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The PAPSS1 gene is a modulator of response to cisplatin by regulating estrogen receptor alpha signaling activity in ovarian cancer cells.
Sun L, Ji WX, Li Y, Li ZL, Duan CC, Xia BR, Xiao L. Sun L, et al. J Ovarian Res. 2023 Sep 8;16(1):187. doi: 10.1186/s13048-023-01262-7. J Ovarian Res. 2023. PMID: 37684671 Free PMC article.
Expression of PAPSS1 was negatively correlated with estrogen receptor alpha (ERalpha) in EOC. ...PAPSS1 may be exploited as a cisplatin-sensitizing therapeutic target....
Expression of PAPSS1 was negatively correlated with estrogen receptor alpha (ERalpha) in EOC. ...PAPSS1 may be exploited as a …
In Vivo Validation of PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target.
Leung AWY, Veinotte CJ, Melong N, Oh MH, Chen K, Enfield KSS, Backstrom I, Warburton C, Yapp D, Berman JN, Bally MB, Lockwood WW. Leung AWY, et al. Clin Cancer Res. 2017 Nov 1;23(21):6555-6566. doi: 10.1158/1078-0432.CCR-17-0700. Epub 2017 Aug 8. Clin Cancer Res. 2017. PMID: 28790117
Here, we explored the clinical relevance of PAPSS1 and further investigated it as a therapeutic target in preclinical model systems.Experimental Design: PAPSS1 expression and cisplatin IC(50) values were assessed in 52 lung adenocarcinoma cell lines. ...Clinical dat …
Here, we explored the clinical relevance of PAPSS1 and further investigated it as a therapeutic target in preclinical model systems.E …
Genome-wide CRISPR screen for HSV-1 host factors reveals PAPSS1 contributes to heparan sulfate synthesis.
Suzuki T, Sato Y, Okuno Y, Goshima F, Mikami T, Umeda M, Murata T, Watanabe T, Watashi K, Wakita T, Kitagawa H, Kimura H. Suzuki T, et al. Commun Biol. 2022 Jul 19;5(1):694. doi: 10.1038/s42003-022-03581-9. Commun Biol. 2022. PMID: 35854076 Free PMC article.
Along with several already known host factors, we identified 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1) as a host factor for HSV-1 infection. The KO of PAPSS1 in HAP1 cells reduced heparan sulfate (HepS) expression, consequently diminishing the bindin …
Along with several already known host factors, we identified 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1) as a host fact …
Correlation of 3'-phosphoadenosine-5'-phosphosulfate synthase 1 (PAPSS1) expression with clinical parameters and prognosis in esophageal squamous cell carcinoma.
Zhu X, Zhu P, Chen X, Zhang L, Wu C, Zhang H, Shen X, Qi Y, Chen M, Wang S, Yi X. Zhu X, et al. Histol Histopathol. 2023 Nov;38(11):1327-1335. doi: 10.14670/HH-18-590. Epub 2023 Jan 23. Histol Histopathol. 2023. PMID: 36734141
Nevertheless, the role of PAPSS1 in esophageal squamous cell carcinoma (ESCC) is poorly understood. ...At the same time, the expression levels of Bcl2, Ki67 and Snail were all upregulated by siRNA-PAPSS1. PAPSS1, however, was suppressed. CONCLUSIONS: PAPSS …
Nevertheless, the role of PAPSS1 in esophageal squamous cell carcinoma (ESCC) is poorly understood. ...At the same time, the expressi …
Steroid disulfates - Sulfation double trouble.
Lightning TA, Gesteira TF, Mueller JW. Lightning TA, et al. Mol Cell Endocrinol. 2021 Mar 15;524:111161. doi: 10.1016/j.mce.2021.111161. Epub 2021 Jan 14. Mol Cell Endocrinol. 2021. PMID: 33453296 Review.
Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiency.
Venkatachalam KV. Venkatachalam KV. IUBMB Life. 2003 Jan;55(1):1-11. doi: 10.1080/1521654031000072148. IUBMB Life. 2003. PMID: 12716056 Free article. Review.
