Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 1
1995 9
1996 11
1997 25
1998 33
1999 36
2000 23
2001 24
2002 18
2003 14
2004 21
2005 14
2006 12
2007 7
2008 11
2009 16
2010 14
2011 16
2012 19
2013 20
2014 32
2015 32
2016 26
2017 24
2018 24
2019 14
2020 27
2021 26
2022 28
2023 16
2024 8

Text availability

Article attribute

Article type

Publication date

Search Results

543 results

Results by year

Filters applied: . Clear all
Page 1
PTPN6-EGFR Protein Complex: A Novel Target for Colon Cancer Metastasis.
Liu G, Zhang Y, Huang Y, Yuan X, Cao Z, Zhao Z. Liu G, et al. J Oncol. 2022 Feb 11;2022:7391069. doi: 10.1155/2022/7391069. eCollection 2022. J Oncol. 2022. PMID: 35186080 Free PMC article.
The expression level of PTPN6 mRNA in different colon cancer cell lines was detected by qPCR. ...CO-IP assay was used to detect the interaction protein of PTPN6. PTPN6 was highly expressed in colorectal cancer tissues. High expression of PTPN …
The expression level of PTPN6 mRNA in different colon cancer cell lines was detected by qPCR. ...CO-IP assay was used to detec …
PTPN6 promotes chemosensitivity of colorectal cancer cells via inhibiting the SP1/MAPK signalling pathway.
Fang H, Ma W, Guo X, Wang J. Fang H, et al. Cell Biochem Funct. 2021 Apr;39(3):392-400. doi: 10.1002/cbf.3604. Epub 2020 Dec 7. Cell Biochem Funct. 2021. PMID: 33615510
The abnormal expression of protein tyrosine phosphatase nonreceptor type 6 (PTPN6) has been proved to be associated with the progression of colorectal cancer. ...To evaluate the effects of PTPN6 on the proliferation and survival of colorectal cancer ce …
The abnormal expression of protein tyrosine phosphatase nonreceptor type 6 (PTPN6) has been proved to be associated with the progress …
The Analysis of PTPN6 for Bladder Cancer: An Exploratory Study Based on TCGA.
Shen C, Liu J, Wang J, Yang X, Niu H, Wang Y. Shen C, et al. Dis Markers. 2020 May 13;2020:4312629. doi: 10.1155/2020/4312629. eCollection 2020. Dis Markers. 2020. PMID: 32454905 Free PMC article.
However, the role of PTPN6 in bladder cancer (BC) remains unclear. The purpose of this study was to explore the prognostic value of PTPN6 in BC. RNA-seq data from The Cancer Genome Atlas (TCGA) was used to identify the expression level of PTPN6 …
However, the role of PTPN6 in bladder cancer (BC) remains unclear. The purpose of this study was to explore the prognostic val …
The role of STAT3 in autophagy.
You L, Wang Z, Li H, Shou J, Jing Z, Xie J, Sui X, Pan H, Han W. You L, et al. Autophagy. 2015;11(5):729-39. doi: 10.1080/15548627.2015.1017192. Autophagy. 2015. PMID: 25951043 Free PMC article. Review.
Understanding the role of STAT3 signaling in the regulation of autophagy may provide insight into the classic autophagy model and also into cancer therapy, especially for the emerging targeted therapy, because a series of targeted agents execute antitumor activities via bl …
Understanding the role of STAT3 signaling in the regulation of autophagy may provide insight into the classic autophagy model and also into …
A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis.
Yao F, Deng Y, Zhao Y, Mei Y, Zhang Y, Liu X, Martinez C, Su X, Rosato RR, Teng H, Hang Q, Yap S, Chen D, Wang Y, Chen MM, Zhang M, Liang H, Xie D, Chen X, Zhu H, Chang JC, You MJ, Sun Y, Gan B, Ma L. Yao F, et al. Nat Commun. 2021 Dec 17;12(1):7333. doi: 10.1038/s41467-021-27452-9. Nat Commun. 2021. PMID: 34921145 Free PMC article.
