Palfi S - Search Results

1

Dopamine gene therapy for Parkinson's disease in a nonhuman primate without associated dyskinesia.

Jarraya B, Boulet S, Ralph GS, Jan C, Bonvento G, Azzouz M, Miskin JE, Shin M, Delzescaux T, Drouot X, Hérard AS, Day DM, Brouillet E, Kingsman SM, Hantraye P, Mitrophanous KA, Mazarakis ND, Palfi S. Jarraya B, et al. Among authors: palfi s. Sci Transl Med. 2009 Oct 14;1(2):2ra4. doi: 10.1126/scitranslmed.3000130. Sci Transl Med. 2009. PMID: 20368163

2

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.

Palfi S, Gurruchaga JM, Ralph GS, Lepetit H, Lavisse S, Buttery PC, Watts C, Miskin J, Kelleher M, Deeley S, Iwamuro H, Lefaucheur JP, Thiriez C, Fenelon G, Lucas C, Brugières P, Gabriel I, Abhay K, Drouot X, Tani N, Kas A, Ghaleh B, Le Corvoisier P, Dolphin P, Breen DP, Mason S, Guzman NV, Mazarakis ND, Radcliffe PA, Harrop R, Kingsman SM, Rascol O, Naylor S, Barker RA, Hantraye P, Remy P, Cesaro P, Mitrophanous KA. Palfi S, et al. Lancet. 2014 Mar 29;383(9923):1138-46. doi: 10.1016/S0140-6736(13)61939-X. Epub 2014 Jan 10. Lancet. 2014. PMID: 24412048 Clinical Trial.

3

Long-Term Follow-Up of a Phase I/II Study of ProSavin, a Lentiviral Vector Gene Therapy for Parkinson's Disease.

Palfi S, Gurruchaga JM, Lepetit H, Howard K, Ralph GS, Mason S, Gouello G, Domenech P, Buttery PC, Hantraye P, Tuckwell NJ, Barker RA, Mitrophanous KA. Palfi S, et al. Hum Gene Ther Clin Dev. 2018 Sep;29(3):148-155. doi: 10.1089/humc.2018.081. Hum Gene Ther Clin Dev. 2018. PMID: 30156440 Free PMC article. Clinical Trial.

4

Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation.

Drouot X, Oshino S, Jarraya B, Besret L, Kishima H, Remy P, Dauguet J, Lefaucheur JP, Dollé F, Condé F, Bottlaender M, Peschanski M, Kéravel Y, Hantraye P, Palfi S. Drouot X, et al. Among authors: palfi s. Neuron. 2004 Dec 2;44(5):769-78. doi: 10.1016/j.neuron.2004.11.023. Neuron. 2004. PMID: 15572109 Free article.

5

Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates.

Palfi S, Brouillet E, Jarraya B, Bloch J, Jan C, Shin M, Condé F, Li XJ, Aebischer P, Hantraye P, Déglon N. Palfi S, et al. Mol Ther. 2007 Aug;15(8):1444-51. doi: 10.1038/sj.mt.6300185. Epub 2007 May 1. Mol Ther. 2007. PMID: 17505477 Free article.

6

Chronic systemic treatment with a high-dose proteasome inhibitor in mice produces akinesia unrelated to nigrostriatal degeneration.

Shin M, Jan C, Jacquard C, Jarraya B, Callebert J, Launay JM, Hantraye P, Remy P, Palfi S, Brouillet E. Shin M, et al. Among authors: palfi s. Neurobiol Aging. 2011 Nov;32(11):2100-2. doi: 10.1016/j.neurobiolaging.2009.11.015. Epub 2009 Dec 16. Neurobiol Aging. 2011. PMID: 20018410

7

Optimizing Transgene Configuration and Protein Fusions to Maximize Dopamine Production for the Gene Therapy of Parkinson's Disease.

Stewart HJ, Ralph GS, Fong-Wong L, Strickland I, McCloskey L, Barnes L, Blount I, Wells O, Truran CJ, Kingsman AJ, Palfi S, Mitrophanous KA. Stewart HJ, et al. Among authors: palfi s. Hum Gene Ther Clin Dev. 2016 Sep;27(3):100-10. doi: 10.1089/humc.2016.056. Epub 2016 Jul 28. Hum Gene Ther Clin Dev. 2016. PMID: 27470285

8

Gene Therapy for Parkinson's Disease: Preclinical Evaluation of Optimally Configured TH:CH1 Fusion for Maximal Dopamine Synthesis.

Badin RA, Binley K, Van Camp N, Jan C, Gourlay J, Robert C, Gipchtein P, Fayard A, Stewart H, Ralph GS, Lad Y, Kelleher M, Loader J, Hosomi K, Palfi S, Mitrophanous KA, Hantraye P. Badin RA, et al. Among authors: palfi s. Mol Ther Methods Clin Dev. 2019 Jul 16;14:206-216. doi: 10.1016/j.omtm.2019.07.002. eCollection 2019 Sep 13. Mol Ther Methods Clin Dev. 2019. PMID: 31406701 Free PMC article.

9

Optogenetic Tractography for anatomo-functional characterization of cortico-subcortical neural circuits in non-human primates.

Senova S, Poupon C, Dauguet J, Stewart HJ, Dugué GP, Jan C, Hosomi K, Ralph GS, Barnes L, Drouot X, Pouzat C, Mangin JF, Pain F, Doignon I, Aron-Badin R, Brouillet E, Boyden ES, Mitrophanous KA, Hantraye P, Palfi S. Senova S, et al. Among authors: palfi s. Sci Rep. 2018 Feb 20;8(1):3362. doi: 10.1038/s41598-018-21486-8. Sci Rep. 2018. PMID: 29463867 Free PMC article.

10

Huntington's disease: genetics lends a hand.

Palfi S, Jarraya B. Palfi S, et al. Nature. 2008 Jun 12;453(7197):863-4. doi: 10.1038/nature06365. Nature. 2008. PMID: 18488017 No abstract available.

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