Pargellis CA - Search Results

1

Inhibition of pro-inflammatory cytokine production by the dual p38/JNK2 inhibitor BIRB796 correlates with the inhibition of p38 signaling.

Gruenbaum LM, Schwartz R, Woska JR Jr, DeLeon RP, Peet GW, Warren TC, Capolino A, Mara L, Morelock MM, Shrutkowski A, Jones JW, Pargellis CA. Gruenbaum LM, et al. Among authors: pargellis ca. Biochem Pharmacol. 2009 Feb 1;77(3):422-32. doi: 10.1016/j.bcp.2008.10.032. Epub 2008 Nov 5. Biochem Pharmacol. 2009. PMID: 19027720

2

Thermal denaturation: a method to rank slow binding, high-affinity P38alpha MAP kinase inhibitors.

Kroe RR, Regan J, Proto A, Peet GW, Roy T, Landro LD, Fuschetto NG, Pargellis CA, Ingraham RH. Kroe RR, et al. Among authors: pargellis ca. J Med Chem. 2003 Oct 23;46(22):4669-75. doi: 10.1021/jm030120s. J Med Chem. 2003. PMID: 14561086

3

Catalysis and function of the p38 alpha.MK2a signaling complex.

Lukas SM, Kroe RR, Wildeson J, Peet GW, Frego L, Davidson W, Ingraham RH, Pargellis CA, Labadia ME, Werneburg BG. Lukas SM, et al. Among authors: pargellis ca. Biochemistry. 2004 Aug 10;43(31):9950-60. doi: 10.1021/bi049508v. Biochemistry. 2004. PMID: 15287722

4

Effect of deoxycoformycin and Val-boroPro on the associated catalytic activities of lymphocyte CD26 and ecto-adenosine deaminase.

Jeanfavre DD, Woska JR Jr, Pargellis CA, Kennedy CA, Prendergast J, Stearns C, Reilly PL, Barton RW, Bormann BJ. Jeanfavre DD, et al. Among authors: pargellis ca. Biochem Pharmacol. 1996 Dec 13;52(11):1757-65. doi: 10.1016/s0006-2952(96)00597-7. Biochem Pharmacol. 1996. PMID: 8986139

5

The kinetics of binding to p38MAP kinase by analogues of BIRB 796.

Regan J, Pargellis CA, Cirillo PF, Gilmore T, Hickey ER, Peet GW, Proto A, Swinamer A, Moss N. Regan J, et al. Among authors: pargellis ca. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3101-4. doi: 10.1016/s0960-894x(03)00656-5. Bioorg Med Chem Lett. 2003. PMID: 12941343

6

Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796).

Regan J, Capolino A, Cirillo PF, Gilmore T, Graham AG, Hickey E, Kroe RR, Madwed J, Moriak M, Nelson R, Pargellis CA, Swinamer A, Torcellini C, Tsang M, Moss N. Regan J, et al. Among authors: pargellis ca. J Med Chem. 2003 Oct 23;46(22):4676-86. doi: 10.1021/jm030121k. J Med Chem. 2003. PMID: 14561087

7

Time-resolved ligand exchange reactions: kinetic models for competitive inhibitors with recombinant human renin.

Morelock MM, Pargellis CA, Graham ET, Lamarre D, Jung G. Morelock MM, et al. Among authors: pargellis ca. J Med Chem. 1995 May 12;38(10):1751-61. doi: 10.1021/jm00010a019. J Med Chem. 1995. PMID: 7752198

8

Kinetic characterization of human immunodeficiency virus type 1 protease: determination of inhibitor rate constants during dynamic monomer-dimer interconversion.

Morelock MM, Graham ET, Erdman D, Pargellis CA. Morelock MM, et al. Among authors: pargellis ca. Arch Biochem Biophys. 1996 Apr 15;328(2):317-23. doi: 10.1006/abbi.1996.0179. Arch Biochem Biophys. 1996. PMID: 8645010

9

Determination of kinetic rate constants for the binding of inhibitors to HIV-1 protease and for the association and dissociation of active homodimer.

Pargellis CA, Morelock MM, Graham ET, Kinkade P, Pav S, Lubbe K, Lamarre D, Anderson PC. Pargellis CA, et al. Biochemistry. 1994 Oct 18;33(41):12527-34. doi: 10.1021/bi00207a021. Biochemistry. 1994. PMID: 7918476

10

Characterization of the binding site for nevirapine (BI-RG-587), a nonnucleoside inhibitor of human immunodeficiency virus type-1 reverse transcriptase.

Cohen KA, Hopkins J, Ingraham RH, Pargellis C, Wu JC, Palladino DE, Kinkade P, Warren TC, Rogers S, Adams J, et al. Cohen KA, et al. J Biol Chem. 1991 Aug 5;266(22):14670-4. J Biol Chem. 1991. PMID: 1713587 Free article.

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