Parker EJ - Search Results

1

Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis.

Cross PJ, Dobson RC, Patchett ML, Parker EJ. Cross PJ, et al. Among authors: parker ej. J Biol Chem. 2011 Mar 25;286(12):10216-24. doi: 10.1074/jbc.M110.209924. Epub 2011 Jan 30. J Biol Chem. 2011. PMID: 21282100 Free PMC article.

2

Substrate deactivation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase by erythrose 4-phosphate.

Parker EJ, Bulloch EM, Jameson GB, Abell C. Parker EJ, et al. Biochemistry. 2001 Dec 11;40(49):14821-8. doi: 10.1021/bi010928j. Biochemistry. 2001. PMID: 11732901

3

Expression, purification, and characterization of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Pyrococcus furiosus.

Schofield LR, Patchett ML, Parker EJ. Schofield LR, et al. Among authors: parker ej. Protein Expr Purif. 2004 Mar;34(1):17-27. doi: 10.1016/j.pep.2003.11.008. Protein Expr Purif. 2004. PMID: 14766297

4

Stereospecific deuteration of 2-deoxyerythrose 4-phosphate using 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase.

Williamson RM, Pietersma AL, Jameson GB, Parker EJ. Williamson RM, et al. Among authors: parker ej. Bioorg Med Chem Lett. 2005 May 2;15(9):2339-42. doi: 10.1016/j.bmcl.2005.02.080. Bioorg Med Chem Lett. 2005. PMID: 15837321

5

Characterization of a recombinant type II 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Helicobacter pylori.

Webby CJ, Patchett ML, Parker EJ. Webby CJ, et al. Among authors: parker ej. Biochem J. 2005 Aug 15;390(Pt 1):223-30. doi: 10.1042/BJ20050259. Biochem J. 2005. PMID: 15853768 Free PMC article.

6

Substrate ambiguity and crystal structure of Pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase: an ancestral 3-deoxyald-2-ulosonate-phosphate synthase?

Schofield LR, Anderson BF, Patchett ML, Norris GE, Jameson GB, Parker EJ. Schofield LR, et al. Among authors: parker ej. Biochemistry. 2005 Sep 13;44(36):11950-62. doi: 10.1021/bi050577z. Biochemistry. 2005. PMID: 16142893

7

Mechanistic divergence of two closely related aldol-like enzyme-catalysed reactions.

Ahn M, Pietersma AL, Schofield LR, Parker EJ. Ahn M, et al. Among authors: parker ej. Org Biomol Chem. 2005 Nov 21;3(22):4046-9. doi: 10.1039/b511661a. Epub 2005 Oct 6. Org Biomol Chem. 2005. PMID: 16267580

8

The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes.

Webby CJ, Baker HM, Lott JS, Baker EN, Parker EJ. Webby CJ, et al. Among authors: parker ej. J Mol Biol. 2005 Dec 9;354(4):927-39. doi: 10.1016/j.jmb.2005.09.093. Epub 2005 Oct 21. J Mol Biol. 2005. PMID: 16288916

9

Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis.

Webby CJ, Lott JS, Baker HM, Baker EN, Parker EJ. Webby CJ, et al. Among authors: parker ej. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Apr 1;61(Pt 4):403-6. doi: 10.1107/S1744309105007931. Epub 2005 Mar 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID: 16511053 Free PMC article.

10

Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-D-arabino heptulosonate 7-phosphate synthase.

Walker SR, Parker EJ. Walker SR, et al. Among authors: parker ej. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2951-4. doi: 10.1016/j.bmcl.2006.02.073. Epub 2006 Mar 24. Bioorg Med Chem Lett. 2006. PMID: 16563755

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