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141 results

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PYCR1 promotes liver cancer cell growth and metastasis by regulating IRS1 expression through lactylation modification.
Wang H, Xu M, Zhang T, Pan J, Li C, Pan B, Zhou L, Huang Y, Gao C, He M, Xue Y, Ji X, Zhang X, Wang N, Zhou H, Wang Q, Li JZ. Wang H, et al. Clin Transl Med. 2024 Oct;14(10):e70045. doi: 10.1002/ctm2.70045. Clin Transl Med. 2024. PMID: 39422696 Free PMC article.
Transcriptome sequencing was used to search for downstream target genes regulated by PYCR1, and metabolomics was used to identify the downstream metabolites regulated by PYCR1. ...CONCLUSIONS: Our findings identify PYCR1 as a pivotal regulator of LC pr …
Transcriptome sequencing was used to search for downstream target genes regulated by PYCR1, and metabolomics was used to ident …
IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia.
Zheng K, Sha N, Hou G, Leng Z, Zhao Q, Zhang L, He L, Xu M, Jiang Y, Chen T. Zheng K, et al. Nat Commun. 2023 Sep 30;14(1):6117. doi: 10.1038/s41467-023-41658-z. Nat Commun. 2023. PMID: 37777542 Free PMC article.
Here we show that pyrroline-5-carpoxylate reductase-1 (PYCR1), displaying a constant nuclear localization, is phosphorylated by nuclear IGF1R at Tyrosine 135 under hypoxia; this phosphorylation promotes the binding of PYCR1 to ELK4 and thus PYCR1 recruitment …
Here we show that pyrroline-5-carpoxylate reductase-1 (PYCR1), displaying a constant nuclear localization, is phosphorylated by nucle …
Zebrafish Carrying pycr1 Gene Deficiency Display Aging and Multiple Behavioral Abnormalities.
Liang ST, Audira G, Juniardi S, Chen JR, Lai YH, Du ZC, Lin DS, Hsiao CD. Liang ST, et al. Cells. 2019 May 14;8(5):453. doi: 10.3390/cells8050453. Cells. 2019. PMID: 31091804 Free PMC article.
Aging is a natural process that internal gene control and external stimuli mediate. Clinical data pointed out that homozygotic or heterozygotic mutation in the pyrroline-5-carboxylate reductase 1 (PYCR1) gene in humans caused cutis laxa (ARCL) disease, with p …
Aging is a natural process that internal gene control and external stimuli mediate. Clinical data pointed out that homozygotic or het …
Comprehensive proteogenomic characterization of rare kidney tumors.
Li GX, Chen L, Hsiao Y, Mannan R, Zhang Y, Luo J, Petralia F, Cho H, Hosseini N, Leprevost FDV, Calinawan A, Li Y, Anand S, Dagar A, Geffen Y, Kumar-Sinha C, Chugh S, Le A, Ponce S, Guo S, Zhang C, Schnaubelt M, Al Deen NN, Chen F, Caravan W, Houston A, Hopkins A, Newton CJ, Wang X, Polasky DA, Haynes S, Yu F, Jing X, Chen S, Robles AI, Mesri M, Thiagarajan M, An E, Getz GA, Linehan WM, Hostetter G, Jewell SD, Chan DW, Wang P, Omenn GS, Mehra R, Ricketts CJ, Ding L, Chinnaiyan AM, Cieslik MP, Dhanasekaran SM, Zhang H, Nesvizhskii AI; Clinical Proteomic Tumor Analysis Consortium. Li GX, et al. Cell Rep Med. 2024 May 21;5(5):101547. doi: 10.1016/j.xcrm.2024.101547. Epub 2024 May 3. Cell Rep Med. 2024. PMID: 38703764 Free PMC article.
RCCs with high genome instability display overexpression of IGF2BP3 and PYCR1. Integration of single-cell and bulk transcriptome data predicts diverse cell-of-origin and clarifies RCC subtype-specific proteogenomic signatures. ...
RCCs with high genome instability display overexpression of IGF2BP3 and PYCR1. Integration of single-cell and bulk transcriptome data …
Proline restores mitochondrial function and reverses aging hallmarks in senescent cells.
Choudhury D, Rong N, Senthil Kumar HV, Swedick S, Samuel RZ, Mehrotra P, Toftegaard J, Rajabian N, Thiyagarajan R, Podder AK, Wu Y, Shahini S, Seldeen KL, Troen B, Lei P, Andreadis ST. Choudhury D, et al. Cell Rep. 2024 Feb 27;43(2):113738. doi: 10.1016/j.celrep.2024.113738. Epub 2024 Feb 12. Cell Rep. 2024. PMID: 38354087 Free article.
