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2002 1
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2011 4
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114 results

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Page 1
Zebrafish Carrying pycr1 Gene Deficiency Display Aging and Multiple Behavioral Abnormalities.
Liang ST, Audira G, Juniardi S, Chen JR, Lai YH, Du ZC, Lin DS, Hsiao CD. Liang ST, et al. Cells. 2019 May 14;8(5):453. doi: 10.3390/cells8050453. Cells. 2019. PMID: 31091804 Free PMC article.
Aging is a natural process that internal gene control and external stimuli mediate. Clinical data pointed out that homozygotic or heterozygotic mutation in the pyrroline-5-carboxylate reductase 1 (PYCR1) gene in humans caused cutis laxa (ARCL) disease, with p …
Aging is a natural process that internal gene control and external stimuli mediate. Clinical data pointed out that homozygotic or het …
IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia.
Zheng K, Sha N, Hou G, Leng Z, Zhao Q, Zhang L, He L, Xu M, Jiang Y, Chen T. Zheng K, et al. Nat Commun. 2023 Sep 30;14(1):6117. doi: 10.1038/s41467-023-41658-z. Nat Commun. 2023. PMID: 37777542 Free PMC article.
Under hypoxia, ELK4-binding ability and enzymatic activity of PYCR1 are both required for ELK4-Sirt7-mediated transcriptional repression and cell growth maintenance, in which PYCR1-catalyzed NAD(+) production stimulates the deacetylation activity of Sirt7 on H3K18ac …
Under hypoxia, ELK4-binding ability and enzymatic activity of PYCR1 are both required for ELK4-Sirt7-mediated transcriptional repress …
Epigenetic modification facilitates proline synthase PYCR1 aberrant expression in gastric cancer.
Xiao S, Yao X, Ye J, Tian X, Yin Z, Zhou L. Xiao S, et al. Biochim Biophys Acta Gene Regul Mech. 2022 Aug;1865(6):194829. doi: 10.1016/j.bbagrm.2022.194829. Epub 2022 May 30. Biochim Biophys Acta Gene Regul Mech. 2022. PMID: 35654390
Copy number alterations in PYCR1 were associated with PYCR1 transcript expression. One CpG island was observed in PYCR1 promoter region, and the hypomethylation occurred at this region could contribute to PYCR1 transcriptional activation in GC. Besides …
Copy number alterations in PYCR1 were associated with PYCR1 transcript expression. One CpG island was observed in PYCR1 …
PYCR1 promotes the malignant progression of lung cancer through the JAK-STAT3 signaling pathway via PRODH-dependent glutamine synthesize.
Zhang L, Zhao X, Wang E, Yang Y, Hu L, Xu H, Zhang B. Zhang L, et al. Transl Oncol. 2023 Jun;32:101667. doi: 10.1016/j.tranon.2023.101667. Epub 2023 Apr 3. Transl Oncol. 2023. PMID: 37018868 Free PMC article.
Luciferase and CHIP assays were carried out for validate the how PYCR1 regulated PD-L1 expression via STAT3. Xenograft experiment was performed to determine the role of PYCR1 in vivo. ...Finally, we also validated that PYCR1 promoted PD-L1 transcription by el …
Luciferase and CHIP assays were carried out for validate the how PYCR1 regulated PD-L1 expression via STAT3. Xenograft experiment was …
The role of PYCR1 in inhibiting 5-fluorouracil-induced ferroptosis and apoptosis through SLC25A10 in colorectal cancer.
Zhou B, Mai Z, Ye Y, Song Y, Zhang M, Yang X, Xia W, Qiu X. Zhou B, et al. Hum Cell. 2022 Nov;35(6):1900-1911. doi: 10.1007/s13577-022-00775-5. Epub 2022 Sep 14. Hum Cell. 2022. PMID: 36104652
Although PYCR1 is a well-recognized oncogenic gene for malignant tumors, the causal relationship of its expression with malignant growth and cytotoxic chemotherapeutics remains unclear. ...Therefore, PYCR1 is an oncogenic gene that promotes colorectal …
Although PYCR1 is a well-recognized oncogenic gene for malignant tumors, the causal relationship of its expression with malign …