In humans there are two major isoforms PAPSS1 and PAPSS2. In brain and skin PAPSS1 is the major expressed isoform, whereas in liver, cartilage and adrenal glands PAPSS2 isoform expression predominates and in various other tissues the proportions of the isoform expre …
In humans there are two major isoforms PAPSS1 and PAPSS2. In brain and skin PAPSS1 is the major expressed isoform, whereas in …
3'-Phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1) knockdown sensitizes non-small cell lung cancer cells to DNA damaging agents.
Leung AW, Dragowska WH, Ricaurte D, Kwok B, Mathew V, Roosendaal J, Ahluwalia A, Warburton C, Laskin JJ, Stirling PC, Qadir MA, Bally MB. Leung AW, et al. Oncotarget. 2015 Jul 10;6(19):17161-77. doi: 10.18632/oncotarget.3635. Oncotarget. 2015. PMID: 26220590 Free PMC article.
PAPSS1 knockdown in combination with low-dose (IC10) cisplatin reduces clonogenicity of NSCLC cells by 98.7% (p < 0.001), increases DNA damage, and induces G1/S phase cell cycle arrest and apoptosis. PAPSS1 silencing also sensitized NSCLC cells to other DNA cross …
PAPSS1 knockdown in combination with low-dose (IC10) cisplatin reduces clonogenicity of NSCLC cells by 98.7% (p < 0.001), increase …
Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization.
Xu ZH, Otterness DM, Freimuth RR, Carlini EJ, Wood TC, Mitchell S, Moon E, Kim UJ, Xu JP, Siciliano MJ, Weinshilboum RM. Xu ZH, et al. Biochem Biophys Res Commun. 2000 Feb 16;268(2):437-44. doi: 10.1006/bbrc.2000.2123. Biochem Biophys Res Commun. 2000. PMID: 10679223
PAPS is synthesized from ATP and inorganic sulfate by PAPS synthetase (PAPSS). Two separate PAPSS cDNAs, PAPSS1 and PAPSS2, have been identified in human tissues. We have cloned and characterized the genes for human PAPSS1 and PAPSS2 to make it possible to study the …
PAPS is synthesized from ATP and inorganic sulfate by PAPS synthetase (PAPSS). Two separate PAPSS cDNAs, PAPSS1 and PAPSS2, have been …
Evidence for association with hepatocellular carcinoma at the PAPSS1 locus on chromosome 4q25 in a family-based study.
Shih WL, Yu MW, Chen PJ, Wu TW, Lin CL, Liu CJ, Lin SM, Tai DI, Lee SD, Liaw YF. Shih WL, et al. Eur J Hum Genet. 2009 Oct;17(10):1250-9. doi: 10.1038/ejhg.2009.48. Epub 2009 Apr 1. Eur J Hum Genet. 2009. PMID: 19337310 Free PMC article.
The haplotype block of the strongest association with HCC extended from the intron 5 to the 3'-flanking region of PAPSS1; multiple consecutive three-SNP haplotypes in this region were significant. ...This haplotype also revealed an association with elevated serum alpha-fet …
The haplotype block of the strongest association with HCC extended from the intron 5 to the 3'-flanking region of PAPSS1; multiple co …
Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1.
Mueller JW, Idkowiak J, Gesteira TF, Vallet C, Hardman R, van den Boom J, Dhir V, Knauer SK, Rosta E, Arlt W. Mueller JW, et al. J Biol Chem. 2018 Jun 22;293(25):9724-9735. doi: 10.1074/jbc.RA118.002248. Epub 2018 May 9. J Biol Chem. 2018. PMID: 29743239 Free PMC article.
In knockdown studies in human adrenocortical NCI-H295R1 cells, we found that PAPSS2, but not PAPSS1, is required for efficient DHEA sulfation. Specific APS kinase activity, the rate-limiting step in PAPS biosynthesis, did not differ between PAPSS1 and PAPSS2. Co-exp …
In knockdown studies in human adrenocortical NCI-H295R1 cells, we found that PAPSS2, but not PAPSS1, is required for efficient DHEA s …
45 results