In this study, we report that NANOG restores the expression of key enzymes, PYCR1 and PYCR2, in the proline biosynthesis pathway. Additionally, senescent mesenchymal stem cells manifest severe mitochondrial respiratory impairment, which is alleviated through proline supple …
In this study, we report that NANOG restores the expression of key enzymes, PYCR1 and PYCR2, in the proline biosynthesis pathway. Add …
Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia.
Fang K, Sun M, Leng Z, Chu Y, Zhao Z, Li Z, Zhang Y, Xu A, Zhang Z, Zhang L, Chen T, Xu M. Fang K, et al. J Exp Clin Cancer Res. 2023 Mar 28;42(1):73. doi: 10.1186/s13046-023-02623-2. J Exp Clin Cancer Res. 2023. PMID: 36978187 Free PMC article.
The DDP-resistance role of IGF1R, ASS1, and PYCR1 in OSCC was investigated in vitro and in vivo. RESULTS: Generally, tumour cells exist in a hypoxic microenvironment. ...CONCLUSION: Enhanced expression of ASS1 and PYCR1 via IGF1R pathways rewired arginine and prolin …
The DDP-resistance role of IGF1R, ASS1, and PYCR1 in OSCC was investigated in vitro and in vivo. RESULTS: Generally, tumour cells exi …
Epigenetic modification facilitates proline synthase PYCR1 aberrant expression in gastric cancer.
Xiao S, Yao X, Ye J, Tian X, Yin Z, Zhou L. Xiao S, et al. Biochim Biophys Acta Gene Regul Mech. 2022 Aug;1865(6):194829. doi: 10.1016/j.bbagrm.2022.194829. Epub 2022 May 30. Biochim Biophys Acta Gene Regul Mech. 2022. PMID: 35654390
Copy number alterations in PYCR1 were associated with PYCR1 transcript expression. One CpG island was observed in PYCR1 promoter region, and the hypomethylation occurred at this region could contribute to PYCR1 transcriptional activation in GC. Besides …
Copy number alterations in PYCR1 were associated with PYCR1 transcript expression. One CpG island was observed in PYCR1 …
PYCR in Kidney Renal Papillary Cell Carcinoma: Expression, Prognosis, Gene Regulation Network, and Regulation Targets.
Shao Z, Lu L, Cui Y, Deng L, Xu Q, Liang Q, Lu X, Zhang J, Chen J, Situ Y. Shao Z, et al. Front Biosci (Landmark Ed). 2022 Dec 28;27(12):336. doi: 10.31083/j.fbl2712336. Front Biosci (Landmark Ed). 2022. PMID: 36624948 Free article.
BACKGROUND: Pyrroline-5-carboxylate reductase (PYCR) includes three human genes encoding three isozymes, PYCR1, PYCR2, and PYCR3 (or PYCRL), which facilitate the final step in the conversion of glutamine to proline. ...METHODS: We systematically analyzed the express …
BACKGROUND: Pyrroline-5-carboxylate reductase (PYCR) includes three human genes encoding three isozymes, PYCR1, PYCR2, and PYC …
Hypoxia-induced PYCR1 regulates glycolysis and histone lactylation to promote bladder cancer progression and metastasis via SLC6A14/Glutamine metabolism.
Li Z, Jiang Q, Yang Q, Zhou Y, Wang J. Li Z, et al. Cancer Biol Ther. 2025 Dec;26(1):2546219. doi: 10.1080/15384047.2025.2546219. Epub 2025 Aug 13. Cancer Biol Ther. 2025. PMID: 40808274 Free PMC article.
Here, BC cell lines were cultured under hypoxia to evaluate changes in PYCR1 expression, glycolysis, and lactate production. The xenograft and metastasis models in nude mice were used to validate the role of the PYCR1/H3K18la/SLC6A14 axis in BC progression. GEPIA Bi …
Here, BC cell lines were cultured under hypoxia to evaluate changes in PYCR1 expression, glycolysis, and lactate production. The xeno …
The role of PYCR1 in inhibiting 5-fluorouracil-induced ferroptosis and apoptosis through SLC25A10 in colorectal cancer.
Zhou B, Mai Z, Ye Y, Song Y, Zhang M, Yang X, Xia W, Qiu X. Zhou B, et al. Hum Cell. 2022 Nov;35(6):1900-1911. doi: 10.1007/s13577-022-00775-5. Epub 2022 Sep 14. Hum Cell. 2022. PMID: 36104652
Although PYCR1 is a well-recognized oncogenic gene for malignant tumors, the causal relationship of its expression with malignant growth and cytotoxic chemotherapeutics remains unclear. ...SLC25A10 overexpression reversed the antitumor effects of PYCR1 silenc …
Although PYCR1 is a well-recognized oncogenic gene for malignant tumors, the causal relationship of its expression with malign …
141 results