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67 results

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PAIP1 is a novel oncogene in human hepatocellular carcinoma.
Zhang N, Chen X. Zhang N, et al. Discov Oncol. 2022 Nov 27;13(1):132. doi: 10.1007/s12672-022-00530-0. Discov Oncol. 2022. PMID: 36436074 Free PMC article.
Moreover, PAIP1 knockdown significantly reduces tumorigenesis in a murine transplantation model. Bioinformatics and immunoblotting analysis reveal that PAIP1 knockdown dysregulates cyclin D pathway-related proteins. CONCLUSION: PAIP1 plays an oncogenic role i …
Moreover, PAIP1 knockdown significantly reduces tumorigenesis in a murine transplantation model. Bioinformatics and immunoblotting an …
PAIP1 regulates expression of immune and inflammatory response associated genes at transcript level in liver cancer cell.
Zheng J, Fan W, Zhang X, Quan W, Wu Y, Shu M, Chen M, Liang M. Zheng J, et al. PeerJ. 2023 Apr 21;11:e15070. doi: 10.7717/peerj.15070. eCollection 2023. PeerJ. 2023. PMID: 37101794 Free PMC article.
Poly(A) binding protein interacting protein 1 (PAIP1) is a translation regulator and also regulate the decay of mRNA. PAIP1 has also been reported to be a marker of increased invasive potential of liver cancer. ...
Poly(A) binding protein interacting protein 1 (PAIP1) is a translation regulator and also regulate the decay of mRNA. PAIP1 ha …
Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.
Li N, Piao J, Wang X, Kim KY, Bae JY, Ren X, Lin Z. Li N, et al. Cancer Res Treat. 2019 Oct;51(4):1653-1665. doi: 10.4143/crt.2018.544. Epub 2019 Apr 19. Cancer Res Treat. 2019. PMID: 31010277 Free PMC article.
In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression. RESULTS: Paip1 was found to be up-regulated in CC, which was linked with shorter survival. ...The in vivo tumor model confirmed the pro-tumor role of Paip1 in CC growth. …
In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression. RESULTS: Paip1 was found to be up-re …
Loss of Paip1 causes translation reduction and induces apoptotic cell death through ISR activation and Xrp1.
Xue M, Cong F, Zheng W, Xu R, Liu X, Bao H, Sung YY, Xi Y, He F, Ma J, Yang X, Ge W. Xue M, et al. Cell Death Discov. 2023 Aug 5;9(1):288. doi: 10.1038/s41420-023-01587-8. Cell Death Discov. 2023. PMID: 37543696 Free PMC article.
Regulation of protein translation initiation is tightly associated with cell growth and survival. Here, we identify Paip1, the Drosophila homolog of the translation initiation factor PAIP1, and analyze its role during development. Through genetic analysis, we find t …
Regulation of protein translation initiation is tightly associated with cell growth and survival. Here, we identify Paip1, the Drosop …
Role of Paip1 on angiogenesis and invasion in pancreatic cancer.
Guan H, Li N, Wang X, Shan X, Li Z, Lin Z. Guan H, et al. Exp Cell Res. 2019 Mar 15;376(2):198-209. doi: 10.1016/j.yexcr.2019.01.017. Epub 2019 Feb 4. Exp Cell Res. 2019. PMID: 30731074
In our present study, we found that Paip1 was over-expressed in human PC tissues. As well as poor survival, the over-expression of Paip1 was associated with lymph node (LN) metastasis of the PC samples analyzed. Paip1 silencing inhibits PC cell proliferation, …
In our present study, we found that Paip1 was over-expressed in human PC tissues. As well as poor survival, the over-expression of …
Upregulation of PAIP1 promotes the gallbladder tumorigenesis through regulating PLK1 level.
Bi J, Ma H, Liu Y, Huang A, Xiao Y, Shu WJ, Du H, Zhang T. Bi J, et al. Ann Transl Med. 2021 Jun;9(12):991. doi: 10.21037/atm-21-2417. Ann Transl Med. 2021. PMID: 34277791 Free PMC article.
PAIP1 interacted with PLK1, and rescue of PAIP1 could recover PLK1 protein level and inhibit apoptosis. ...Since upregulated PAIP1 expression is positively associated with GBC, PAIP1 may act as a clinical prognostic biomarker of GBC....
PAIP1 interacted with PLK1, and rescue of PAIP1 could recover PLK1 protein level and inhibit apoptosis. ...Since upregulated …
Paip1 predicts poor prognosis and promotes tumor progression through AKT/GSK-3beta pathway in lung adenocarcinoma.
Wang Y, Piao J, Wang Q, Cui X, Meng Z, Jin T, Lin Z. Wang Y, et al. Hum Pathol. 2019 Apr;86:233-242. doi: 10.1016/j.humpath.2018.11.017. Epub 2018 Nov 26. Hum Pathol. 2019. PMID: 30496797
Paip1 protein was upregulated in 77.6% (45/58) LADC tissues compared with adjacent normal lung tissues. ...Furthermore, Paip1 regulated AKT/GSK-3beta oncogenic signaling pathways. In conclusions, Paip1 expression is frequently upregulated in LADC, and its ove …
Paip1 protein was upregulated in 77.6% (45/58) LADC tissues compared with adjacent normal lung tissues. ...Furthermore, Paip1 …
Effect of PAIP1 on the metastatic potential and prognostic significance in oral squamous cell carcinoma.
Swarup N, Hong KO, Chawla K, Choi SJ, Shin JA, Oh KY, Yoon HJ, Lee JI, Cho SD, Hong SD. Swarup N, et al. Int J Oral Sci. 2022 Feb 14;14(1):9. doi: 10.1038/s41368-022-00162-8. Int J Oral Sci. 2022. PMID: 35153296 Free PMC article.
Here, we used the data available from Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), and Clinical Proteomic Tumor Analysis Consortium (CPTAC) to analyze PAIP1 expression in oral cancer. The publicly available data suggests that PAIP1 mRNA and protein …
Here, we used the data available from Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), and Clinical Proteomic Tumor Analysis C …
Paip1 affects breast cancer cell growth and represents a novel prognostic biomarker.
Piao J, Chen L, Jin T, Xu M, Quan C, Lin Z. Piao J, et al. Hum Pathol. 2018 Mar;73:33-40. doi: 10.1016/j.humpath.2017.10.037. Epub 2017 Dec 16. Hum Pathol. 2018. PMID: 29258905
Polyadenylate-binding protein-interacting protein 1 (Paip1) regulates translational initiation. Increasing evidence suggests that Paip1 plays important roles in cancer development and progression. ...Paip1 was expressed mainly in the cytoplasm of cancer cells …
Polyadenylate-binding protein-interacting protein 1 (Paip1) regulates translational initiation. Increasing evidence suggests that …
High Paip1 Expression as a Potential Prognostic Marker in Hepatocellular Carcinoma.
Kim H, Jung W, Kim A, Kim HK, Kim BH. Kim H, et al. In Vivo. 2020 Sep-Oct;34(5):2491-2497. doi: 10.21873/invivo.12065. In Vivo. 2020. PMID: 32871777 Free PMC article.
The prognostic value of Paip1 and eIF4A1 was evaluated by the Kaplan-Meier plotter. RESULTS: Among 173 HCC patients, 28 (16.1%) and 46 (26.6%) belonged in the Paip1 and eIF4A1 high-expression groups. ...CONCLUSION: Paip1 expression has a potential prognostic …
The prognostic value of Paip1 and eIF4A1 was evaluated by the Kaplan-Meier plotter. RESULTS: Among 173 HCC patients, 28 (16.1%) and 4 …
67 results