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Did you mean ptprj cancer (122 results)?
PTPRK suppresses progression and chemo-resistance of colon cancer cells via direct inhibition of pro-oncogenic CD133.
Matsushita M, Mori Y, Uchiumi K, Ogata T, Nakamura M, Yoda H, Soda H, Takiguchi N, Nabeya Y, Shimozato O, Ozaki T. Matsushita M, et al. FEBS Open Bio. 2019 May;9(5):935-946. doi: 10.1002/2211-5463.12636. Epub 2019 Apr 18. FEBS Open Bio. 2019. PMID: 30947381 Free PMC article.
In this study, we have demonstrated that knockdown of PTPRK potentiates the pro-oncogenic CD133-AKT pathway in colon cancer cells. ...Together, our present observations strongly suggest that the CD133-PTPRK axis plays a pivotal role in the regulation of colon …
In this study, we have demonstrated that knockdown of PTPRK potentiates the pro-oncogenic CD133-AKT pathway in colon cancer ce …
PTPRK Expression Is Downregulated in Drug Resistant Ovarian Cancer Cell Lines, and Especially in ALDH1A1 Positive CSCs-Like Populations.
Świerczewska M, Sterzyńska K, Wojtowicz K, Kaźmierczak D, Iżycki D, Nowicki M, Zabel M, Januchowski R. Świerczewska M, et al. Int J Mol Sci. 2019 Apr 25;20(8):2053. doi: 10.3390/ijms20082053. Int J Mol Sci. 2019. PMID: 31027318 Free PMC article.
Background: Ovarian cancer is the 7th most common cancer and 8th most mortal cancer among woman. ...Additionally, the lower PTPRK expression was observed in Aldehyde Dehydrogenase 1 Family Member A1 (ALDH1A1) positive cancer stem cells (CSCs) po …
Background: Ovarian cancer is the 7th most common cancer and 8th most mortal cancer among woman. ...Additionally, the l …
Protein tyrosine phosphatase kappa (PTPRK) is a negative regulator of adhesion and invasion of breast cancer cells, and associates with poor prognosis of breast cancer.
Sun PH, Ye L, Mason MD, Jiang WG. Sun PH, et al. J Cancer Res Clin Oncol. 2013 Jul;139(7):1129-39. doi: 10.1007/s00432-013-1421-5. Epub 2013 Apr 4. J Cancer Res Clin Oncol. 2013. PMID: 23552869
The present study investigated the expression of PTPRK in breast cancer and the biological impact of PTPRK on breast cancer cells. ...Knockdown of PTPRK in breast cancer cells was performed using a specific anti-PTPRK transgene. .. …
The present study investigated the expression of PTPRK in breast cancer and the biological impact of PTPRK on breast …
Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer.
Jeong JH, Yun JW, Kim HY, Heo CY, Lee S. Jeong JH, et al. PLoS One. 2022 Sep 21;17(9):e0274555. doi: 10.1371/journal.pone.0274555. eCollection 2022. PLoS One. 2022. PMID: 36129915 Free PMC article.
However, till now, therapeutic targets and actionable drugs are limited in this subtype of cancer. MATERIALS AND METHOD: The purpose of this study is to identify key genes and cancer-related pathways specific for P:R fusion-positive CRC. ...Among these pathways, the …
However, till now, therapeutic targets and actionable drugs are limited in this subtype of cancer. MATERIALS AND METHOD: The purpose …
Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles.
Yan HHN, Siu HC, Ho SL, Yue SSK, Gao Y, Tsui WY, Chan D, Chan AS, Wong JWH, Man AHY, Lee BCH, Chan ASY, Chan AKW, Hui HS, Cheung AKL, Law WL, Lo OSH, Yuen ST, Clevers H, Leung SY. Yan HHN, et al. Gut. 2020 Dec;69(12):2165-2179. doi: 10.1136/gutjnl-2019-320019. Epub 2020 Mar 26. Gut. 2020. PMID: 32217638
OBJECTIVE: Sporadic early-onset colorectal cancer (EOCRC) has bad prognosis, yet is poorly represented by cell line models. We examine the key mutational and transcriptomic alterations in an organoid biobank enriched in EOCRCs. DESIGN: We established paired cancer ( …
OBJECTIVE: Sporadic early-onset colorectal cancer (EOCRC) has bad prognosis, yet is poorly represented by cell line models. We examin …
The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer.
Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C. Chang LS, et al. Elife. 2020 Jan 14;9:e51248. doi: 10.7554/eLife.51248. Elife. 2020. PMID: 31934854 Free PMC article.
Here we identify the tumor suppressor Protein tyrosine phosphatase receptor-type kappa (PTPRK), as a Wnt inhibitor in human cancer cells and in the Spemann organizer of Xenopus embryos. ...Our discovery of PTPRK as a negative regulator of Wnt receptor turnove …
Here we identify the tumor suppressor Protein tyrosine phosphatase receptor-type kappa (PTPRK), as a Wnt inhibitor in human cancer …
miRNA-627 inhibits cell proliferation and cell migration, promotes cell apoptosis in prostate cancer cells through upregulating MAP3K1, PTPRK and SRA1.
Zhang M, Wang F, Zhang X. Zhang M, et al. Int J Clin Exp Pathol. 2018 Jan 1;11(1):255-261. eCollection 2018. Int J Clin Exp Pathol. 2018. PMID: 31938108 Free PMC article.
Recently, it has been found that miRNA-627 might mediate colorectal cancer cells as a tumor-suppressor. However, its role on prostate cancer cells remains unknown. ...Additionally, miRNA-627 promoted cell apoptosis and upregulated the mRNA levels of MAP3K1, PTPRK …
Recently, it has been found that miRNA-627 might mediate colorectal cancer cells as a tumor-suppressor. However, its role on prostate …
Downregulation of PTPRK Promotes Cell Proliferation and Metastasis of NSCLC by Enhancing STAT3 Activation.
Xu X, Li D, Liu J, Ma Z, Huang H, Min L, Dai L, Dong S. Xu X, et al. Anal Cell Pathol (Amst). 2019 Jan 29;2019:4265040. doi: 10.1155/2019/4265040. eCollection 2019. Anal Cell Pathol (Amst). 2019. PMID: 30838170 Free PMC article.
However, its expression and biological roles in non-small-cell lung cancer (NSCLC) have not yet been investigated. METHODS: PTPRK expression in NSCLC tissues and cell lines was examined using real-time PCR and western blotting. In addition, the effects of PTPRK …
However, its expression and biological roles in non-small-cell lung cancer (NSCLC) have not yet been investigated. METHODS: PTPRK …
A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling.
Kim M, Reinhard C, Niehrs C. Kim M, et al. Elife. 2021 Sep 30;10:e70885. doi: 10.7554/eLife.70885. Elife. 2021. PMID: 34590584 Free PMC article.
Previously, we showed that dephosphorylation of an endocytic tyrosine motif (4Y motif) in ZNRF3 by protein tyrosine phosphatase receptor-type kappa (PTPRK) promotes ZNRF3 internalization and Wnt receptor degradation (Chang et al 2020). ...Conversely, depletion or pharmacol …
Previously, we showed that dephosphorylation of an endocytic tyrosine motif (4Y motif) in ZNRF3 by protein tyrosine phosphatase receptor-typ …
Regulation of development and cancer by the R2B subfamily of RPTPs and the implications of proteolysis.
Craig SE, Brady-Kalnay SM. Craig SE, et al. Semin Cell Dev Biol. 2015 Jan;37:108-18. doi: 10.1016/j.semcdb.2014.09.004. Epub 2014 Sep 16. Semin Cell Dev Biol. 2015. PMID: 25223585 Free PMC article. Review.
The R2B subfamily is composed of four members: PTPmu (PTPRM), PTPrho (PTPRT), PTPkappa (PTPRK), and PCP-2 (PTPRU). The effects of this small subfamily of RPTPs is far reaching, influencing several developmental processes and cancer. ...This review discusses the curr …
The R2B subfamily is composed of four members: PTPmu (PTPRM), PTPrho (PTPRT), PTPkappa (PTPRK), and PCP-2 (PTPRU). The effects of thi …
72 results