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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2008 1
2010 1
2013 1
2014 1
2016 3
2017 3
2018 4
2019 3
2020 8
2021 8
2022 4
2023 10
2024 4

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48 results

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Page 1
Management of Brain Metastases in Non-Small-Cell Lung Cancer.
Ernani V, Stinchcombe TE. Ernani V, et al. J Oncol Pract. 2019 Nov;15(11):563-570. doi: 10.1200/JOP.19.00357. J Oncol Pract. 2019. PMID: 31715122 Free PMC article. Review.
The treatments for BMs have become complex with the discovery of targetable molecular drivers and the development of an astonishing number of tyrosine kinase inhibitors. ...
The treatments for BMs have become complex with the discovery of targetable molecular drivers and the development of an astonishing n …
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.
Roe JS, Hwang CI, Somerville TDD, Milazzo JP, Lee EJ, Da Silva B, Maiorino L, Tiriac H, Young CM, Miyabayashi K, Filippini D, Creighton B, Burkhart RA, Buscaglia JM, Kim EJ, Grem JL, Lazenby AJ, Grunkemeyer JA, Hollingsworth MA, Grandgenett PM, Egeblad M, Park Y, Tuveson DA, Vakoc CR. Roe JS, et al. Cell. 2017 Aug 24;170(5):875-888.e20. doi: 10.1016/j.cell.2017.07.007. Epub 2017 Jul 27. Cell. 2017. PMID: 28757253 Free PMC article.
This approach revealed that the metastatic transition is accompanied by massive and recurrent alterations in enhancer activity. We implicate the pioneer factor FOXA1 as a driver of enhancer activation in this system, a mechanism that renders PDA cells more invasive and les …
This approach revealed that the metastatic transition is accompanied by massive and recurrent alterations in enhancer activity. We implicate …
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.
Tiriac H, Belleau P, Engle DD, Plenker D, Deschênes A, Somerville TDD, Froeling FEM, Burkhart RA, Denroche RE, Jang GH, Miyabayashi K, Young CM, Patel H, Ma M, LaComb JF, Palmaira RLD, Javed AA, Huynh JC, Johnson M, Arora K, Robine N, Shah M, Sanghvi R, Goetz AB, Lowder CY, Martello L, Driehuis E, LeComte N, Askan G, Iacobuzio-Donahue CA, Clevers H, Wood LD, Hruban RH, Thompson E, Aguirre AJ, Wolpin BM, Sasson A, Kim J, Wu M, Bucobo JC, Allen P, Sejpal DV, Nealon W, Sullivan JD, Winter JM, Gimotty PA, Grem JL, DiMaio DJ, Buscaglia JM, Grandgenett PM, Brody JR, Hollingsworth MA, O'Kane GM, Notta F, Kim E, Crawford JM, Devoe C, Ocean A, Wolfgang CL, Yu KH, Li E, Vakoc CR, Hubert B, Fischer SE, Wilson JM, Moffitt R, Knox J, Krasnitz A, Gallinger S, Tuveson DA. Tiriac H, et al. Cancer Discov. 2018 Sep;8(9):1112-1129. doi: 10.1158/2159-8290.CD-18-0349. Epub 2018 May 31. Cancer Discov. 2018. PMID: 29853643 Free PMC article.
We generated a pancreatic cancer patient-derived organoid (PDO) library that recapitulates the mutational spectrum and transcriptional subtypes of primary pancreatic cancer. New driver oncogenes were nominated and transcriptomic analyses revealed unique clusters. ...
We generated a pancreatic cancer patient-derived organoid (PDO) library that recapitulates the mutational spectrum and transcriptional subty …
Novel Treatment Paradigms in Acute Myeloid Leukemia.
Khanal N, Upadhyay Banskota S, Bhatt VR. Khanal N, et al. Clin Pharmacol Ther. 2020 Sep;108(3):506-514. doi: 10.1002/cpt.1962. Epub 2020 Aug 11. Clin Pharmacol Ther. 2020. PMID: 32572947 Free PMC article. Review.
Acute myeloid leukemia (AML) is a heterogeneous disease marked by the presence of several driver mutations and molecular subgroups even in a single patient. ...
Acute myeloid leukemia (AML) is a heterogeneous disease marked by the presence of several driver mutations and molecular subgroups ev …
Elevated PAF1-RAD52 axis confers chemoresistance to human cancers.
