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1978 1
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Page 1
A Novel Diagnostic Biomarker, PZP, for Detecting Colorectal Cancer in Type 2 Diabetes Mellitus Patients Identified by Serum-Based Mass Spectrometry.
Yang J, Fang W, Wu W, Tian Z, Gao R, Yu L, Chen D, Weng X, Zhu S, Yang C. Yang J, et al. Front Mol Biosci. 2021 Nov 30;8:736272. doi: 10.3389/fmolb.2021.736272. eCollection 2021. Front Mol Biosci. 2021. PMID: 34917649 Free PMC article.
Among these proteins, four proteins showed different expression between the T2DM + CRC and T2DM groups, and PZP exhibited the largest difference. Next, the diagnostic value of serum PZP was validated by ELISA analysis with an AUC of 0.713. Moreover, the combination …
Among these proteins, four proteins showed different expression between the T2DM + CRC and T2DM groups, and PZP exhibited the largest …
Tumor markers for ovarian cancer.
Bhattacharya M, Barlow JJ. Bhattacharya M, et al. Int Adv Surg Oncol. 1979;2:155-76. Int Adv Surg Oncol. 1979. PMID: 95453 Review.
The literature on tumor distinctive markers in ovarian cancer has been reviewed. Various immunological and biochemical approaches have been attempted for the diagnosis and management of patients with ovarian cancer. ...The presence of pregnancy-zone protein (PZP …
The literature on tumor distinctive markers in ovarian cancer has been reviewed. Various immunological and biochemical approaches hav …
The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations.
Klein BJ, Deshpande A, Cox KL, Xuan F, Zandian M, Barbosa K, Khanal S, Tong Q, Zhang Y, Zhang P, Sinha A, Bohlander SK, Shi X, Wen H, Poirier MG, Deshpande AJ, Kutateladze TG. Klein BJ, et al. Nat Commun. 2021 Jul 5;12(1):4130. doi: 10.1038/s41467-021-24418-9. Nat Commun. 2021. PMID: 34226546 Free PMC article.
AF10(PZP) promotes nuclear localization of CALM-AF10 and is required for association with chromatin. Our data indicate that the disruption of AF10(PZP) function in the CALM-AF10 fusion directly leads to transformation, whereas the inclusion of AF10(PZP) downr …
AF10(PZP) promotes nuclear localization of CALM-AF10 and is required for association with chromatin. Our data indicate that the disru …
Genetic ablation of pregnancy zone protein promotes breast cancer progression by activating TGF-beta/SMAD signaling.
Kumar R, Kuligina E, Sokolenko A, Siddiqui Q, Gardi N, Gupta S, Varma AK, Hasan SK. Kumar R, et al. Breast Cancer Res Treat. 2021 Jan;185(2):317-330. doi: 10.1007/s10549-020-05958-y. Epub 2020 Oct 15. Breast Cancer Res Treat. 2021. PMID: 33057846

The PZP knockout significantly promoted breast cancer cell migration (p < 0.01) in vitro. ...CONCLUSION: Taken together, our results suggest that genetic ablation of PZP results in tumor progression and low expression of PZP is associated with poor

…

The PZP knockout significantly promoted breast cancer cell migration (p < 0.01) in vitro. ...CONCLUSION: Taken together, ou

…
Structural and biophysical characterization of the nucleosome-binding PZP domain.
Klein BJ, Cox KL, Jang SM, Singh RK, Côté J, Poirier MG, Kutateladze TG. Klein BJ, et al. STAR Protoc. 2021 Apr 19;2(2):100479. doi: 10.1016/j.xpro.2021.100479. eCollection 2021 Jun 18. STAR Protoc. 2021. PMID: 33982013 Free PMC article.
The core subunit of the MORF acetyltransferase complex BRPF1 contains a unique combination of zinc fingers, including a plant homeodomain (PHD) finger followed by a zinc knuckle and another PHD finger, which together form a PZP domain (BRPF1(PZP)). BRPF1(PZP) …
The core subunit of the MORF acetyltransferase complex BRPF1 contains a unique combination of zinc fingers, including a plant homeodomain (P …
Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin.
Klein BJ, Cox KL, Jang SM, Côté J, Poirier MG, Kutateladze TG. Klein BJ, et al. Structure. 2020 Jan 7;28(1):105-110.e3. doi: 10.1016/j.str.2019.10.014. Epub 2019 Nov 8. Structure. 2020. PMID: 31711755 Free PMC article.
In this study, we report the crystal structure of BRPF1(PZP) bound to the H3 tail and characterize the role of the bipartite interaction in the engagement of BRPF1(PZP) with the nucleosome core particle (NCP). ...Our findings suggest that functionally active BRPF1( …
In this study, we report the crystal structure of BRPF1(PZP) bound to the H3 tail and characterize the role of the bipartite interact …
The Pregnancy Zone Protein (PZP) is significantly downregulated in the placenta of preeclampsia and HELLP syndrome patients.
Löb S, Vattai A, Kuhn C, Mittelberger J, Herbert SL, Wöckel A, Schmoeckel E, Mahner S, Jeschke U. Löb S, et al. J Reprod Immunol. 2022 Sep;153:103663. doi: 10.1016/j.jri.2022.103663. Epub 2022 Jul 9. J Reprod Immunol. 2022. PMID: 35843132
Little is known about the role of EFTUD2 and PZP in disorders of late pregnancy like preeclampsia, HELLP syndrome and intrauterine growth restriction (IUGR). ...Our results indicate that PZP and EFTUD2 might be involved in the development of placental dysfunction in …
Little is known about the role of EFTUD2 and PZP in disorders of late pregnancy like preeclampsia, HELLP syndrome and intrauterine gr …
Hypermethylation of the PZP gene is associated with hepatocellular carcinoma cell proliferation, invasion and migration.
Wu M, Lan H, Ye Z, Wang Y. Wu M, et al. FEBS Open Bio. 2021 Mar;11(3):826-832. doi: 10.1002/2211-5463.13093. Epub 2021 Feb 21. FEBS Open Bio. 2021. PMID: 33471436 Free PMC article.
The gene encoding PZP is hypermethylated and expressed at low levels in hepatocellular carcinoma (HCC) tissue and cells, but the function of PZP in HCC cells remains unclear. Here, we analyzed DNA methylation and mRNA expression of HCC in The Cancer Genome At …
The gene encoding PZP is hypermethylated and expressed at low levels in hepatocellular carcinoma (HCC) tissue and cells, but the func …
The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.
Chen S, Yang Z, Wilkinson AW, Deshpande AJ, Sidoli S, Krajewski K, Strahl BD, Garcia BA, Armstrong SA, Patel DJ, Gozani O. Chen S, et al. Mol Cell. 2015 Oct 15;60(2):319-27. doi: 10.1016/j.molcel.2015.08.019. Epub 2015 Oct 1. Mol Cell. 2015. PMID: 26439302 Free PMC article.
In cells, PZP recognition of H3 is required for H3K79 dimethylation, expression of DOT1L-target genes, and proliferation of DOT1L-addicted leukemic cells. Together, our results uncover a pivotal role for H3K27-via readout by the AF10 PZP domain-in regulating the …
In cells, PZP recognition of H3 is required for H3K79 dimethylation, expression of DOT1L-target genes, and proliferation of DOT1L-add …
52 results