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Did you mean pvri cancer (9 results)?
Mendelian randomization and transcriptomic analysis reveal an inverse causal relationship between Alzheimer's disease and cancer.
Dong Z, Xu M, Sun X, Wang X. Dong Z, et al. J Transl Med. 2023 Aug 4;21(1):527. doi: 10.1186/s12967-023-04357-3. J Transl Med. 2023. PMID: 37542274 Free PMC article.
Colocalization analysis uncovered PVRIG upregulation to be a risk factor for AD. Transcriptomic analysis showed that PVRIG expression had significant negative correlations with stemness scores, and positive correlations with antitumor immune responses and overall su …
Colocalization analysis uncovered PVRIG upregulation to be a risk factor for AD. Transcriptomic analysis showed that PVRIG exp …
Emergence of the CD226 Axis in Cancer Immunotherapy.
Conner M, Hance KW, Yadavilli S, Smothers J, Waight JD. Conner M, et al. Front Immunol. 2022 Jun 24;13:914406. doi: 10.3389/fimmu.2022.914406. eCollection 2022. Front Immunol. 2022. PMID: 35812451 Free PMC article. Review.
By virtue of the clinical progression of TIGIT antagonists and emergence of novel CD96- and PVRIG-based approaches, our overall understanding of the 'CD226 axis' in cancer immunotherapy is starting to take shape. ...This review provides an overview of the CD226 axis …
By virtue of the clinical progression of TIGIT antagonists and emergence of novel CD96- and PVRIG-based approaches, our overall under …
DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy.
Sanchez-Correa B, Valhondo I, Hassouneh F, Lopez-Sejas N, Pera A, Bergua JM, Arcos MJ, Bañas H, Casas-Avilés I, Durán E, Alonso C, Solana R, Tarazona R. Sanchez-Correa B, et al. Cancers (Basel). 2019 Jun 23;11(6):877. doi: 10.3390/cancers11060877. Cancers (Basel). 2019. PMID: 31234588 Free PMC article. Review.
Analysis of DNAM-1, TIGIT, TACTILE and PVRIG on human NK cells from solid cancer or leukemia patients will clarify the role of these receptors in cancer surveillance. Overall, it can be speculated that in cancer patients the TIGIT/PVRIG pathways …
Analysis of DNAM-1, TIGIT, TACTILE and PVRIG on human NK cells from solid cancer or leukemia patients will clarify the role of …
PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8(+) T-cell Function.
Whelan S, Ophir E, Kotturi MF, Levy O, Ganguly S, Leung L, Vaknin I, Kumar S, Dassa L, Hansen K, Bernados D, Murter B, Soni A, Taube JM, Fader AN, Wang TL, Shih IM, White M, Pardoll DM, Liang SC. Whelan S, et al. Cancer Immunol Res. 2019 Feb;7(2):257-268. doi: 10.1158/2326-6066.CIR-18-0442. Epub 2019 Jan 18. Cancer Immunol Res. 2019. PMID: 30659054 Free PMC article.
Tumor cells coexpressing PVR and PVRL2 were observed in multiple tumor types, with highest coexpression in endometrial cancers. Tumor cells expressing either PVR or PVRL2 were also present in numbers that varied with the cancer type, with ovarian cancers havi …
Tumor cells coexpressing PVR and PVRL2 were observed in multiple tumor types, with highest coexpression in endometrial cancers. Tumor …
Innate Immune Checkpoint Inhibitors: The Next Breakthrough in Medical Oncology?
Lentz RW, Colton MD, Mitra SS, Messersmith WA. Lentz RW, et al. Mol Cancer Ther. 2021 Jun;20(6):961-974. doi: 10.1158/1535-7163.MCT-21-0041. Epub 2021 Apr 13. Mol Cancer Ther. 2021. PMID: 33850005 Free PMC article. Review.
While immunotherapy has revolutionized the treatment of many types of advanced cancer, most patients still do not derive benefit. The currently available immune checkpoint inhibitors target the adaptive immune system, generating a T-cell antitumor response. ...Here, we com …
While immunotherapy has revolutionized the treatment of many types of advanced cancer, most patients still do not derive benefit. The …
Poliovirus receptor (PVR)-like protein cosignaling network: new opportunities for cancer immunotherapy.