Rauth S, Ganguly K, Atri P, Parte S, Nimmakayala RK, Varadharaj V, Nallasamy P, Vengoji R, Ogunleye AO, Lakshmanan I, Chirravuri R, Bessho M, Cox JL, Foster JM, Talmon GA, Bessho T, Ganti AK, Batra SK, Ponnusamy MP. Rauth S, et al. Cell Rep. 2023 Feb 28;42(2):112043. doi: 10.1016/j.celrep.2023.112043. Epub 2023 Jan 28. Cell Rep. 2023. PMID: 36709426 Free PMC article.
Here, we identify RNA polymerase II-associated factor 1 (PAF1) as a common driver of cisplatin and gemcitabine resistance in human cancers (ovarian, lung, and pancreas). ...
Here, we identify RNA polymerase II-associated factor 1 (PAF1) as a common driver of cisplatin and gemcitabine resistance in human ca …
Beyond the horizon: Neutrophils leading the way in the evolution of immunotherapy.
Rajgopal S, Nakano K, Cook LM. Rajgopal S, et al. Cancer Med. 2023 Dec;12(24):21885-21904. doi: 10.1002/cam4.6761. Epub 2023 Dec 7. Cancer Med. 2023. PMID: 38062888 Free PMC article. Review.
However, the development of predominantly T cell-targeted immunotherapy approaches, such as immune checkpoint inhibition, also brought about an accumulation of evidence demonstrating other immune cell drivers of tumor progression, such as innate immune cells and notably, n …
However, the development of predominantly T cell-targeted immunotherapy approaches, such as immune checkpoint inhibition, also brought about …
Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings.
Hicks EM, Seah C, Cote A, Marchese S, Brennand KJ, Nestler EJ, Girgenti MJ, Huckins LM. Hicks EM, et al. Transl Psychiatry. 2023 Apr 19;13(1):129. doi: 10.1038/s41398-023-02412-7. Transl Psychiatry. 2023. PMID: 37076454 Free PMC article. Review.
Postmortem brain gene expression data are uniquely valuable resources for identifying this signature and key genomic drivers in human depression; however, the scarcity of brain tissue limits our capacity to observe the dynamic transcriptional landscape of MDD. ...
Postmortem brain gene expression data are uniquely valuable resources for identifying this signature and key genomic drivers in human …
Genome Instability in Multiple Myeloma: Facts and Factors.
Aksenova AY, Zhuk AS, Lada AG, Zotova IV, Stepchenkova EI, Kostroma II, Gritsaev SV, Pavlov YI. Aksenova AY, et al. Cancers (Basel). 2021 Nov 26;13(23):5949. doi: 10.3390/cancers13235949. Cancers (Basel). 2021. PMID: 34885058 Free PMC article. Review.
Chemotherapeutic agents used to treat MM add another level of complexity because many of them exacerbate genome instability. Genome abnormalities are driver events and deciphering their mechanisms will help understand the causes of MM and play a pivotal role in developing …
Chemotherapeutic agents used to treat MM add another level of complexity because many of them exacerbate genome instability. Genome abnormal …
Immunotherapy in treatment naïve advanced non-small cell lung cancer.
Ernani V, Ganti AK. Ernani V, et al. J Thorac Dis. 2018 Feb;10(Suppl 3):S412-S421. doi: 10.21037/jtd.2017.12.94. J Thorac Dis. 2018. PMID: 29593887 Free PMC article. Review.
Despite remarkable advances in targeted therapy for a subset of patients harboring a driver mutation, the prognosis in the majority of the lung cancer population have not changed significantly. ...
Despite remarkable advances in targeted therapy for a subset of patients harboring a driver mutation, the prognosis in the majority o …
Editorial for the IJMS Special Issue on Molecular Pathogenesis and Molecular Therapy of Lymphoid Malignancies.
Eiken AP, El-Gamal D. Eiken AP, et al. Int J Mol Sci. 2023 Dec 31;25(1):557. doi: 10.3390/ijms25010557. Int J Mol Sci. 2023. PMID: 38203728 Free PMC article.
In the era of targeted therapies, researchers have aimed to uncover the molecular drivers of malignant pathogenesis in lymphoid malignancies in an endeavor to develop effective therapeutic strategies [...]....
In the era of targeted therapies, researchers have aimed to uncover the molecular drivers of malignant pathogenesis in lymphoid malig …
48 results