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TNFalpha Induces LGR5+ Stem Cell Dysfunction In Patients With Crohn's Disease.
Lee C, An M, Joung JG, Park WY, Chang DK, Kim YH, Hong SN. Lee C, et al. Cell Mol Gastroenterol Hepatol. 2022;13(3):789-808. doi: 10.1016/j.jcmgh.2021.10.010. Epub 2021 Oct 23. Cell Mol Gastroenterol Hepatol. 2022. PMID: 34700029 Free PMC article.
METHODS: Human enteroids derived from patients with CD and controls were treated with TNFalpha (30 ng/mL), and cell viability and gene expression patterns were evaluated. RESULTS: TNFalpha induced MLKL-mediated necroptotic cell death, which was more pronounced in CD …
METHODS: Human enteroids derived from patients with CD and controls were treated with TNFalpha (30 ng/mL), and cell viability and gen …
Gut Epithelial Inositol Polyphosphate Multikinase Alleviates Experimental Colitis via Governing Tuft Cell Homeostasis.
Park SE, Lee D, Jeong JW, Lee SH, Park SJ, Ryu J, Oh SK, Yang H, Fang S, Kim S. Park SE, et al. Cell Mol Gastroenterol Hepatol. 2022;14(6):1235-1256. doi: 10.1016/j.jcmgh.2022.08.004. Epub 2022 Aug 19. Cell Mol Gastroenterol Hepatol. 2022. PMID: 35988719 Free PMC article.
Both bulk and single-cell RNA sequencing were performed to analyze IPMK-deficient colonic epithelial cells and colonic tuft cells. ...CONCLUSIONS: Cholinergic output from tuft cells is known to be critical for the restoration of intestinal architecture upon damage, support …
Both bulk and single-cell RNA sequencing were performed to analyze IPMK-deficient colonic epithelial cells and colonic tuft cells. .. …
Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic Hepatitis.
Li Y, Jiang JX, Fan W, Fish SR, Das S, Gupta P, Mozes G, Vancza L, Sarkar S, Kunimoto K, Chen D, Park H, Clemens D, Tomilov A, Cortopassi G, Török NJ. Li Y, et al. Cell Mol Gastroenterol Hepatol. 2023;15(1):197-211. doi: 10.1016/j.jcmgh.2022.09.005. Epub 2022 Sep 17. Cell Mol Gastroenterol Hepatol. 2023. PMID: 36122677 Free PMC article.
Lipid peroxidation, proinflammatory signals, redox radicals, reduced nicotinamide adenine dinucleotide/oxidized nicotinamide adenine dinucleotide ratio, as well as cleaved caspase 8, B-cell-receptor-associated protein 31 (BAP31), Bcl-2-associated X protein (Bax), and Bcl-2 …
Lipid peroxidation, proinflammatory signals, redox radicals, reduced nicotinamide adenine dinucleotide/oxidized nicotinamide adenine dinucle …
Histamine Signaling Is Essential for Tissue Macrophage Differentiation and Suppression of Bacterial Overgrowth in the Stomach.
Kim KH, Park J, Cho Y, Cho SY, Lee B, Jeong H, Lee Y, Yi JW, Oh Y, Lee JJ, Wang TC, Lim KM, Nam KT. Kim KH, et al. Cell Mol Gastroenterol Hepatol. 2023;15(1):213-236. doi: 10.1016/j.jcmgh.2022.09.008. Epub 2022 Sep 24. Cell Mol Gastroenterol Hepatol. 2023. PMID: 36167263 Free PMC article.
To identify stomach macrophages and find the new macrophage population, we performed single-cell RNA sequencing analysis on Hdc(+/+) and Hdc(-/-) stomach tissues. RESULTS: Single-cell RNA sequencing and flow cytometry of the stomach cells of Hdc(-/-) mice showed alt …
To identify stomach macrophages and find the new macrophage population, we performed single-cell RNA sequencing analysis on Hdc(+/+) …
TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models.
Longo M, Meroni M, Paolini E, Erconi V, Carli F, Fortunato F, Ronchi D, Piciotti R, Sabatini S, Macchi C, Alisi A, Miele L, Soardo G, Comi GP, Valenti L, Ruscica M, Fracanzani AL, Gastaldelli A, Dongiovanni P. Longo M, et al. Cell Mol Gastroenterol Hepatol. 2022;13(3):759-788. doi: 10.1016/j.jcmgh.2021.11.007. Epub 2021 Nov 23. Cell Mol Gastroenterol Hepatol. 2022. PMID: 34823063 Free PMC article.