Wu B, Zhong C, Lang Q, Liang Z, Zhang Y, Zhao X, Yu Y, Zhang H, Xu F, Tian Y. Wu B, et al. J Exp Clin Cancer Res. 2021 Aug 25;40(1):267. doi: 10.1186/s13046-021-02068-5. J Exp Clin Cancer Res. 2021. PMID: 34433460 Free PMC article. Review.
Recently, increasing evidence has suggested that this novel cosignaling network axis costimulates and coinhibits NK and T cell activation to eliminate cancer cells after engaging with ligands, and this activity may be effectively targeted for cancer immunotherapy. . …
Recently, increasing evidence has suggested that this novel cosignaling network axis costimulates and coinhibits NK and T cell activation to …
The CD112R/CD112 axis: a breakthrough in cancer immunotherapy.
Zeng T, Cao Y, Jin T, Tian Y, Dai C, Xu F. Zeng T, et al. J Exp Clin Cancer Res. 2021 Sep 10;40(1):285. doi: 10.1186/s13046-021-02053-y. J Exp Clin Cancer Res. 2021. PMID: 34507594 Free PMC article. Review.
It binds to its ligand (CD112 or PVRL2/nectin-2) and inhibits the strength with which T cells and NK cells respond to cancer. Therefore, CD112R is being presented as a new immune checkpoint inhibitor with high potential in cancer immunotherapy. ...In addition, this …
It binds to its ligand (CD112 or PVRL2/nectin-2) and inhibits the strength with which T cells and NK cells respond to cancer. Therefo …
Therapeutic Targeting of Checkpoint Receptors within the DNAM1 Axis.
Alteber Z, Kotturi MF, Whelan S, Ganguly S, Weyl E, Pardoll DM, Hunter J, Ophir E. Alteber Z, et al. Cancer Discov. 2021 May;11(5):1040-1051. doi: 10.1158/2159-8290.CD-20-1248. Epub 2021 Mar 9. Cancer Discov. 2021. PMID: 33687987 Review.
Therapeutic antibodies targeting the CTLA4/PD-1 pathways have revolutionized cancer immunotherapy by eliciting durable remission in patients with cancer. ...The DNAM1 axis is a potent coregulator of innate and adaptive immunity whose other components include the imm …
Therapeutic antibodies targeting the CTLA4/PD-1 pathways have revolutionized cancer immunotherapy by eliciting durable remission in p …
Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors.
Li Y, Zhang Y, Cao G, Zheng X, Sun C, Wei H, Tian Z, Xiao W, Sun R, Sun H. Li Y, et al. J Hematol Oncol. 2021 Jun 26;14(1):100. doi: 10.1186/s13045-021-01112-3. J Hematol Oncol. 2021. PMID: 34174928 Free PMC article.
METHODS: In this study, we used patient paraffin-embedded colon adenocarcinoma sections, various murine tumor models (MC38 colon cancer, MCA205 fibrosarcoma and LLC lung cancer), and human NK cell- or PBMC-reconstituted xenograft models (SW620 colon cancer) t …
METHODS: In this study, we used patient paraffin-embedded colon adenocarcinoma sections, various murine tumor models (MC38 colon cancer …
PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia.
Li J, Whelan S, Kotturi MF, Meyran D, D'Souza C, Hansen K, Liang S, Hunter J, Trapani JA, Neeson PJ. Li J, et al. Haematologica. 2021 Dec 1;106(12):3115-3124. doi: 10.3324/haematol.2020.258574. Haematologica. 2021. PMID: 33147937 Free PMC article.
However, in AML patient bone marrow, NK cell PVRIG expression levels were not increased. To understand how PVRIG blockade might potentially be exploited therapeutically, we investigated the biology of PVRIG and revealed that NK cell activation resulted in red …
However, in AML patient bone marrow, NK cell PVRIG expression levels were not increased. To understand how PVRIG blockade migh …
31 results