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66 results

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Page 1
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G. Dai W, et al. Cancer Commun (Lond). 2022 Sep;42(9):848-867. doi: 10.1002/cac2.12341. Epub 2022 Jul 29. Cancer Commun (Lond). 2022. PMID: 35904817 Free PMC article.
BACKGROUND: Abnormal expression of protein tyrosine phosphatases (PTPs) has been reported to be a crucial cause of cancer. As a member of PTPs, protein tyrosine phosphatase receptor type O (PTPRO) has been revealed to play tumor suppressive roles in several cance …
BACKGROUND: Abnormal expression of protein tyrosine phosphatases (PTPs) has been reported to be a crucial cause of cancer. As a membe …
PTPRO is a therapeutic target and correlated with immune infiltrates in pancreatic cancer.
Hou X, Du J, Fang H. Hou X, et al. J Cancer. 2021 Oct 30;12(24):7445-7453. doi: 10.7150/jca.64661. eCollection 2021. J Cancer. 2021. PMID: 35003364 Free PMC article.
Currently, the roles of PTPRO in human cancers remain elusive. Herein, we performed bioinformatic analyses and revealed the potential oncogenic role of PTPRO in specific cancer types. Further in vitro experiments indicated that inhibition of PTPRO …
Currently, the roles of PTPRO in human cancers remain elusive. Herein, we performed bioinformatic analyses and revealed the po …
Tyrosine Phosphatase PTPRO Deficiency in ERBB2-Positive Breast Cancer Contributes to Poor Prognosis and Lapatinib Resistance.
Dong H, Du L, Cai S, Lin W, Chen C, Still M, Yao Z, Coppes RP, Pan Y, Zhang D, Gao S, Zhang H. Dong H, et al. Front Pharmacol. 2022 Apr 1;13:838171. doi: 10.3389/fphar.2022.838171. eCollection 2022. Front Pharmacol. 2022. PMID: 35431974 Free PMC article.
Results from both human breast cancer cells with PTPRO knockdown or overexpression and mouse embryonic fibroblasts (MEFs) which derived from Ptpro (+/+) and Ptpro (-/-) mice with then stably transfected plasmid FUGW-Erbb2 consistently demonstrated the …
Results from both human breast cancer cells with PTPRO knockdown or overexpression and mouse embryonic fibroblasts (MEFs) whic …
Single-cell transcriptomic analysis deciphers heterogenous cancer stem-like cells in colorectal cancer and their organ-specific metastasis.
Li R, Liu X, Huang X, Zhang D, Chen Z, Zhang J, Bai R, Zhang S, Zhao H, Xu Z, Zeng L, Zhuang L, Wen S, Wu S, Li M, Zuo Z, Lin J, Lin D, Zheng J. Li R, et al. Gut. 2024 Feb 23;73(3):470-484. doi: 10.1136/gutjnl-2023-330243. Gut. 2024. PMID: 38050068 Free PMC article.
OBJECTIVE: Metastasis is the major cause of cancer death. However, what types of heterogenous cancer cells in primary tumour and how they metastasise to the target organs remain largely undiscovered. ...In the oCRC microenvironment, myofibroblasts provide cancer …
OBJECTIVE: Metastasis is the major cause of cancer death. However, what types of heterogenous cancer cells in primary tumour a …
PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET.
Dong H, Lin W, Du L, Yao Z, Li F, Chen S, Huang Y, Ren H, Luo Y, Cai S, Chen Y, Tang H, Qiu X, Pan Y, Huang X, Zhang D, Gao S, Yeung SJ, Zhang H. Dong H, et al. Cancer Lett. 2023 Jul 28;567:216283. doi: 10.1016/j.canlet.2023.216283. Epub 2023 Jun 17. Cancer Lett. 2023. PMID: 37331584
Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. ...Patients with PTPRO(low)/p-MET(high) had significan …
Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PT …
Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment.
