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Reassessing the melatonin pharmacophore--enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue.
Rivara S, Diamantini G, Di Giacomo B, Lamba D, Gatti G, Lucini V, Pannacci M, Mor M, Spadoni G, Tarzia G. Rivara S, et al. Among authors: pannacci m. Bioorg Med Chem. 2006 May 15;14(10):3383-91. doi: 10.1016/j.bmc.2005.12.053. Epub 2006 Jan 20. Bioorg Med Chem. 2006. PMID: 16431121
Synthesis and biological activity of new melatonin dimeric derivatives.
Di Giacomo B, Bedini A, Spadoni G, Tarzia G, Fraschini F, Pannacci M, Lucini V. Di Giacomo B, et al. Among authors: pannacci m. Bioorg Med Chem. 2007 Jul 1;15(13):4643-50. doi: 10.1016/j.bmc.2007.03.080. Epub 2007 Mar 30. Bioorg Med Chem. 2007. PMID: 17481904
Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.
Rivara S, Mor M, Silva C, Zuliani V, Vacondio F, Spadoni G, Bedini A, Tarzia G, Lucini V, Pannacci M, Fraschini F, Plazzi PV. Rivara S, et al. Among authors: pannacci m. J Med Chem. 2003 Apr 10;46(8):1429-39. doi: 10.1021/jm020982d. J Med Chem. 2003. PMID: 12672242
Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study.
Spadoni G, Balsamini C, Diamantini G, Di Giacomo B, Tarzia G, Mor M, Plazzi PV, Rivara S, Lucini V, Nonno R, Pannacci M, Fraschini F, Stankov BM. Spadoni G, et al. Among authors: pannacci m. J Med Chem. 1997 Jun 20;40(13):1990-2002. doi: 10.1021/jm960651z. J Med Chem. 1997. PMID: 9207940
38 results