Deciphering the effects of PYCR1 on cell function and its associated mechanism in hepatocellular carcinoma.
Xu Y, Zuo W, Wang X, Zhang Q, Gan X, Tan N, Jia W, Liu J, Li Z, Zhou B, Zhao D, Xie Z, Tan Y, Zheng S, Liu C, Li H, Chen Z, Yang X, Huang Z. Xu Y, et al. Int J Biol Sci. 2021 Jun 1;17(9):2223-2239. doi: 10.7150/ijbs.58026. eCollection 2021. Int J Biol Sci. 2021. PMID: 34239351 Free PMC article.
Overexpression of pyrroline-5-carboxylate reductase 1 (PYCR1) has been associated with the development of certain cancers; however, no studies have specifically examined the role of PYCR1 in hepatocellular carcinoma (HCC). Based on The Cancer Genome Atlas expression …
Overexpression of pyrroline-5-carboxylate reductase 1 (PYCR1) has been associated with the development of certain cancers; however, n …
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome.
Xiao S, Li S, Yuan Z, Zhou L. Xiao S, et al. Ann Transl Med. 2020 Aug;8(15):937. doi: 10.21037/atm-19-4402. Ann Transl Med. 2020. PMID: 32953737 Free PMC article.
Gene set enrichment analysis (GSEA) was further performed to investigate the pathway regulating PYCR1 in GC. ...PI3K inhibition further significantly reduced PYCR1 mRNA and protein expression. Moreover, as PYCR1 is a mitochondrial endomembrane protein, …
Gene set enrichment analysis (GSEA) was further performed to investigate the pathway regulating PYCR1 in GC. ...PI3K inhibitio …
Genetic analysis of Pycr1 and Pycr2 in mice.
Stum MG, Tadenev ALD, Seburn KL, Miers KE, Poon PP, McMaster CR, Robinson C, Kane C, Silva KA, Cliften PF, Sundberg JP, Reinholdt LG, John SWM, Burgess RW. Stum MG, et al. Genetics. 2021 May 17;218(1):iyab048. doi: 10.1093/genetics/iyab048. Genetics. 2021. PMID: 33734376 Free PMC article.
Here, we investigated the genetics of Pycr1 and Pycr2 in mice. A null allele of Pycr1 did not show integument or CL-related phenotypes. ...In mice, Pycr1; Pycr2 double mutants were sub-viable and unhealthy compared to either single mutant, indicating the g …
Here, we investigated the genetics of Pycr1 and Pycr2 in mice. A null allele of Pycr1 did not show integument or CL-related ph …
Increased PYCR1 mRNA predicts poor prognosis in kidney adenocarcinoma: A study based on TCGA database.
Zhang T, Liu Y, Liu W, Li Q, Hou W, Huang Y, Lv P, Meng L, Li Y, Jia Y, Liu X, Zuo Z. Zhang T, et al. Medicine (Baltimore). 2021 Sep 24;100(38):e27145. doi: 10.1097/MD.0000000000027145. Medicine (Baltimore). 2021. PMID: 34559102 Free PMC article.
Additionally, Gene Set Enrichment Analysis was conducted to annotate the biological function of PYCR1 mRNA.Increased PYCR1 mRNA was found in AK tissues. ...The Gene Set Enrichment Analysis suggested that ribosome, proteasome, inhibition of p53 signalin …
Additionally, Gene Set Enrichment Analysis was conducted to annotate the biological function of PYCR1 mRNA.Increased PYCR1 …
The clinical significance of PYCR1 expression in renal cell carcinoma.
Weijin F, Zhibin X, Shengfeng Z, Xiaoli Y, Qijian D, Jiayi L, Qiumei L, Yilong C, Hua M, Deyun L, Jiwen C. Weijin F, et al. Medicine (Baltimore). 2019 Jul;98(28):e16384. doi: 10.1097/MD.0000000000016384. Medicine (Baltimore). 2019. PMID: 31305441 Free PMC article.

Pyrroline-5-carboxylate reductase 1 (PYCR1) is an enzyme involved in cell metabolism and is upregulated in cancer. ...Higher PYCR1 levels were associated with metastasis (P < .01). Kaplan-Meier survival curves indicated that higher PYCR1 expression was cor

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Pyrroline-5-carboxylate reductase 1 (PYCR1) is an enzyme involved in cell metabolism and is upregulated in cancer. ...Higher PYCR1 …
114 results