Yao Z, Dong H, Zhu J, Du L, Luo Y, Liu Q, Liu S, Lin Y, Wang L, Wang S, Wei W, Zhang K, Huang Q, Yu X, Zhao W, Xu H, Qiu X, Pan Y, Huang X, Jim Yeung SC, Zhang D, Zhang H. Yao Z, et al. JCI Insight. 2023 Jul 24;8(14):e166306. doi: 10.1172/jci.insight.166306. JCI Insight. 2023. PMID: 37485875 Free PMC article.
To understand the protective role of PTPRO in CRCI, a mouse model was generated by treating Ptpro-/- female mice with doxorubicin (DOX) because Ptpro-/- female mice are more vulnerable to DOX, showing cognitive impairments and neurodegeneration. ...On the oth …
To understand the protective role of PTPRO in CRCI, a mouse model was generated by treating Ptpro-/- female mice with doxorubi …
PTPRO-related CD8(+) T-cell signatures predict prognosis and immunotherapy response in patients with breast cancer.
Dong H, Xie C, Yao Z, Zhao R, Lin Y, Luo Y, Chen S, Qin Y, Chen Y, Zhang H. Dong H, et al. Front Immunol. 2022 Aug 8;13:947841. doi: 10.3389/fimmu.2022.947841. eCollection 2022. Front Immunol. 2022. PMID: 36003382 Free PMC article.
Protein tyrosine phosphatase receptor type O (PTPRO) regulates multiple kinases and pathways and has been implied to play a regulatory role in immune cell infiltration in various cancers. ...PTPRO-based PTS provides a new immune cell paradigm for prognosis, w …
Protein tyrosine phosphatase receptor type O (PTPRO) regulates multiple kinases and pathways and has been implied to play a regulator …
MiR-6803-5p Promotes Cancer Cell Proliferation and Invasion via PTPRO/NF-kappaB Axis in Colorectal Cancer.
Yan S, Cheng M, Duan Q, Wang Z, Gao W, Ren B, Xu D. Yan S, et al. Mediators Inflamm. 2019 Nov 20;2019:8128501. doi: 10.1155/2019/8128501. eCollection 2019. Mediators Inflamm. 2019. PMID: 31827380 Free PMC article.
Accumulated studies have implicated microRNAs (miRNAs) exert modifying effects on colorectal cancer (CRC). Protein tyrosine phosphatase, receptor type O (PTPRO) has been identified as a tumor suppressor in several kinds of cancer, including CRC. ...Negative c …
Accumulated studies have implicated microRNAs (miRNAs) exert modifying effects on colorectal cancer (CRC). Protein tyrosine phosphata …
PTPRO promoter methylation is predictive of poorer outcome for HER2-positive breast cancer: indication for personalized therapy.
Huang YT, Li FF, Ke C, Li Z, Li ZT, Zou XF, Zheng XX, Chen YP, Zhang H. Huang YT, et al. J Transl Med. 2013 Oct 3;11:245. doi: 10.1186/1479-5876-11-245. J Transl Med. 2013. PMID: 24090193 Free PMC article.
We examined the methylation status of the PTPRO gene promoter in breast cancer and evaluated the correlation between PTPRO promoter methylation and both clinicopathological parameters and prognosis of breast cancer patients. ...CONCLUSIONS: PTPRO …
We examined the methylation status of the PTPRO gene promoter in breast cancer and evaluated the correlation between PTPRO …
PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2.
Dong H, Ma L, Gan J, Lin W, Chen C, Yao Z, Du L, Zheng L, Ke C, Huang X, Song H, Kumar R, Yeung SC, Zhang H. Dong H, et al. Oncogene. 2017 Jan 19;36(3):410-422. doi: 10.1038/onc.2016.213. Epub 2016 Jun 27. Oncogene. 2017. PMID: 27345410 Free PMC article.
The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptionally repressed in cancers and signifies poor prognosis of breast cancer patients. ...Taken together, PTPRO inhibited ERBB2-driven breast cancer through dephosph …
The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptionally repressed in cancers and signifies p …
66 results