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PXMP4 promotes gastric cancer cell epithelial-mesenchymal transition via the PI3K/AKT signaling pathway.
Li W, Dong X, Wan Z, Wang W, Zhang J, Mi Y, Li R, Xu Z, Wang B, Li N, He G. Li W, et al. Mol Biol Rep. 2024 Feb 24;51(1):350. doi: 10.1007/s11033-024-09312-z. Mol Biol Rep. 2024. PMID: 38401002
BACKGROUND: Peroxisomal membrane protein 4 (PXMP4), a member of the peroxisome membrane protein PXMP2/4 family, participates in the progression of several malignant cancers. Nevertheless, the effect of PXMP4 in the development of gastric cancer (GC) is …
BACKGROUND: Peroxisomal membrane protein 4 (PXMP4), a member of the peroxisome membrane protein PXMP2/4 family, participates in the p …
HSD17B4, ACAA1, and PXMP4 in Peroxisome Pathway Are Down-Regulated and Have Clinical Significance in Non-small Cell Lung Cancer.
Zhang X, Yang H, Zhang J, Gao F, Dai L. Zhang X, et al. Front Genet. 2020 Mar 20;11:273. doi: 10.3389/fgene.2020.00273. eCollection 2020. Front Genet. 2020. PMID: 32265992 Free PMC article.
To explore the potential functions and clinical significances of peroxisomes during lung cancer development and progression, we investigated the expressional profiles of peroxisome pathway genes and their correlations with clinical features in non-small cell lung cancer
To explore the potential functions and clinical significances of peroxisomes during lung cancer development and progression, we inves …
High Expression of PXMP4 in Hepatocellular Carcinoma Tissues.
Zhao MM, Awang Z, Jumuddin FAB. Zhao MM, et al. Asian Pac J Cancer Prev. 2024 Feb 1;25(2):603-608. doi: 10.31557/APJCP.2024.25.2.603. Asian Pac J Cancer Prev. 2024. PMID: 38415547 Free PMC article.
METHODS: The expression of PXMP4 mRNA in HCC tissues and corresponding adjacent tissues was detected by Q-PCR, and the expression of PXMP4 protein was detected by Western blot and immunohistochemistry. ...Patients with high expression of PXMP4 had a poor prog …
METHODS: The expression of PXMP4 mRNA in HCC tissues and corresponding adjacent tissues was detected by Q-PCR, and the expression of …
Characterizing the KRAS G12C mutation in metastatic colorectal cancer: a population-based cohort and assessment of expression differences in The Cancer Genome Atlas.
Li M, Keshavarz-Rahaghi F, Ladua G, Swanson L, Speers C, Renouf DJ, Lim HJ, Davies JM, Gill S, Stuart HC, Yip S, Loree JM. Li M, et al. Ther Adv Med Oncol. 2022 Jun 6;14:17588359221097940. doi: 10.1177/17588359221097940. eCollection 2022. Ther Adv Med Oncol. 2022. PMID: 35694189 Free PMC article.
INTRODUCTION: In metastatic colorectal cancer (mCRC), RAS mutations impart inferior survival and resistance to anti-epidermal growth factor receptor (EGFR) antibodies. ...However, eight genes with copy number differences between the G12C and non-G12C RAS mutant groups were …
INTRODUCTION: In metastatic colorectal cancer (mCRC), RAS mutations impart inferior survival and resistance to anti-epidermal growth …
Identification of four methylation-driven genes as candidate biomarkers for monitoring single-walled carbon nanotube-induced malignant transformation of the lung.
Xie D, Luo X. Xie D, et al. Toxicol Appl Pharmacol. 2021 Feb 1;412:115391. doi: 10.1016/j.taap.2020.115391. Epub 2020 Dec 31. Toxicol Appl Pharmacol. 2021. PMID: 33387576
PXMP4 and MET protein levels were also supported in the proteomic analysis of LUAD. Receiver operating characteristic (ROC) curve analysis showed the combination of four genes may be the optimal biomarker for predicting lung cancer, with the area under ROC curve &gt
PXMP4 and MET protein levels were also supported in the proteomic analysis of LUAD. Receiver operating characteristic (ROC) curve ana
Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer.
Zhang X, Wu M, Xiao H, Lee MT, Levin L, Leung YK, Ho SM. Zhang X, et al. Prostate. 2010 May 15;70(7):765-76. doi: 10.1002/pros.21109. Prostate. 2010. PMID: 20054818 Free PMC article.
BACKGROUND: We previously demonstrated that a putative anti-tumor gene, peroxisomal membrane protein 4, 24 kDa (PMP24 or PXMP4), is silenced via DNA methylation of a CpG island in its 5' flanking region (5'-CGI) in prostate cancer (PCa) cells. ...
BACKGROUND: We previously demonstrated that a putative anti-tumor gene, peroxisomal membrane protein 4, 24 kDa (PMP24 or PXMP4), is s …
Comprehensive analysis of location-specific hub genes related to the pathogenesis of colon cancer.
Shi C, Ding K, Li KZ, Long L, Li JL, Hu BL. Shi C, et al. Med Oncol. 2020 Aug 3;37(9):77. doi: 10.1007/s12032-020-01402-9. Med Oncol. 2020. PMID: 32743717
The robust rank aggregation (RRA) method was used to integrate colon cancer microarray datasets and screen differentially expressed gene (DEG) profiles between left- and right-sided colon cancers. ...In total, 905 DEGs were identified by RRA; five gene modules and 1 …
The robust rank aggregation (RRA) method was used to integrate colon cancer microarray datasets and screen differentially expressed g …
PMP24, a gene identified by MSRF, undergoes DNA hypermethylation-associated gene silencing during cancer progression in an LNCaP model.
Wu M, Ho SM. Wu M, et al. Oncogene. 2004 Jan 8;23(1):250-9. doi: 10.1038/sj.onc.1207076. Oncogene. 2004. PMID: 14712230
Transcriptional silencing of antitumor genes via CpG island methylation could be a mechanism mediating prostate cancer (PCa) progression from an androgen-sensitive (AS) to an androgen-insensitive (AI) state. ...
Transcriptional silencing of antitumor genes via CpG island methylation could be a mechanism mediating prostate cancer (PCa) progress …