggertsson HP, Halldorsson BV, Thorsteinsdottir U, Agustsson TT, Olafsson K, Olafsson JH, Sulem P, Rafnar T, Gudbjartsson DF, Stefansson K. Olafsdottir T, et al. Cancer Res. 2021 Apr 15;81(8):1954-1964. doi: 10.1158/0008-5472.CAN-20-3065. Epub 2021 Feb 18. Cancer Res. 2021. PMID: 33602785
A follow-up investigation of 24 cancers and three benign tumor types showed that PTPN14 loss-of-function variants are associated with high risk of cervical cancer (OR, 12.7, P = 1.6 10(-4)) and low age at diagnosis. ...SIGNIFICANCE: This study identifies the …
A follow-up investigation of 24 cancers and three benign tumor types showed that PTPN14 loss-of-function variants are associat …
MicroRNA-217 suppressed epithelial-to-mesenchymal transition in gastric cancer metastasis through targeting PTPN14.
Liu YP, Sun XH, Cao XL, Jiang WW, Wang XX, Zhang YF, Wang JL. Liu YP, et al. Eur Rev Med Pharmacol Sci. 2017 Apr;21(8):1759-1767. Eur Rev Med Pharmacol Sci. 2017. PMID: 28485805 Free article.
OBJECTIVE: Gastric cancer (GC) is the third leading cause of cancer-related deaths while the mechanisms underlying its metastasis are not fully understood. ...Furthermore, the loss of PTPN14 induced by miR-217 or si-PTPN14 reduced the metastasis and in …
OBJECTIVE: Gastric cancer (GC) is the third leading cause of cancer-related deaths while the mechanisms underlying its metasta …
Exosomal CircPRRX1 Enhances Doxorubicin Resistance in Gastric Cancer by Regulating MiR-3064-5p/PTPN14 Signaling.
Wang S, Ping M, Song B, Guo Y, Li Y, Jia J. Wang S, et al. Yonsei Med J. 2020 Sep;61(9):750-761. doi: 10.3349/ymj.2020.61.9.750. Yonsei Med J. 2020. PMID: 32882759 Free PMC article.
PURPOSE: Gastric cancer (GC) is a malignant tumor with a high mortality rate. Drug resistance is a major obstacle to GC therapy. ...Levels of circPRRX1, miR-3064-5p, and nonreceptor tyrosine phosphatase 14 (PTPN14) were detected by quantitative real-time PCR or West …
PURPOSE: Gastric cancer (GC) is a malignant tumor with a high mortality rate. Drug resistance is a major obstacle to GC therapy. ...L …
A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer.
Mello SS, Valente LJ, Raj N, Seoane JA, Flowers BM, McClendon J, Bieging-Rolett KT, Lee J, Ivanochko D, Kozak MM, Chang DT, Longacre TA, Koong AC, Arrowsmith CH, Kim SK, Vogel H, Wood LD, Hruban RH, Curtis C, Attardi LD. Mello SS, et al. Cancer Cell. 2017 Oct 9;32(4):460-473.e6. doi: 10.1016/j.ccell.2017.09.007. Cancer Cell. 2017. PMID: 29017057 Free PMC article.
Ptpn14 encodes a negative regulator of the Yap oncoprotein and is necessary and sufficient for pancreatic cancer suppression, like p53. We show that p53 deficiency promotes Yap signaling and that PTPN14 and TP53 mutations are mutually exclusive in human ca …
Ptpn14 encodes a negative regulator of the Yap oncoprotein and is necessary and sufficient for pancreatic cancer suppression, …
PTPN14 phosphatase and YAP promote TGFbeta signalling in rheumatoid synoviocytes.
Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V, Sacchetti C, Zoccheddu M, Lonic A, Li X, Boyle DL, Hammaker D, Meng TC, Liu L, Corr M, Stanford SM, Lewis M, Wang W, Firestein GS, Khew-Goodall Y, Pitzalis C, Bottini N. Bottini A, et al. Ann Rheum Dis. 2019 May;78(5):600-609. doi: 10.1136/annrheumdis-2018-213799. Epub 2019 Feb 26. Ann Rheum Dis. 2019. PMID: 30808624 Free PMC article.
OBJECTIVE: We aimed to understand the role of the tyrosine phosphatase PTPN14-which in cancer cells modulates the Hippo pathway by retaining YAP in the cytosol-in fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA). ...In RA FLS, PTPN1 …
OBJECTIVE: We aimed to understand the role of the tyrosine phosphatase PTPN14-which in cancer cells modulates the Hippo pathwa …
88 results