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HIV-1 drug resistance in newly infected individuals.
Boden D, Hurley A, Zhang L, Cao Y, Guo Y, Jones E, Tsay J, Ip J, Farthing C, Limoli K, Parkin N, Markowitz M. Boden D, et al. Among authors: parkin n. JAMA. 1999 Sep 22-29;282(12):1135-41. doi: 10.1001/jama.282.12.1135. JAMA. 1999. PMID: 10501116
Changes in human immunodeficiency virus type 1 Gag at positions L449 and P453 are linked to I50V protease mutants in vivo and cause reduction of sensitivity to amprenavir and improved viral fitness in vitro.
Maguire MF, Guinea R, Griffin P, Macmanus S, Elston RC, Wolfram J, Richards N, Hanlon MH, Porter DJ, Wrin T, Parkin N, Tisdale M, Furfine E, Petropoulos C, Snowden BW, Kleim JP. Maguire MF, et al. Among authors: parkin n. J Virol. 2002 Aug;76(15):7398-406. doi: 10.1128/jvi.76.15.7398-7406.2002. J Virol. 2002. PMID: 12097552 Free PMC article.
A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1.
Petropoulos CJ, Parkin NT, Limoli KL, Lie YS, Wrin T, Huang W, Tian H, Smith D, Winslow GA, Capon DJ, Whitcomb JM. Petropoulos CJ, et al. Among authors: parkin nt. Antimicrob Agents Chemother. 2000 Apr;44(4):920-8. doi: 10.1128/AAC.44.4.920-928.2000. Antimicrob Agents Chemother. 2000. PMID: 10722492 Free PMC article.
Nelfinavir-resistant, amprenavir-hypersusceptible strains of human immunodeficiency virus type 1 carrying an N88S mutation in protease have reduced infectivity, reduced replication capacity, and reduced fitness and process the Gag polyprotein precursor aberrantly.
Resch W, Ziermann R, Parkin N, Gamarnik A, Swanstrom R. Resch W, et al. Among authors: parkin n. J Virol. 2002 Sep;76(17):8659-66. doi: 10.1128/jvi.76.17.8659-8666.2002. J Virol. 2002. PMID: 12163585 Free PMC article.
Relative fitness and replication capacity of a multinucleoside analogue-resistant clinical human immunodeficiency virus type 1 isolate with a deletion of codon 69 in the reverse transcriptase coding region.
Villena C, Prado JG, Puertas MC, Martínez MA, Clotet B, Ruiz L, Parkin NT, Menéndez-Arias L, Martinez-Picado J. Villena C, et al. J Virol. 2007 May;81(9):4713-21. doi: 10.1128/JVI.02135-06. Epub 2007 Feb 21. J Virol. 2007. PMID: 17314158 Free PMC article.
160 results