The growing knowledge of ferroptosis has suggested the role and therapeutic potential of ferroptosis in cancer, but has not been translated into effective therapy. Liver cancer, primarily hepatocellular carcinoma (HCC), is highly lethal with limited treatment option …
The growing knowledge of ferroptosis has suggested the role and therapeutic potential of ferroptosis in cancer, but has not been tran …
Single-cell and bulk sequencing analyses reveal the immune suppressive role of PTPN6 in glioblastoma.
Zhang X, Chen J, Zhang M, Liu S, Wang T, Wu T, Li B, Zhao S, Wang H, Li L, Wang C, Huang L. Zhang X, et al. Aging (Albany NY). 2023 Sep 21;15(18):9822-9841. doi: 10.18632/aging.205052. Epub 2023 Sep 21. Aging (Albany NY). 2023. PMID: 37737713 Free PMC article.
Glioblastoma (GBM) is a highly malignant brain cancer with a poor prognosis despite standard treatments. This investigation aimed to explore the feasibility of PTPN6 to combat GBM with immunotherapy. ...The outcomes of our study indicate that PTPN6 is a promi …
Glioblastoma (GBM) is a highly malignant brain cancer with a poor prognosis despite standard treatments. This investigation aimed to …
Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation.
Speir M, Nowell CJ, Chen AA, O'Donnell JA, Shamie IS, Lakin PR, D'Cruz AA, Braun RO, Babon JJ, Lewis RS, Bliss-Moreau M, Shlomovitz I, Wang S, Cengia LH, Stoica AI, Hakem R, Kelliher MA, O'Reilly LA, Patsiouras H, Lawlor KE, Weller E, Lewis NE, Roberts AW, Gerlic M, Croker BA. Speir M, et al. Nat Immunol. 2020 Jan;21(1):54-64. doi: 10.1038/s41590-019-0550-7. Epub 2019 Dec 9. Nat Immunol. 2020. PMID: 31819256 Free PMC article.
Ptpn6 is a cytoplasmic phosphatase that functions to prevent autoimmune and interleukin-1 (IL-1) receptor-dependent, caspase-1-independent inflammatory disease. Conditional deletion of Ptpn6 in neutrophils (Ptpn6(PMN)) is sufficient to initiate IL-1 receptor- …
Ptpn6 is a cytoplasmic phosphatase that functions to prevent autoimmune and interleukin-1 (IL-1) receptor-dependent, caspase-1-indepe …
Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer.
Liu C, Wang X, Qin W, Tu J, Li C, Zhao W, Ma L, Liu B, Qiu H, Yuan X. Liu C, et al. Cancer Commun (Lond). 2023 Apr;43(4):435-454. doi: 10.1002/cac2.12412. Epub 2023 Feb 28. Cancer Commun (Lond). 2023. PMID: 36855844 Free PMC article.
BACKGROUND: Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) have shown a moderate response in colorectal cancer (CRC) with deficient mismatch repair (dMMR) functions and poor response in patients wi …
BACKGROUND: Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) have …
SHP-2 and PD-L1 Inhibition Combined with Radiotherapy Enhances Systemic Antitumor Effects in an Anti-PD-1-Resistant Model of Non-Small Cell Lung Cancer.
Chen D, Barsoumian HB, Yang L, Younes AI, Verma V, Hu Y, Menon H, Wasley M, Masropour F, Mosaffa S, Ozgen T, Klein K, Cortez MA, Welsh JW. Chen D, et al. Cancer Immunol Res. 2020 Jul;8(7):883-894. doi: 10.1158/2326-6066.CIR-19-0744. Epub 2020 Apr 16. Cancer Immunol Res. 2020. PMID: 32299915 Free PMC article.
Immune checkpoint inhibitors, such as anti-PD-1/PD-L1, have emerged as promising therapies for advanced non-small cell lung cancer (NSCLC). However, approximately 80% of patients do not respond to immunotherapy given alone because of intrinsic or acquired resistance. Radio …
Immune checkpoint inhibitors, such as anti-PD-1/PD-L1, have emerged as promising therapies for advanced non-small cell lung cancer (N …
543 results